Protein Alignment UNC13B and unc-13

DIOPT Version :10

• Sequence 1: NP_001358118.1
• Gene: UNC13B / 10497
• HGNCID: 12566
• Length: 4340
• Species: Homo sapiens
• Sequence 2: NP_001021873.1
• Gene: unc-13 / 172497
• WormBaseID: WBGene00006752
• Length: 2155
• Species: Caenorhabditis elegans
• Alignment Length: 2186
• Identity: 912/2186 - (41%)
• Similarity: 1224/2186 - (55%)
• Gaps: 350/2186 - (16%)

Human  2318 TSVDFQMNELQKDIIPPSPEFQAQ--AETFLTGPENLGIAPHEEEAFNHKAFPSDS--------- 2371
            |.|.|   ||..|:.....:.|::  |...|...:.||...|....|||.....||
 Worm   140 TDVRF---ELPFDVQGHDEDIQSRLLALNGLIEHDQLGPNNHHRAPFNHSGLSEDSDYTSDVSVP 201

Human  2372 ------LSNSFSH----------AKQLI------------------------EKFNDLDTCTNCH 2396
                  ..||.:|          .:||:                        :.:|..||   ..
 Worm   202 VNHHQLHPNSSAHQYESHLHPHRTRQLLHTREGAASYEDEEDAYHARHQPESDDYNHQDT---YD 263

Human  2397 QNEKFTTDPVNLPLEKAPDEVLPQILEPASSSPEPGCAGNLQN---QDADKEEDKFALGSSVDML 2458
            |:..:..|      |.||.                |.:...|.   ||.|::..        ::.
 Worm   264 QHSSYYND------EYAPS----------------GSSSQYQRQGYQDQDQQHQ--------NIY 298

Human  2459 SGFVTKVKSFSGSLIEPPKTLSGLFSSPKSPKKNSFFSLASDVSSQPL-KGELFGIFKSPKPEPY 2522
            ...||.|:.|..|.: ||...|   |..:..:...:.|.:.:....|: .|.|      |:.||.
 Worm   299 EDTVTPVREFGESAV-PPAASS---SRRQFDQVYGYASSSEERYDTPMSSGRL------PRDEPI 353

Human  2523 KQESSLPATSWLQNGCSRDAVGSVPPERREAAFTALSSE-STL----SDCRMTVVSAKP-----E 2577
            .:.|. |...:.|||...:....:.|...|..|...::: ||.    :|.|....|:..     |
 Worm   354 LEHSE-PEYVYDQNGYPEEDNYGINPTYSEDHFEGQTNDYSTTHQEPNDFRNDYNSSYQREYWNE 417

Human  2578 SDILTDDPK-----LTTKMEDNNTPENILEPQRSETINTSSFSGDDTGQGVLSLSDEGDMGILQA 2637
            |:.|:.:.:     :.|.......|.....|..|:..|..    |||.|     .||.|.|...:
 Worm   418 SEPLSYNSRPPNGHIRTGANTWREPSTSSRPTSSQAWNYQ----DDTHQ-----YDEVDRGSRVS 473

Human  2638 TDTEASLEAENFALPAQLHPDPT--CIAEELPPPIQPPLPLEPE----PAIQTASTNQDLLELH- 2695
            .....|::..:       .|..:  ...:|:....:|..|....    .:||.....:|..:.|
 Worm   474 FTRTPSVDRTD-------RPSESGGGFYDEMSESGRPGRPDSHHNWRYDSIQEEDNEKDNWKQHV 531

Human  2696 -----PASSLETDTMLFNDASV---------SQSTTLETEGHFSHPLLEDPVLAARESCEIIHAQ 2746
                 .....:.|....||.|.         |.||   .:..|.:.::...:
 Worm   532 EGYEEGQEEKQKDNQKPNDHSAASPQDHYHRSDST---AQQDFGNNIVRQTI------------- 580

Human  2747 KDPPVVPQETEQSRPRFEIPNVTTW--------PKLRLPSS-----ATNHGKPLSSFF---SSPL 2795
                   ||.|:.|...|:     |        ..|.:.||     ||..|..|.:.|   ....
 Worm   581 -------QEEEEKRNYQEL-----WHNAYKRVCADLGIKSSQASLVATTGGTLLQNLFLYRPKLA 633

Human  2796 PSGNRAAETGLMSSFKKLSTLFEGSSEGKGSVLASDSKLGFGKVDLSFPWPKENKGVPEQMPTES 2860
            |:|:.|..:...|.        .|::....:...:::.:...::|.:...|.:    |.:.|:.|
 Worm   634 PAGHGATASQFQSP--------AGATRFYANHNNNNNNVSKNELDSTTETPPD----PSRTPSTS 686

