Protein Alignment UNC13B and YOR296W

DIOPT Version :10

• Sequence 1: NP_001358118.1
• Gene: UNC13B / 10497
• HGNCID: 12566
• Length: 4340
• Species: Homo sapiens
• Sequence 2: NP_014939.1
• Gene: YOR296W / 854471
• SGDID: S000005822
• Length: 1289
• Species: Saccharomyces cerevisiae
• Alignment Length: 1447
• Identity: 255/1447 - (17%)
• Similarity: 453/1447 - (31%)
• Gaps: 531/1447 - (36%)

Human   606 DNVNIDRHRKTSENEHMGNKTGSLYFQNTTESIAKDLAPQSQSSVIKSVFSRLNPLKIFSEKEET 670
            |.:|..|.:   |...:.|:||       |..:..|.....|:.              ..:|...
Yeast    46 DYINEPRFK---EAALLSNRTG-------TSRVLSDKTNHQQTQ--------------HGKKLVV 86

Human   671 KKDDDQSKPPRKESFVECGLELNKRE-------------------------GTLDNYSSSIIALN 710
            .|.||.|    :...|:..|.:.|.:                         ..||:.|:...:..
Yeast    87 DKQDDMS----ERDIVQATLRILKGKLAQISGNKNLAPNEMHWKSIVKMYYSMLDSSSADTFSKM 147

Human   711 GSDEETTGWFQMPTSENLLSSQVTSEPSNLVSSASKNDESLLEEKLCIDL--SLLPDQQKICAK- 772
            |..||..|:|     .|:.|:::..     ::..:..||...|....|||  .:|||.   ||.
Yeast   148 GQMEEVVGYF-----TNIASNELKK-----MTIKNSRDELFSEVAYFIDLVIDVLPDS---CANI 199

Human   773 ---------------------------DTPGHPCIAGSRTANKE------------VFSKPLEED 798
                                       ..|.:..|:||..:||:            .|.:..|.|
Yeast   200 IKRLLDYKINLKKGETTVKKKRAASPATVPQYRSISGSTISNKQPSFKVQDISHMKYFMQLFETD 264

Human   799 KVTGNDDFLEPLRKSFSQFLLTSPETCSKESLSEPVKIRQVEEDGLERGSKKD-----GHSFSFS 858
            :...:.|.:                 ..|:..:.|:...::..  |.:..|||     ...||..
Yeast   265 ETKLHQDVM-----------------AVKDDCTNPIFCGELRY--LRKKIKKDNGTLTASDFSSD 310

Human   859 GKLNLPFFRSLGHSEKQQELKEKGSIFPLFKFSFTDSKVTVNDQSLRGSAVTTDEES-------- 915
            .:.||         .|..||.|..::...|:..   .|||.:...|    :..|.:|
Yeast   311 REYNL---------WKNYELLEIANLMDRFEIG---EKVTSHGNRL----IPKDAKSVFVRLIGL 359

Human   916 --KKNC-----------------HEDTKH------SSIKS--SSVPNIHSDLGKFDSTEEFKKND 953
              ||.|                 |:..::      |:|.|  .|..|: |.||          ::
Yeast   360 VLKKECSNAVNAINLSQEALFFFHKSARYWRIEYPSTISSLVYSAANL-SVLG----------DE 413

Human   954 QINCPEDAKLNSIKSSSVPNIHDDLEK---------FDSIKEFNKNDQVNCPEDAKLSSIKSGSA 1009
            ::|.|....|.|:..:......|:|:.         ..:...|:..||.....:..|::|.||:.
Yeast   414 ELNIPITENLFSVIRNKYLCSEDNLDPSAWNAQDRYLWAANLFHTTDQSMRTINNLLTAIFSGTK 478

Human  1010 PNTQDNLGKFDSTEEFNQNDQINSP-----EDAKFNIIK--------------SDSVTNINNDLG 1055
            |       ||.....|..::.:..|     |.....:.|              .|...::..|:.
Yeast   479 P-------KFSPVLSFYYSNIVGDPVMEFYETQSVAVKKYWIKLFKKTLFKASEDYFVSLLQDML 536

Human  1056 KFGNIEELNPSDHTAGQNFERDGLAIPGVVPKEHITSDPLGEDKNLIQAAS----SVASDSSLEC 1116
            |...||..|.      ||.....:.....:.|.:  :.||.::.:|.:..:    .|....||..
Yeast   537 KANAIEIQNV------QNLVETIIEAIKAIQKRY--NKPLLDEISLPRQCAVFLCEVYGSDSLNL 593

Human  1117 ISTTSKSTLVNEINEDEVIDKTSKKNTQGSFLSGLFNRFSSAENLSSQELNLKNDDSHHKNNTPG 1181
            |.|..|||:                                  .::.|:|              |
Yeast   594 IKTAEKSTM----------------------------------KMTGQKL--------------G 610

