|
Human 691 ELNKREGTLDNYSSSIIALNGSDEETTGWFQMPTSENL-LSSQVTSEPSNLVSSA---------- 744
:|.|:|..::.....|.|.|.... |:...|.| |..|.|...|:|:||:
Fly 18 QLLKKELKINTQEKLIFAENALKS------QIKIKEQLRLQQQSTIYASSLLSSSAAGSVRAPLL 76
Human 745 SKNDESLLEEKLCIDL--SLLPDQQKICAKDTPG-------HPCIAGSRTANKEVFSKPLEE--- 797
|:...:.::..:..|| :.:|:.|...:|...| :|.| ..|:.:.|...|:
Fly 77 SQGHLNSIQHNMDFDLAKAQIPEMQPPMSKSPNGLDFSYLSYPSI----NTNESMISIKSEQQLC 137
Human 798 -----------------DKVTGNDDFLEPLRKSFSQFLLTSPETCSKESLSEPVKIRQVEEDGLE 845
||:......||...| |...:.:..|.|.....:::.::|...:|
Fly 138 QSYNSEQHSDYIISDYMDKIATRISLLETELK----FAWRALDLLSTEYGKIWIRLEKLENISIE 198
Human 846 RGSKKDGHSFSFSGKLNLPFFRSLGHSEKQ-QELKEKGSIFPLFKFSFTDSKVTVNDQSLRGSAV 909
:. |..|.| ...:|.|:|: |::..:....||::
Fly 199 QQ--------SVVGNL----VDLIGASKKELQKVDIERMKVPLYQ-------------------- 231
Human 910 TTDEESKKNCH-EDTKHSSIKSSSVPNIHSDLGK---FDSTEE--FKKNDQINCPEDAKLNSIKS 968
||:...... |||....|:|| :.|..| |::.|: ..|:.|....||...::...
Fly 232 --DEDQLLPLEMEDTLDIDIQSS-----NRDFDKNLTFENHEKTFVTKHTQATKSEDLMNSAYAI 289
Human 969 SSVPNIHDDLEKFDSIKEFN-KNDQVNCPEDAKLSSIKSGSAPNTQDNLGKFDSTEE-----FNQ 1027
.|.|| |::| :|| ||..:...: ...:.|..|..:.|...|::.:| ::.
Fly 290 DSHPN-------FENI-DFNGKNLDIGIIK----FGFEKGYEPKQKGNQSDFEAYKESRTKLYSD 342
Human 1028 NDQI---------NSPEDAKFNIIKSDSVTNINNDLGKFGN----IEELNPSDHTAGQNFERDGL 1079
:|.: || |:..::| :|.| :.|::.|.....::.|:|..
Fly 343 SDLMLYERQQFLANS---ARAELMK------------EFLNGRRVLNEISASSGALSKSSEKDKN 392
Human 1080 AIPGVVPKEHITSD---------------PLGEDKNLIQAASSVASDSS-----LECISTTSKST 1124
. |.|:|.:.|: | ...|..|.|:|...:.. :|....|....
Fly 393 L---VKPREPLLSEIDDTYVRRSTCELVSP--SSNNFFQIAASKTGEGGNQVLPIEDTGGTESPA 452
Human 1125 LVNEINEDEVIDKTSKKNTQGSFLSGLFNRFSSAENLSSQELNLKNDDS--HHKNNTPGLISGIF 1187
.:||::| ||...|...:...| |||:...: |: |....|...||.|.
Fly 453 NINEVDE--------------SFYKNLNEAYRDNE-LSSEIFKV---DALLHQSEATHDHISFIR 499
Human 1188 NLLSNSGMIDHKPEEAKFMSLGNMKSLNGDNHLSLDEVPATSCVTSENPKNHVEKHETSSFIEAS 1252
|..::|.::::: .:.::.|...|. .|.:|:.:| |..|:.|.
Fly 500 NQSTSSPVLNNQ----------RVNAITGTQPLQ----TAKACLVTE-PNQHLNKE--------- 540
Human 1253 LLPKENIPLSDAGDDNHYCSPTEKNQQSEKHHPSSENIV--LHCAPSAQLGFLEKSMAKRQMPNH 1315
|::: :.:|||.:..::: |.|. :|:.| ...