Human  2861 S----PPVLVTSSDQD-LNSSEANKALKSSQISGASAQPGKVYTQPSGTSEQLVAS--------- 2911
            |    |.:.|..|... |||...:....:.||..:..:..:.|...:|..|::..:
 Worm   687 SMNPVPSLAVPMSPGPYLNSDPPSPVSPNPQIKRSIYRIKESYEDRNGGRERIYTTNLVSVYLEK 751

Human  2912 ---PEVCAQGLSGSGEGGNQQEISASGEHWDTKANLSSPACPSGKHEEEPSTVSEIFHQLEKQEE 2973
               |:...:|.|||.. ..|.||....:..:.::|:..|                         :
 Worm   752 MKPPDELEEGSSGSMR-ETQNEIKNGTQLHNAESNIFFP-------------------------Q 790

Human  2974 EAVPASTDSDLNVQQPVTLN--DIKEPMTNKSPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDH 3036
            ::||.|          ::.|  ::|......|.|||:....|....|..|:.:      .:|.|.
 Worm   791 DSVPKS----------ISYNAGNLKNTSITTSKTSSAITNHSSLPPQPPSKPA------SRDSDP 839

Human  3037 RETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPD-----LV 3096
            .:  .:.:...|....|..::....:.|...|  :.:|..:| |...|.:.|.||...     :.
 Worm   840 MK--QLLTFSKSFKKVRRVRSAMPRRRKRKRV--KIKKSRSC-PILWKTEKTPHPMKSKSMTCIR 899

Human  3097 LQKDHFLGP--------QESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPE 3153
            :.|...:.|        :...|.....|   .::||      |.:..|....|.|..::......
 Worm   900 IPKKTVIAPLRKEIKIVRMKPPAARCES---DSKAH------KKKNLLDVYKDMGKSTVLDGNGS 955

Human  3154 GPAGGLY-GIDSMPDL---RRKKPLPLVSDLSL--VQSRKAGITSAMATRTSLKDEELKSHVYKK 3212
            ..|...| .||:.|::   |.|..:||||:|.|  :.:::|....|.|.||:..|.|||:|||||
 Worm   956 SAANAFYKSIDAAPNMNVARTKTSIPLVSELVLKTMATKRAQAGLANAARTTFSDTELKTHVYKK 1020

Human  3213 TLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCL 3277
            ||||||||||.||||||...|..|||:||||||||||:||||:||::|.||.|:||::||:||||
 Worm  1021 TLQALIYPISATTPHNFATTTFQTPTFCYECEGLLWGLARQGLRCTQCQVKVHDKCRELLSADCL 1085

Human  3278 QRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLD 3342
            |||||||.|||..||||:::..::|||||:|:||||:|::||.||.|::....:.:||||.|:|:
 Worm  1086 QRAAEKSTKHGEADRTQSLVNVIRDRMKIQEQNKPEVFQMIRTVFDVDENIQKETLKTVKASILE 1150

Human  3343 GTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS 3407
            |:||||||||:||:|||||.||||||.||||||.||.|||:||:||...|||||.||||||||||
 Worm  1151 GSSKWSAKITLTVLCAQGLIAKDKTGKSDPYVTAQVGKTKRRTRTIHQELNPVWNEKFHFECHNS 1215

Human  3408 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIR 3472
            :|||||||||||:|:||:::|:|.||||||||||:||||||||||||||||||||||||||||||
 Worm  1216 TDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTVIEVRTLSGEMDVWYNLEKRTDKSAVSGAIR 1280

Human  3473 LQISVEIKGEEKVAPYHVQYTCLHENLF--HYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIV 3535
            |.|:||||||||:||||||||||||:||  |.:.:     .|::|:.||:|:|||.|.||.|||.
 Worm  1281 LHINVEIKGEEKLAPYHVQYTCLHEHLFAAHCVDE-----EVKLPKVRGEDSWKVCFQETGQEIA 1340

Human  3536 DEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASN 3600
            :|||||||||||||||||||||.::|||.|||||:||||||||||||||||::.|||.|||||||
 Worm  1341 EEFAMRYGIESIYQAMTHFACLCTRYMCAGVPAVLSTLLANINAYYAHTTATSAVSAPDRFAASN 1405

Human  3601 FGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRA 3665
            ||||||||||||||||||||||.|||:||:.||.:|||||||||||||||||||||.||.|||||
 Worm  1406 FGKERFVKLLDQLHNSLRIDLSAYRNHFPSSSPAKLQDLKSTVDLLTSITFFRMKVLELASPPRA 1470

