Protein Alignment FBXW10 and Fbxw10

DIOPT Version :10

• Sequence 1: XP_047291077.1
• Gene: FBXW10 / 10517
• HGNCID: 1211
• Length: 1103
• Species: Homo sapiens
• Sequence 2: NP_001278370.1
• Gene: Fbxw10 / 213980
• MGIID: 3052463
• Length: 1025
• Species: Mus musculus
• Alignment Length: 1115
• Identity: 733/1115 - (65%)
• Similarity: 853/1115 - (76%)
• Gaps: 102/1115 - (9%)

Human     1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGILKQLN 65
            |||.|.:||.|||||||||.:.:|:|:|||.||||||||:|||||.|:||||||||||.||.|||
Mouse     1 MENREPKLKQAPYFRCEKGPNWVPVCQKCEACVLAWKIFATKEWFRRVNDISQRRFLVSILGQLN 65

Human    66 SLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGK---VVKSSLNQMLDKTVEQKMKEILYWFAN 127
            |||||.||||||:||||||||||||||.||:|.||   |||||||||||||||:|||||||||.|
Mouse    66 SLYLLQYFQNILETTQGKDFIYNRSRIKLSRKGGKEEEVVKSSLNQMLDKTVERKMKEILYWFGN 130

Human   128 STQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGKQGHRQRLEGPRRPEGKASEIWL 192
            ||..|||||||||||||:..|||||||||||||::|.|:|||                      |
Mouse   131 STHRTKANYTLLLLQMCDSNLLLTAANVIRVLFMKEWNSISG----------------------L 173

Human   193 NQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAAS----NPEEPWRNSL 253
            :.|..||.|.|||.:|....||.|.|.|:.:..|.|:||...|:  ||..:    ..|....:||
Mouse   174 HDDTPDVMFFPEKKYSGTQDTSYVSWAARPKPVSFPMSKHLGNK--LGTENVDRETTEGKGESSL 236

Human   254 RCISEMNRLFSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILSMLGCM 318
            :||.||||...|||.:::.|.||||||:.||.::.||||:||||||||.||:|||||||.
Mouse   237 QCIHEMNRQIFGKGGMSRLGDDPCNLLLSLDHVQLLSSGYSKYRDFIRDLPLHLSKYILR----- 296

Human   319 RGFPRHLPSWPSSGVSGSIFFFPGMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFL 383
                                    |||:|:||:|..||||||.:|||||:|.|.|.||||||:.|
Mouse   297 ------------------------MLDKHSLNRCIFVSQHWATLAQQVKVDQSMHSFIQNQISLL 337

Human   384 QGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERN 448
            ||||||||||||||||||||||:|||||..|.|:.|||||||.:||||.||||:|||.|.:||||
Mouse   338 QGSYTRGIDPNYANKVSIPVPKIVDDGKRSRSKNQKWKLRTKTDYNLWNAYQNQETQLVQMEERN 402

Human   449 VFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLC 513
            |||||||:|:||||:||||:|||:||||:|:|||||||||||:|.|.:|:||||||||||||||.
Mouse   403 VFCGTYNIRVLSDTFDQNRIIHYNGGDLMAISSNRKIHLLDIMQTKELPIEFRGHAGSVRALFLS 467

Human   514 EEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKC 578
            ||:|.||||||||||||||:|:|.|.|||.||||||||:|:.|||||||.:|.|||.||::||||
Mouse   468 EEDNILLSGSYDLSIRYWDVKTGACVRIFYGHQGTITCLDVYKNRLVSGAKDGQVKEWDIETGKC 532

Human   579 LKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGST 643
            ||||:|||||||.:|::||||||||||:|||||:..|||.|||:|||||||||||::|||:||..
Mouse   533 LKTFKHKDPILAAKISETYIVSSCERGIVKVWHVVTAQLQKTLTGHEGAVKCLFFNEWHLVSGGA 597

Human   644 DGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRG 708
            |||||||||||||||||||||||||||.||||:|||||||.||||||||||||||:||:|.:.||
Mouse   598 DGLVMAWSMVGKYERCLMAFKHPKEVLQVSLLYLRVISACGDGKIRIYNFLNGNCLKVIKVDARG 662