Fly 541 --PRKH--------------------RKKKHHTNEMDMINKLKCI-----------LAQAQ-STE 571
Human 1316 VLEAKLHENSNKLNSP-VLNTNILNKSNNYQAFEEMNSPFCFEWDSDIKDLSKNSRKLQPVYYML 1379
:::..:.|..:||:.. |..|...|||:|:.:...:. .||:.:..| .:|.:...:
Fly 572 IIKRDIEELGSKLSDACVKQTETENKSDNHISTSYLK--------DDIRKMLNN--VIQTLLGEI 626
Human 1380 NQNRFLSADACLWLDS-ENSVIN---FCQK----DQNANILEWRTNPNSVIWCDLPYESFNQLAF 1436
|:.:.|.:.:...|.. :|:|.: |.|| |:...:| ..||.:|. |...:|..
Fly 627 NKIKGLQSLSATQLSQLQNAVWSEERFFQKISLVDKKLTLL--LLNPLTVT------EELQRLCI 683
Human 1437 ---NEDYL-----LRGDVWAANSLYGNSGPLPINEANNSLEELPIDLSSSSDHEKTTCPVVDQES 1493
||.:: |:.::.....|.| :||::..|| :|....||. .|
Fly 684 SNTNEKFVLVIKKLKKNIDTLKKLVG-----------SSLDDFKID---NSHANMTTF-----HS 729
Human 1494 LRMDENFVFSSF-------GYEYQEWLSCLEHGVWWPSEDGDYGYYMFHDGQYIYSLLTDSTGQY 1551
|....|...||| .....|.|..|| :::.: .|..:.|..::: ...:.
Fly 730 LNPSHNSNDSSFSAHLLRNNSNLDEQLKILE------TQEIE-----IHRKKKIDEIVS-GLSEE 782
Human 1552 AYLFIPD-SYQEYLDCDLQTNGL----SSITLDDSIISACSFKVLDKEDEIFWYV-----EEEPI 1606
.|.|.|| .|:....|...|:.: .:|..:|..|.:.. |.|::.:.:.:.: |:..:
Fly 783 TYTFNPDMEYKSQHSCTNSTDNIIGFSKNIYNEDEYIKSLR-KSLERHNSMIFLLHLQNPEKHKV 846
Human 1607 -----DDPLD-----LSLALPRSEEPLYLNLETFSQVLKESSCDQSDQPL-DFSGYNRQKFKGDF 1660
|..:| ||...|...:.:||| :..:|:..:....:||..| ..||:
Fly 847 LADINDAQMDSNRASLSPPPPAPTDTVYLN-DAINQITYQQRNGKSDSGLSSMSGW--------- 901
Human 1661 RSFKERPCGSEDAECTLDLRNQPQTISNHVSSRDQIIERDKNQPLAEDSSVHLSSFHWLQSSVEE 1725
|.:::.::.|:|.....:|.:.:..:.::...:.||||: |:||....|.|:
Fly 902 ---------SANSQVSVGLQNYDPACNNILENCSERLQTYHSFPLAEN-----SNFHSFPLSHEQ 952
Human 1726 VTTLVHPENMTKGSQQAEETSLVNKVASVFSVLGASVGST---LKFDKSESLEALAMQKVNQQSD 1787
..| .|.|:.....|..:.:.:::....:..|....: :|::..:|.|......|::..:
Fly 953 AQT----TNQTEFVILEENLNYIYELSKNLPICSAYENKSIFDMKYEICDSNEIGKFSTVDEMLE 1013
Human 1788 LAELTNDGFQSLIMSKQLEGN------SPNVEKSLLKDSERQIVSNVQHPELIKNIRQEFSLNKN 1846
..:| |:..:.....|:|..| :..:..|:.|.::...|: |:.:||: :|
Fly 1014 WDQL-NEPDKQNFSGKRLNSNLMPDLLTAQIPNSISKHNKNTSVN-------IEYVRQK----EN 1066
Human 1847 NHVKKQSLLKSGFQVSQTTPQAKSGVKDDEI---ITTDSISVSPAPQHSGDERENYELPQGQSSK 1908
..:.::|::: |...:|..:|:| ..||.:...|:.....|...:::
Fly 1067 KGMDRRSIIE---------PNIYNGKSEDQICRPCLTDKLVFYPSSNSITDHNSSHD-------- 1114
Human 1909 ESDKTLFKSSLKLFSQEESSVSMTANEKQSSGFLNLFKTQVNKE-GSPNLEKIGDTNVKIPPQEK 1972
....||:: :|::.|| ||.:| .
