Protein Alignment UNC13B and PKC1

DIOPT Version :10

• Sequence 1: NP_001358118.1
• Gene: UNC13B / 10497
• HGNCID: 12566
• Length: 4340
• Species: Homo sapiens
• Sequence 2: NP_009445.2
• Gene: PKC1 / 852169
• SGDID: S000000201
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 952
• Identity: 174/952 - (18%)
• Similarity: 296/952 - (31%)
• Gaps: 342/952 - (35%)

Human    80 IALKTIRQSDEEGPGEWSTLEAETLMKDDEIC--------GTRNPTPHKILLDTRFEL-PFDIPE 135
            :.|||.:||..|...|           |:|.|        .|::|..|   :.:|.:| .:|.|.
Yeast    61 LRLKTAQQSQGENGSE-----------DNERCNSKEYGFLSTKSPNEH---IFSRLDLVKYDCPS 111

Human   136 EEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDPD----SAVDD--RDSDYRSE 194
            ...|. .|..:|:       |:..|.|.|.:...|...:....|.|    ||.:.  .:|.||.:
Yeast   112 LAQRI-QYMLQQL-------EFKLQVEKQYQEANTKLTKLYQIDGDQRSSSAAEGGAMESKYRIQ 168

Human   195 TSNSFPPPYHTAS--------QPNASVH----------------------------QFPVPVRSP 223
            ..|.....|...:        |||..:.                            |.|:..|.|
Yeast   169 MLNKALKKYQAINVDFDQFKHQPNDIMDNQQPKFRRKQLTGVLTIGITAARDVDHIQSPMFARKP 233

Human   224 QQLL-------LQGSSRDSCNDSMQSYDLDYPERR-------------------AIRYAQKYDTL 262
            :..:       ::..::.|.||.. |.|...|..:                   ||.:....|..
Yeast   234 ESYVTIKIDDTIKARTKPSRNDRW-SEDFQIPVEKGNEIEITVYDKVNDSLIPVAIMWLLLSDIA 297

Human   263 DRRRKKKSLYNHFEDSERRQY----------GERSETKTNYKSTYSNT------------ENCTL 305
            :..||||:    .:.:|::.:          ...||..:...|||||:            ||.:.
Yeast   298 EEIRKKKA----GQTNEQQGWVNASNINGGSSLASEEGSTLTSTYSNSAIQSTSAKNVQGENTST 358

Human   306 --------------------------CHTEKKQNMGYPVLYPYKNGFVVKSGMQRIKLESHD--- 341
                                      ...|:||.||    ..:::|.::....:..:...|.
Yeast   359 SQISTNSWFVLEPSGQILLTLGFHKSSQIERKQLMG----GLHRHGAIINRKEEIFEQHGHHFVQ 419

Human   342 ---YDLSSC------LRH-----------CEKSSGSNQHVTNFTSLDILEDSTSSTSDELLGSPI 386
               |::..|      ||:           |.|..     .||..:..|.:.||.:..||   :.:
Yeast   420 KSFYNIMCCAYCGDFLRYTGFQCQDCKFLCHKKC-----YTNVVTKCIAKTSTDTDPDE---AKL 476

Human   387 SDKQENLQSPT----------------W---------------HSSNVHHIGDFPEEYYVANSAL 420
            :.:..:...||                |               |:...|.:.||        ..:
Yeast   477 NHRIPHRFLPTSNRGTKWCCHCGYILPWGRHKVRKCSECGIMCHAQCAHLVPDF--------CGM 533

Human   421 PLQRMNCDAKTLGDLSECSIEEITPSSIEEPKEDRIDTMDELQCLVETVSEYLAEKEEEINRFGS 485
            .::..|...||:.|...           .:.|:.|.....:|...:.|.:             ||
Yeast   534 SMEMANKILKTIQDTKR-----------NQEKKKRTVPSAQLGSSIGTAN-------------GS 574

Human   486 -LSKTKKSHKQNSTLDAEQRTPGDQIPPLTIVKNDKDTAISFPELTGVQCAVGSLFSSLTEKVG- 548
             ||.:|.:.:.|:.|..:.|            |:||..:                    .:|||
Yeast   575 DLSPSKLAERANAPLPPQPR------------KHDKTPS--------------------PQKVGR 607

Human   549 -SGTKHLTNSVEKLVSLVPEKTETLNQI----EA-INLGSKPRAMAVLGKDLSMQSPLSSQKDDN 607
             |.||.....::|.:||.....|.||:.    || :|.....:..|..........|
Yeast   608 DSPTKQHDPIIDKRISLQTHGREKLNKFIDENEAYLNFTEGAQQTAEFSSPEKTLDP-------- 664

Human   608 VNIDRHRKTSENEHMGNKTGSLYFQNTTESIAKDLAPQSQSSVIKSVFSRLNPLKIFSEKEETKK 672
                    ||....:|....|:....|.||  ||...:.:..:.|:....:. |:|..:..|.::
Yeast   665 --------TSNRRSLGLTDLSIEHSQTWES--KDDLMRDELELWKAQREEME-LEIKQDSGEIQE 718

Human   673 D------DDQSKP----PRKESFVECGL-----------ELNKREGTL--DNYSSSIIALNGSDE 714
            |      |.::|.    ..|..|.|..|           ::|.....:  |:.|..::      :
Yeast   719 DLEVDHIDLETKQKLDWENKNDFREADLTIDSTHTNPFRDMNSETFQIEQDHASKEVL------Q 777

Human   715 ETTGWFQMPTSENLLSSQVTSEPSNLVSSASKNDESLLEEKLCIDLSLLPDQQKICAKDTPGHPC 779
            ||.......|..:..:.|.:.:.|...:||.....:....|:.:|..:|   .|:..|...|...
Yeast   778 ETVSLAPTSTHASRTTDQQSPQKSQTSTSAKHKKRAAKRRKVSLDNFVL---LKVLGKGNFGKVI 839

Human   780 IAGSRTANKEVFSKPLEEDKVTGNDDFLEPLRKSFSQFLLTS 821
            ::.|:..::....|.|::|.:..|.| :|..|.....|||.:
Yeast   840 LSKSKNTDRLCAIKVLKKDNIIQNHD-IESARAEKKVFLLAT 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13B	NP_001358118.1	C2A_Munc13	1..127	CDD:176040	13/54 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..210		15/68 (22%)
		C1_Munc13-2-like	3208..3289	CDD:410409
		C2B_Munc13	3349..3475	CDD:175993
		MUN	3667..4154	CDD:461870
		C2C_Munc13	4188..4307	CDD:176041
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011	5/10 (50%)
		HR1_PKC-like_2_fungi	110..181	CDD:212010	18/78 (23%)
		C2_fungal_Pkc1p	211..319	CDD:176071	18/112 (16%)
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	10/55 (18%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	7/65 (11%)
		STKc_PKC	828..1145	CDD:270722	14/54 (26%)