Human   709 DPVLSFFIQGN-----RMVVNTESNVLMFQFEHIKWQYAVEKTKQKKNKEKEEEKEENSLMEILS 768
            |||||||.|||     |||.:|:||:|:||||::||||:.:|.|.||:|:||||:||.||.:..|
Mouse   663 DPVLSFFYQGNRWVVGRMVAHTDSNILVFQFENVKWQYSSDKNKVKKSKDKEEEREETSLGDEHS 727

Human   769 KCNIQVHSPRESVSSKQTVIQELLPGKPPKSRVLLKPAKFSSAVLIEELQSQGKSKSPRRDADDV 833
            :..||.||.::||||||..         .||||.||..|..|                   :||
Mouse   728 RSTIQGHSLKDSVSSKQEF---------SKSRVHLKQTKNLS-------------------SDD- 763

Human   834 EKAQKQGQLETPGKLPSHPKKKSWKIPMSPDQFLLTVSALQHAHNSGEFAYPCRPQTEITDVWGP 898
                    :|||....|||.:|.||:||:||:||||:||||.||||.|||||.||:.::.|.|||
Mouse   764 --------METPVGEVSHPLQKLWKVPMTPDRFLLTISALQQAHNSEEFAYPHRPRPQVIDAWGP 820

Human   899 SISYPRKVLNFKGKSIQRAVDRLRLSNPPIDVKRTSIPLEIQKLQPNLKISLHSPRVQSTIPQPM 963
            ||.||||||:.||||:|.|||:||.||.|..|::|:|||||||||||||.||||||||:|:|||.
Mouse   821 SIPYPRKVLSLKGKSVQHAVDQLRSSNLPTGVRQTNIPLEIQKLQPNLKKSLHSPRVQATVPQPS 885

Human   964 IIRSRFSGSLKGGDQVTSSIERAVCSTGPLTSMQVIKPNRMLAPQVGTATLSLKKERPRIYTALD 1028
            :||.:.|.||:|.:.:||||:..:...|||||||||||||||||:.||||||.||||||.||.||
Mouse   886 LIRPKVSDSLRGDEHLTSSIDGTMRRAGPLTSMQVIKPNRMLAPRGGTATLSPKKERPRFYTTLD 950

Human  1029 PFRVNTEFVLLTVKEEKEHQEAKMKEYQARESTGVVDPGKVSKAAWIRKIKGLPIDNFTKQGKTA 1093
            |.|:||.|:|:|||||||..|||||||:|..||..|||||.|||||||||||||||||.|:||||
Mouse   951 PLRMNTGFMLMTVKEEKEFAEAKMKEYEASVSTKEVDPGKASKAAWIRKIKGLPIDNFMKEGKTA 1015

Human  1094 APELGQNVFI 1103
            ||||||||||
Mouse  1016 APELGQNVFI 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXW10	XP_047291077.1	F-box_SF	299..367	CDD:459239	28/67 (42%)
		WD40	469..704	CDD:238121	188/234 (80%)
		WD40 repeat	508..544	CDD:293791	28/35 (80%)
		WD40 repeat	549..583	CDD:293791	24/33 (73%)
		WD40 repeat	589..622	CDD:293791	23/32 (72%)
		WD40 repeat	628..664	CDD:293791	30/35 (86%)
		WD40 repeat	672..703	CDD:293791	27/30 (90%)
Fbxw10	NP_001278370.1	F-box_FBXW10	282..321	CDD:438908	28/67 (42%)
		WD40	423..657	CDD:238121	188/233 (81%)
		WD 1	456..495		31/38 (82%)
		WD40 repeat	462..498	CDD:293791	28/35 (80%)
		WD 2	498..537		29/38 (76%)
		WD40 repeat	503..536	CDD:293791	23/32 (72%)
		WD 3	539..574		25/34 (74%)
		WD40 repeat	543..576	CDD:293791	23/32 (72%)
		WD 4	577..614		31/36 (86%)
		WD40 repeat	582..618	CDD:293791	30/35 (86%)
		WD 5	616..657		36/40 (90%)
		WD40 repeat	623..657	CDD:293791	29/33 (88%)
		WD40 repeat	665..691	CDD:293791	15/25 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..768		36/100 (36%)