DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SEMA4B and Sema1a

DIOPT Version :9

Sequence 1:	NP_001310963.1	Gene:	SEMA4B / 10509	HGNCID:	10730	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	867	Identity:	249/867 - (28%)
Similarity:	382/867 - (44%)	Gaps:	197/867 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    27 LLLLLLLLLQPPPPTWA--LSPRISLPLGSEERPFLRFEAEHISNYTAL----LLSRDGRTLYVG 85
            :.|||.:|:......|.  :.|::.:.||.|:  .|:|    :.|.:.:    |:::||.:|.:|
  Fly    52 VFLLLTVLVIGNQSAWQENIRPKLYVELGPED--VLKF----VGNESVVDHFKLVTKDGNSLLIG 110

Human    86 AREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCG 150
            ||..:|    |||.....|.|.|:|.:..:..:.|..|||| :..|||||:|::..|...||.||
  Fly   111 ARNTVF----NLSIHDLVEQQRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPGRLFVCG 170

Human   151 TAAFSPMC-TY-INMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGN 213
            |.:|.||| || |:..|:||...:.|..:       ||:||...||:::.|.|||:|||:.|.|:
  Fly   171 TNSFRPMCNTYIISDSNYTLEATKNGQAV-------CPYDPRHNSTSVLADNELYSGTVADFSGS 228

Human   214 DPAISRSQSLRPTKTE--SSLNWLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFEN 276
            ||.|.|    .|.:||  .||: |..|.||:|        ..||  |.:||||.||..||.....
  Fly   229 DPIIYR----EPLQTEQYDSLS-LNAPNFVSS--------FTQG--DFVYFFFRETAVEFINCGK 278

Human   277 TIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDD-GFPFNVLQDVFTLSPSPQ-DWRDTL 339
            .|.||:||:||.|:||....:.|||||||::|.||.|.| .|.||.:|....|..... .....|
  Fly   279 AIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKL 343

Human   340 FYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNS 403
            .||||.:.  ..:..|||||.|.::|:...|.|.:||.......|..|.: .||.||||:|
  Fly   344 IYGVFNTP--SNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC---- 402

Human   404 ARERKINSSLQLPDRVLNFLKDHFLMDGQVR---SRMLLLQPQA--RYQRVAVH---RVPGLHHT 460
                 .|.|..|||..|||:|.|.|||..|.   |:.:|::...  |:.::||.   :.|| ..|
  Fly   403 -----HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPG-GKT 461

Human   461 YDVLFLGTGDGRLHKAVSV-----GPRVH--IIEELQIFSSGQPVQNL-LLDTHRVSRPTRNP-G 516
            |||:|:||..|::.|:|:.     ..:|.  :|||:.:.:..:|::|| ::.|.:..:|.... .
  Fly   462 YDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYD 526

Human   517 RGLLYAASHSGVVQVPMANC--SLYRSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDI 579
            .|.|...:.|.||.:.:..|  ....||.:|:..:||||||...:.|..|...|:     |::
  Fly   527 DGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPR-----WLE-- 584

Human   580 EGASAKDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASAS 644
            |....:::.:......||                ..:|:..    :|...:...||
  Fly   585 ENYFYQNVATGQHAACPS----------------GKINSKD----ANAGEQKGFRN--------- 620

Human   645 CHVLPTGDLLLVGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVS 709
                   |:.|:.:::..:.|                 |::::  .|:..||..    ||...::
  Fly   621 -------DMDLLDSRRQSKDQ-----------------EIIDN--IDKNFEGPQ----ISADIIN 655

Human   710 APAGGKASWGADRSYWKEFLVMCTL--FVLAVLLPVLFLLYRHRNSMK-------------VFLK 759
            |            .|..|.|||..|  .:.::|:......:..|...|             .:.:
  Fly   656 A------------QYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFE 708

Human   760 QGECASVHPKTC-------------------PVVLPPETRPLNGLGPPST---PLDHRGYQSLSD 802
            |.:..:..|.:|                   ||:||....|.....|.:|   |..|:.:|.
  Fly   709 QRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQG--- 770

Human   803 SPPGSRVFTESEKRPLSIQDSF 824
              |.|....:.:....:.|.|:
  Fly   771 --PNSETLFQFQPDGYNTQQSY 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SEMA4B	NP_001310963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..815		8/40 (20%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	180/493 (37%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/33 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910