DRSC/TRiP Functional Genomics Resources

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Protein Alignment APPBP2 and Klc

DIOPT Version :9

Sequence 1:NP_006371.2 Gene:APPBP2 / 10513 HGNCID:622 Length:585 Species:Homo sapiens
Sequence 2:NP_001261780.1 Gene:Klc / 39445 FlyBaseID:FBgn0010235 Length:508 Species:Drosophila melanogaster


Alignment Length:217 Identity:57/217 - (26%)
Similarity:102/217 - (47%) Gaps:17/217 - (7%)


- Green bases have known domain annotations that are detailed below.


Human   342 VHQYSS-GKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQE 405
            |.||:| |:::.|:...::|:..:......||..:|:...:.||:..           :|...:|
  Fly   193 VIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYR-----------DQNKYKE 246

Human   406 AHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEV 470
            |.:|...:|.:..|..||.:...|....||..||....|:|:||.:..:|::|:|::||::..:|
  Fly   247 AANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDV 311

Human   471 ALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNY-EKVF 534
            |..:.:||.|.. :..:|:..||.|.|::.|.:...|.....:......|...|...|.| |...
  Fly   312 AKQLNNLALLCQ-NQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEI 375

Human   535 EYHNVLSNWNRLRDRQYSVTDA 556
            .|..||:   |..:|::...|:
  Fly   376 LYKQVLT---RAHEREFGAIDS 394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APPBP2NP_006371.2 TPR 1 50..83
TPR 2 120..153
TPR 3 206..239
TPR_12 284..363 CDD:290160 7/21 (33%)
TPR 4 288..321
TPR 5 333..367 7/25 (28%)
TPR_12 427..504 CDD:290160 25/76 (33%)
TPR_10 428..466 CDD:290111 14/37 (38%)
TPR 6 429..462 12/32 (38%)
TPR repeat 429..457 CDD:276809 10/27 (37%)
TPR repeat 470..501 CDD:276809 10/30 (33%)
TPR 7 471..505 10/33 (30%)
TPR 8 514..547 9/33 (27%)
KlcNP_001261780.1 TPR_12 185..258 CDD:315987 17/75 (23%)
TPR repeat 187..214 CDD:276809 7/20 (35%)
TPR_12 226..302 CDD:315987 22/86 (26%)
TPR repeat 228..256 CDD:276809 7/38 (18%)
TPR_12 269..344 CDD:315987 25/75 (33%)
TPR repeat 270..298 CDD:276809 10/27 (37%)
TPR_12 310..384 CDD:315987 20/77 (26%)
TPR repeat 311..341 CDD:276809 10/30 (33%)
TPR_12 353..469 CDD:315987 11/45 (24%)
TPR repeat 354..381 CDD:276809 6/26 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1840
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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