DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBLN5 and fbln5

DIOPT Version :9

Sequence 1:	NP_001371087.1	Gene:	FBLN5 / 10516	HGNCID:	3602	Length:	489	Species:	Homo sapiens
Sequence 2:	NP_001025619.1	Gene:	fbln5 / 595007	XenbaseID:	XB-GENE-983056	Length:	439	Species:	Xenopus tropicalis

Alignment Length:	484	Identity:	330/484 - (68%)
Similarity:	391/484 - (80%)	Gaps:	49/484 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     6 RILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDGVSLSSPRLECNGAISAHCNLCLPGSSD 70
            ||||:..|.||:....:||.||||||::||.:||||
Frog     5 RILTLITLCLCITDSVHAQQQCTNGFEMDRSTGQCL----------------------------- 40

Human    71 SSASASQVAGITDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPA 135
                        |:||||.|.:||||||||||||||||||||||.::|..:.||:       .||
Frog    41 ------------DVDECRIILDACRGDMMCVNQNGGYLCIPRTNTMFRPSFRNPF-------LPA 86

Human   136 AAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGY 200
            ||.||..||:|:..||||||||||:|| :||||:||||:::|||||||||||||||||||||:||
Frog    87 AAAPLPPPNFPSPPRPLICRFGYQIDE-DQCVDIDECASETHQCNPTQICINTEGGYTCSCTEGY 150

Human   201 WLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNT 265
            |||||||||||||||||||||||||||||||||||||.||.||||||||:||.|:|||||||:||
Frog   151 WLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFILNTDGRSCQDVDECITDNPCVQTCMNT 215

Human   266 YGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDI 330
            |||::|||:.||||:||||:||||||||.|||||||:|||:||:|:|.||.||:||||:|:||||
Frog   216 YGSYLCRCEAGYELDEDGVNCSDMDECSVSEFLCQHDCVNEPGSYYCRCPEGYVLLDDSRTCQDI 280

Human   331 NECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMD 395
            :||:..|:||.|||.|:|:.|.::|:|.:|||:||::|:|||||||.||..||||||||::|.||
Frog   281 DECDTGNNTCTLQQLCFNIPGSYRCLDTVRCEDPYIQINDNRCMCPVENTACRDQPFTIVHRHMD 345

Human   396 VVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLD 460
            ::|.||||.||||||||||:|||||||||||||||||||||||||||||||:||||.|||::.||
Frog   346 LLSTRSVPTDIFQMQATTRFPGAYYIFQIKSGNEGREFYMRQTGPISATLVLTRPITGPRDLVLD 410

Human   461 LEMITVNTVINFRGSSVIRLRIYVSQYPF 489
            |||:|||||::|||||||||||:||||.|
Frog   411 LEMVTVNTVVSFRGSSVIRLRIFVSQYLF 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBLN5	NP_001371087.1	EGF_CA	168..>201	CDD:311536	27/32 (84%)
		vWFA	<202..245	CDD:412136	40/42 (95%)
		cEGF	228..251	CDD:403760	20/22 (91%)
		EGF_CA	248..286	CDD:214542	28/37 (76%)
		FXa_inhibition	299..327	CDD:405372	19/27 (70%)
fbln5	NP_001025619.1	vWFA	<103..156	CDD:381780	45/53 (85%)
		cEGF	178..201	CDD:372248	20/22 (91%)
		EGF_CA	198..236	CDD:214542	28/37 (76%)
		vWFA	<236..276	CDD:381780	30/39 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I11162
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38170
Inparanoid	1	1.050	752	1.000	Inparanoid score	I4889
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43097
OrthoDB	1	1.010	-	-		D132288at32523
OrthoFinder	1	1.000	-	-		FOG0001864
OrthoInspector	1	1.000	-	-		oto151100
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6974
SonicParanoid	1	1.000	-	-		X8595
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010