DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SEMA6C and Sema1a

DIOPT Version :9

Sequence 1:	NP_001171532.1	Gene:	SEMA6C / 10500	HGNCID:	10740	Length:	962	Species:	Homo sapiens
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	1117	Identity:	314/1117 - (28%)
Similarity:	448/1117 - (40%)	Gaps:	286/1117 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     7 FMPLLLLLLLLSLPHTQAAFPQDPLPLLISDLQGTSPLSWFRGLED--DAVAAELGLDFQRFLTL 69
            :|.:.|||.:|.:.: |:|:.::..|.|..:|          |.||  ..|..|..:|..:.:|.
  Fly    49 WMQVFLLLTVLVIGN-QSAWQENIRPKLYVEL----------GPEDVLKFVGNESVVDHFKLVTK 102

Human    70 N-RTLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRS--QDVENCAVRGKLTDECYNYIRVLVPW 131
            : .:||:.||:.||:..:      ..||..:.|.|.|  .|.:.|.|:||..:.|.||||::|..
  Fly   103 DGNSLLIGARNTVFNLSI------HDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVP 161

Human   132 DSQTLLACGTNSFSPVCRSYGITSLQQEGEEL-SGQARCPFDATQSNVAIFAEGSLYSATAADFQ 195
            ....|..||||||.|:|.:|.|:......|.. :|||.||:|...::.::.|:..|||.|.|||.
  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFS 226

Human   196 ASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALEHGDHVYFFFREVSVEDARLGRVQFSRVAR 260
            .||.::||.     ||::.:|||..|..|:||.:...||.|||||||.:||....|:..:|||||
  Fly   227 GSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVAR 286

Human   261 VCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQA----LTGPVNLHGRSALFGVFTT 321
            |||.|.|| |......||||||.|||||:|||..|||:.:|:    :.|.........::|||.|
  Fly   287 VCKWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNT 350

Human   322 QTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGAALFSSSR 386
            .:|||||||||||.|.:|...|||:||||..::..|.||:..:||.||||||        .:.||
  Fly   351 PSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------HNDSR 407

Human   387 DLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRAL-LTQVAVDGMAGPHSNIT--VMFLGSNDG 448
            .|||..|.|||.|.|:|..||....||:|..||... .||:|||.........|  |:|:|::.|
  Fly   408 ALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHG 472

Human   449 TVLKVLTPGGRSGGPE--PILLEEIDAYS---PAR-CSGKRTAQTARRIIGLELDTEGHRLFVAF 507
            .::|.:.........:  .:::||||..:   |.| ....||.|..:...|   ..:..:|.:..
  Fly   473 KIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDG---SYDDGKLIIVT 534

Human   508 SGCIVYLPLSRCARHG----ACQRSCLASQDPYCGWHSSRG-CVDIRGSGGTDVDQAG----NQE 563
            ...:|.:.|.||  |.    :|. .|:|.|||||.|....| |   |..|.....:..    |..
  Fly   535 DSQVVAIQLHRC--HNDKITSCS-ECVALQDPYCAWDKIAGKC---RSHGAPRWLEENYFYQNVA 593

Human   564 SMEHGDCQDGATGSQSGPGDSAYVLPGPGPSPGTPSPPSDAHPRPQSSTLGVHTRGVRRDLPPAS 628
            :.:|..|..|...|:                        ||:...|        :|.|.|:....
  Fly   594 TGQHAACPSGKINSK------------------------DANAGEQ--------KGFRNDMDLLD 626

Human   629 ASRSVPIPLLLASVAAAF----------------------ALGASVSGLLVS------CACRRAH 665
            :.|......::.::...|                      .|..|:..|||.      |. ||.|
  Fly   627 SRRQSKDQEIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCG-RRCH 690

Human   666 RRRGKDIETPGLPRP-------------LSLRSLARLHGGG-----------------PEPPPPS 700
                || |...||.|             .|..|..|:....                 |:||||:
  Fly   691 ----KD-EDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPN 750

Human   701 KDGDAVQTPQLYTTFLPPP-----EGVPPPELACL----PTPESTPEL--------PVKHLRAAG 748
            |    :.:|:  .|...||     :|   |....|    |...:|.:.        .::..:..|
  Fly   751 K----MHSPK--NTLRKPPMHQMHQG---PNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMG 806

Human   749 DPWEWN-------------QNRNNAKEGPGRSR---------GGHAAGGPAPRVLVRPPPPGCPG 791
            |.:...             .|.|......||:|         ..|.:..|..:......|....|
  Fly   807 DNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSSG 871

Human   792 QAVEVTTLEELLRYLHGPQPPRKGAEPPAPLTS----------------RALPPEPAPALLGGPS 840
            .:..::....      .|.||   :..|:|..|                :::|...|.:....|.
  Fly   872 SSPVMSNSSS------SPAPP---SSSPSPQESPKNCSYIYRDXLICNTKSMPLIQAQSTHAQPH 927

Human   841 PRPHECASPLRLDVPPEGRCASAPARPALSAPAPRLGVGGGRRLPFSGHRAPPALLTRVPSGG-P 904
            |:.|  ..||    ||.|. .:.||:|  .|.:|.:|....:.:|.:..: |.:.|...||.. .
  Fly   928 PQSH--PHPL----PPPGP-TTPPAQP--RARSPMIGRTYAKSMPVTPVQ-PQSPLAETPSYELY 982

Human   905 SRYSGGPGKH-------------------LLYLGRPEGYRGRALKRVDVEKPQLSLKPPLVGPSS 950
            .|:|.....|                   |..:..|..|          :.|.|...|||..|.
  Fly   983 ERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPPY----------DTPHLIASPPLPPPR- 1036

Human   951 RQAVPNGGRFNF 962
                    ||.|
  Fly  1037 --------RFRF 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SEMA6C	NP_001171532.1	Sema	53..517	CDD:301699	185/480 (39%)
SEMA6C	NP_001171532.1	PSI	518..570	CDD:279745	18/60 (30%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	185/477 (39%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	15/39 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1252
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2116
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8465
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.820