Human  1182 LISGI--FNLLSNSGMI--DHKPEEAKFMSLGN-----MKSLNGDNHLSLDEVPATSCVTSEN-- 1235
            .|..:  :::|.....|  ..||:...|.:|.|     :..|..|...::.:| ..|.:.|||
Yeast   611 PIDALDMYDVLKELRQIYLQVKPKGKFFFNLENYFIKYLTRLCDDVSRNVQKV-IKSSLESENWQ 674

Human  1236 PKNHVEKHETSSFIEASLLPKENIPLSDAGDDNHYCSPTEK-NQQSEKHHPSSENIVLHCAPSAQ 1299
            |.|. :.|.:.|.::...:..|:            .|..|| ..|:|........::|.......
Yeast   675 PVND-QDHFSRSVLDIFKMINES------------TSMLEKFGWQNEFQLAQMITVILKAFSDGM 726

Human  1300 LGF-------LEKSMAKRQMPNHVLEAKLHENSNKLNSPVLNTNILN-KSNNYQAFEEMNSPFCF 1356
            |.:       :::.:.:...|::.||:....:|..||    |.|:.: ||.:.:.||
Yeast   727 LSYSAQLMELIQRDLQEGDEPSYSLESSDTRSSLSLN----NANVNHEKSRSSRLFE-------- 779

Human  1357 EWDSDIKDLSKNSRKL-QPVYYMLNQNRFLSADACLWLDSENSVINFCQKDQNANILEWRTNPNS 1420
                |:|::.|::.|: .|..|...:.      .|:.|:..:..:...:.      .|.:.:|:.
Yeast   780 ----DLKNVVKSTPKMVAPAPYQFKKR------TCVLLNDLDKTLFLLES------FEEKADPSK 828

Human  1421 VIWCDLPYESFNQLAFN----------EDYLLRGDVWAANSLYGNSGPLPINEANNSLEELPIDL 1475
            :......|.|.:.|..|          :.|.||  :..|.::.|.|        ...|....:.:
Yeast   829 ISSVIAQYHSSHNLEDNGKSFDDQNMKQVYTLR--IIGAENIKGFS--------KTGLSNTYVSM 883

Human  1476 SSSSDHEK--TTCPVVDQESLRMDENFVFSS-FGYEYQEWLSCLEHGVWWPSEDGDYGYYMFHDG 1537
            .:.:...:  ||..|....:.:.||.|||.| ||                  :..|..:.::|.
Yeast   884 RNITLQREIGTTKIVARSITPKWDEEFVFESPFG------------------KSNDIMFTIWHH- 929

Human  1538 QYIYSLLTDSTGQYAYLFIPDSYQEYLDCDLQTNGLSSITLDDSIISACSFKVLDK--EDEIFWY 1600
                               |.|..:.|             .:|.:....:.|...:  :|:.|
Yeast   930 -------------------PHSRLKNL-------------AEDDLCGKANMKFTPRKLKDDGF-- 960

Human  1601 VEEEPIDDPLDLSLALPRSEEPLYLNLETFSQVLKESSCDQSDQPLDFSGYNRQKFKGDFRSFKE 1665
                    |:|.||.| ..:..||..:...|:.:...|                .....:|||..
Yeast   961 --------PIDFSLTL-NPQGTLYCQISLESEKIDAVS----------------SMGRIYRSFSR 1000

Human  1666 RPCGSEDAECTLDL------------RNQPQTISNHVSSRDQIIERDKNQPLAEDSSVH---LSS 1715
                |.|....|.:            |...:|:..|..|           .||.|.:|:   |..
Yeast  1001 ----SRDRAINLIVNKFSDFIAFAFSRTTLKTVCGHHGS-----------ALASDEAVYDAILPL 1050

Human  1716 FHWLQSS------------------------VEEVTTLVHPE------NMTKGSQQA--EETSLV 1748
            |.:|.::                        :|....|:.|.      |:.:.::::  |.|...
Yeast  1051 FDYLNANLNILASELSQRLLFMVMLRAWNLVLENADLLLLPALNSAKVNILRSAKKSLWENTLST 1115

Human  1749 NKVASVFS--VLGASVGSTLKFDKSESLEALAMQKVNQQSD---LAELTNDGFQSLIMSKQLEGN 1808
            .|..|.:.  :..|.:.:..|:     |:||.:...:.:.:   ||||.|:.:|::::.......
Yeast  1116 TKTVSGYGRPLTQAEIEAVFKW-----LDALCVDFFHNKGEGPPLAELKNEYYQNILLIPAFYDK 1175

Human  1809 SPNVEKSLLKDSERQIV 1825
            |    .|.|||..::::
Yeast  1176 S----VSELKDEVQRLI 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13B	NP_001358118.1	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..210
		C1_Munc13-2-like	3208..3289	CDD:410409
		C2B_Munc13	3349..3475	CDD:175993
		MUN	3667..4154	CDD:461870
		C2C_Munc13	4188..4307	CDD:176041
YOR296W	NP_014939.1	C2_Munc13_fungal	856..986	CDD:176008	35/201 (17%)