Fly 1115 ----------FNCLSQQD-------------------QTRIIKEFGSAHL--------------N 1136
Human 1973 KESSGVSNFWGTLGDFFKANVSPIQTTENTSVSSMTIKDEVRS---SPTPMELASQG--AGNFPA 2032
::.:...:: |.|.:.|| .|...|..|:.|.:....|..| ||.......|. .|..||
Fly 1137 QDPTNYLDY--TSGTYSKA--PPEVLTHETNSSHLEFNHESESLFNSPNTSSYCKQKFVPGTSPA 1197
Human 2033 AP----------ISSKGK-ARVRRLNKQTT----IDDSRLEESTRGIQGNDLTEKEVPFRDHLIQ 2082
.| ::...| .||.:.|:..: :....|:...||..|: .|| |.
Fly 1198 KPSKVWKRLNTILADNLKLKRVSKFNRSLSLPGDVQSQGLQRQPRGQAGS------CPF----IH 1252
Human 2083 QSPNSSFSTSSLKESSRESSV----ETSGVTTVTEVSK-SNEISFDTLS-KRNSNEQDHFSDKDW 2141
:..|.:.|...|.:..::..: ...||..|...|. .:.:|.|:.: ||.|:|:.
Fly 1253 KRSNLAGSPVQLSKRIQKLPIRFIGRAKGVPFVRRSSSPDSAVSLDSAADKRFSSEKG------- 1310
Human 2142 SFSMAATSSSQPELSTKKSIFSFLTG---SEKSENRASATLPRAKSQAEGLFTLPSFFSTASSSI 2203
..||:|.|.::| ..|:..|.|..|.|..:.::....:|.|.|:.:
Fly 1311 --------------LKKKTISSKMSGLMQKAKTYKRHSFVLRRGCNMSDSELEMPDFVSSGN--- 1358
Human 2204 KKDASHSSSTFSFFSLSFLDQKKETSGEKQSISTVVPVTSQPCKKTNVFVESGSTMTRESSSGHR 2268
::.|..|||
Fly 1359 --------------------------------------------------DNSSISTRE------ 1367
Human 2269 DSIAQEVVHEQQMAPCISINNTIEVTSLADELSVDKDCQEKLSSNIVPGTSVDFQMNELQKDIIP 2333
|.:|.:|||....::.:....|..| .|.|.|::.....|..::.|
Fly 1368 ----------------ILLNQSIEVEDEQEDFNYKNRCDSK----SVLGGSIEKLNGNLTNNLFP 1412
Human 2334 PSPEFQAQAETFLTGPENLGI---APHEEEAFNHKAFPSDSLSNSFSHAKQLIEKFNDLDTCTNC 2395
...:.:. :..|..|.: .|..::.:::| |||:.||
Fly 1413 IVGDLKK-----IQSPLPLAVLTEIPSYKDEYSNK---SDSIKNS-------------------- 1449
Human 2396 HQNEKFTTDPVNLPLEKAPDEVLPQILEPASSSPEPGCAGNLQNQDADKEEDKFALGSSVDMLSG 2460
|:| :|:|| .|..|...|....:|.:.||..|.:|
Fly 1450 -------------PIE------MPKIL------LETACNQELNLAHSDDDVDKNILANS------ 1483
Human 2461 FVTKVKSFSGSLIEPPKTLSGLFSSPKSPKKNSFFSLASDV--SSQPLKGELFGIFKSPKPEPYK 2523
.|.: :..|. ||:...| :|:|. .:|......
Fly 1484 ----AKDY----VNAPT-----------------FSILKTVEDASEPT--------MTPLHTTTT 1515
Human 2524 QESSLPATS--WLQNGC----SRDAVGSVPPERREAAFTALSSESTLSDCRMTVVSAKPESDILT 2582
..|||..|| |:...| :....|| |.:....:..|..|||..| ....|..|.|
Fly 1516 TNSSLNVTSALWVTQQCLDLPNYPGWGS----REDDDNRSQHSARTLSSSR----RQSTEDSIDT 1572
Human 2583 DDPKLTTKMEDNNTPENILEPQRSETINTSSFSGDDTGQGVLSLSDEGDMGILQATDTEASLEAE 2647
||.....::.. ||.|..:..:.|: :.|...:.|..:|
Fly 1573 DDEYFYYELRQ-------LEEQEKQRAHNSA---------IPSCERQNDNDVL------------ 1609
Human 2648 NFALPAQLHPDPTCIAEELPPPIQPPLPLEPEPAIQTASTNQDLLELHPASSLETDTMLFNDASV 2712
|:...|| :|......|........:...|.::| |.
Fly 1610 -FSQIGQL--------------------------LQNDVNGGDGFRHSNGCNDGEDAIIF---SP 1644
Human 2713 SQSTTLETEGHFSHPLLEDPVLAARESCEIIHAQKDPPVVPQETEQSRPRFEIPNVTTWPKLRLP 2777
|:|..|.....| :|...::... |:|.
Fly 1645 SESVKLRMSEVF------------KELKSVVSLN-------------------PSVN-------- 1670
Human 2778 SSATNHGKPLSSFFSSPLPSGNRAAETGLMSSFKKLSTLFEGSS-----EGKGSVLASDSKLGFG 2837
:.||..|.|: :..:::||.|:.:..| .|...:.|||......
Fly 1671 NDATFEGVPI------------------VKPTYEKLETVSDLHSAWQDVNGDLQIAASDIDSNED 1717
Human 2838 KVDLSFPWPKENKGVPEQMPTESSPPVL----VTSSDQDLNSSEANKALKSSQISGASAQPGKVY 2898
.|. ||| .:.||.:....| ..:.|:.:|.| |::..|.:|.......
Fly 1718 LVG--------NKG--RETPTYNKQRKLRRLKKKTRDRKINIS------KNATSSSSSCHSENEC 1766
Human 2899 TQPSG-TSEQLVASPEVCAQGLSGSGEGGNQQEISASGEHWDTKANLSSPACPSGKHEEEPSTVS 2962
..|.| .:::.||..: :.:..|:.|.|:.....||.|.||. ..:|
Fly 1767 NTPLGQCTQKSVAEKD--------TNDISNKSEASSETSGPDTPAELSD------------VDIS 1811
Human 2963 EIFHQL---EKQEEEAVPASTDSDLNVQQPVTLN-DIKEPMTNKSPTSSSRYGSSC--NVSQGS- 3020
|..:.| :.|..:.:..::.|.|.|.:...|. |:...:.|: |..:|:|.:.. |::..|
Fly 1812 ETENGLRADDGQNIDNMRGNSGSLLKVNRKYLLQFDVDHSLINQ-PLETSQYNTHMLENITSASI 1875
Human 3021 -SQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQE---------KPLEVTGQAEKE 3075
||..::| :.::.| .|||: ||....|.:. |.|:...:.:.|
Fly 1876 PSQNRQID-----------SKTLMS-QSSHA---DGSQAVGNETAVGLSSSKWKLLKTLKERKIE 1925
Human 3076 AACEPKEMKEDATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIP 3140
......::||| :::..:| :|...| .:|.|:....|
Fly 1926 EKNNQDKIKED-------EMIKDRD-----------KNGGGP------------GEVGLRTNGHP 1960
Human 3141 DDGDPSLPQWLPEGPAGGLY-GIDSMPDLR-RKKPLPLVSDLSL----VQSRKAGITSAMATRTS 3199
.|.. .| .||||||:| |:|.:||||:|.| ...|.||:|||: .|.:
Fly 1961 GDNP--------------FYSNIDSMPDIRPRRKSIPLVSELVLKTMAATKRNAGLTSAV-PRAT 2010
Human 3200 LKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKC 3264
|.||:||.|||||.|||||||||.||||||.:||||:||||||||||||||||||:||:||||||
Fly 2011 LNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTECGVKC 2075
Human 3265 HEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAH 3329
||||:|||||||||||||||.||||||:..:||.|||||||.|||.||||||:||.||:|.:.:|
Fly 2076 HEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELIRAVFSVEEKSH 2140
Human 3330 VQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNP 3394
...||.||||||||||||||||.|||:|||||.||||:|:|||||||||||.||||:|:...|||
Fly 2141 AGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNP 2205
Human 3395 VWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLE 3459
||.||||||||||||||||||||||:|:||:::|:|.||||||||||||||||||||||||||||
Fly 2206 VWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLE 2270
Human 3460 KRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWK 3524
||||||||||||||.|||||||||||||||||||||||||||||.: :.:|.|::|..:||||||
Fly 2271 KRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYLCE-ENTGMVKLPTQKGDDAWK 2334
Human 3525 VYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN 3589
:||||..:||||||:||||||:||||||||.|||:||:|||||||||||||||||||||||||:.
Fly 2335 LYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASSA 2399
Human 3590 VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRM 3654
|||||||||||||||:|||||||||||||||||.|||||||.|||:|.|||||||||||||||||
Fly 2400 VSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSPEKLMDLKSTVDLLTSITFFRM 2464
Human 3655 KVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQL---KQELPPEEQGPSIRNLDF 3716
|||||.||||||.||||||||||.|||:::|.||::||:|::|: :.:..|::..|.:.::||
Fly 2465 KVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPDDHEPKLDSVDF 2529
Human 3717 WPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSAD 3781
|.|||.||||:|:||||||..||||||||||:|::||..||||||.||||||||||:..||||:.
Fly 2530 WHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWHLFAVDMKYALEEHEQHRLCKSSA 2594
Human 3782 YMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQ 3846
||||||:||||::.||:::|..:|.||:||||||.||:|||:||:|||||:|.||.:||||||||
Fly 2595 YMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNENDDVSLEYLHGAFKRDKKDGFQ 2659
Human 3847 QTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPA 3911
::|||||||.|||||||||.|.|:::.|||||||.|...|||||||||.|||:.||||:..:||.
Fly 2660 KSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAYADIVKLEFPE 2724
Human 3912 YCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQ 3976
:...|::.||||||:||||||||||||:|||.:|:.:||:.|||||..||:.||:|:..|..|.:
Fly 2725 HMKDERIACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKELQQNLNSALDDLASQFAISLE 2789
Human 3977 VRIDECVRQMADILGQVRG------TGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEK 4035
.||.:.||::.|:|..::| .||.:.. |.:.|.:||.|||||||.|||:|||:|..|||
Fly 2790 PRITQSVRELGDMLLSIKGGSGTLAAGNLAAQ-RNAVAVEADEVLRPLMDLLDGSLTLYAQSCEK 2853
Human 4036 TVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIF----TAAKELSHLSKLKD-------HMV 4089
|||||:|||||::||..:|:.|||||:||:| ::| ..||.|:..:|::| ||.
Fly 2854 TVLKRLLKELWKIVMRILEKTIVLPPMTDKT---MMFKHLTDNAKNLASNAKIEDMGRLFKSHMA 2915
Human 4090 ----------------REETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRY 4138
:|..:||:||||||||:|||||||||||||||||||||||||:||||||
Fly 2916 GKQDVKSALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKTFLEKSPELQSLRY 2980
Human 4139 ALSLYTQTTDTLIKTFVRSQTTQGSGVD-----DPVGEVSIQVDLFTHPGTGEHKVTVKVVAAND 4198
|||||||.||||||||:.||..: || :.|||:|:|:|||:|||||||||.||||||||
Fly 2981 ALSLYTQMTDTLIKTFISSQVHE---VDLENSEESVGEISVQIDLFSHPGTGEHKVNVKVVAAND 3042
Human 4199 LKWQ-TAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQIC 4262
|||| .:|||||||::.::|||..:|||||.||||||||:|||||:|.|.:||||..:.:||.||
Fly 3043 LKWQIPSGMFRPFVDINLIGPHLQEKKRKFATKSKSNNWSPKYNESFSFTIGNEEQLDFFELHIC 3107
Human 4263 VKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFV 4327
||||||||:||::|:||:||:|::.|||.|||.||.|:|.|||||.|||||||||:|||||:|||
Fly 3108 VKDYCFARDDRLVGVAVIPLKDISEKGSVACWLPLMRRIEMDETGWTILRILSQRNNDEVAKEFV 3172
Human 4328 KLKSESR 4334
|||||.|
Fly 3173 KLKSEIR 3179
| 