Human  3666 SQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSI-RNLDFWPKLITLIVSIIE 3729
            |.||::|.|||:..||:.:|.:|                .||.|.: .::.||.:.|..|:.:||
 Worm  1471 STVVRECAKACMQQTYQLMFESC----------------AEQFPILDTSVQFWYEFIDYIMRVIE 1519

Human  3730 EDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHN 3794
            ||:.:|||.|||||||||||.:|||.:|.::..|:|.|||||.:...||:.:||||:||||..:.
 Worm  1520 EDQKNYTPALNQFPQELNVGNLSAETLWSMYKNDLKMALEEHAQKKRCKTPEYMNLYFKVKGFYF 1584

Human  3795 EYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVV 3859
            :||.||...:..:||:||||..||:.||:||::.|::.||.|...||.|.|.|||||..||.|||
 Worm  1585 KYVADLSTYKSSIPEFPAWFIPFVMDWLNENDEHSMDILRNAYNVDKADNFPQTSEHTKFSNSVV 1649

Human  3860 DVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMN 3924
            |||||||.:.:::::::||:|.:.|..|:||:||:.|||:.|||::.||||.:...|||.|||||
 Worm  1650 DVFTQLNAALKLLKQMDCPNPEVAADMMKRFSKTLNKVLLAYADMVQKDFPKFAHDEKLACILMN 1714

Human  3925 NVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADI 3989
            |||||||||||::|.|||.|||......|..||.|||:|||.||..|..:.:..|.|...::..:
 Worm  1715 NVQQLRVQLEKIYETMGGAELDEHIGQVLTVLQKKLNSVLDRLSAEFVTTLEPHIHEQTIKLGML 1779

Human  3990 LGQVRGTGNASPDARASAAQ-DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTM 4053
            |.:::|     |..:.:..| :||:||.||||.|:|:|..:|..|||||||.:|||||::.:..|
 Worm  1780 LVKIKG-----PQLQKTQVQPEADAVLEPLMDLLEGSLRRYADQCEKTVLKYILKELWKITIVNM 1839

Human  4054 ERMIVLPPLTDQT------------GTQLIFTAAKELSHLSKLKD--HMVREETRNLTPKQCAVL 4104
            |:.:|||||:|:.            .|:|:.|..:.:..::.:||  .|.||..::|||:||.||
 Worm  1840 EKRVVLPPLSDKALLKQLPNAKIGDVTKLMSTNIQSIKGMNSVKDMMDMARESEKSLTPRQCTVL 1904

Human  4105 DLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQG-SGVDDP 4168
            |.|||.||..|||.|.||||:|.||||:||||:||||||||||:.|||||:.||..|. ...:.|
 Worm  1905 DCALDAIKDSFHASGKGLKKSFFEKSPELQSLKYALSLYTQTTEQLIKTFITSQRQQDLPSQEQP 1969

Human  4169 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKS 4233
            |||||:|||||:||||||.|||||::|||||:|||:..|:|||||.:||||.||||||::||:|:
 Worm  1970 VGEVSVQVDLFSHPGTGEQKVTVKILAANDLRWQTSSAFKPFVEVHLVGPHLSDKKRKWSTKTKA 2034

Human  4234 NNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAK-GSCACWCPL 4297
            .|||||:||||||.||||..||.|||...||||||||:|||:|:.|:.|..|..: ||||.|..|
 Worm  2035 GNWAPKFNETFHFFLGNEGEPEHYELMFQVKDYCFARDDRVVGVGVLQLSSVVDQAGSCAMWVQL 2099

Human  4298 GRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEE 4338
            |.::|:|||||.:|||||||..||||::||:||:|.|...|
 Worm  2100 GTRLHIDETGLILLRILSQRQTDEVAKDFVRLKTECRYETE 2140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13B	NP_001358118.1	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..210
		C1_Munc13-2-like	3208..3289	CDD:410409	62/80 (78%)
		C2B_Munc13	3349..3475	CDD:175993	104/125 (83%)
		MUN	3667..4154	CDD:461870	243/502 (48%)
		C2C_Munc13	4188..4307	CDD:176041	77/119 (65%)
unc-13	NP_001021873.1	C2A_Munc13	18..144	CDD:176040	2/3 (67%)
		DMP1	<309..>591	CDD:462128	62/331 (19%)
		C1	1016..1096	CDD:412127	61/79 (77%)
		C2B_Munc13	1157..1283	CDD:175993	104/125 (83%)
		MUN	1472..1954	CDD:461870	243/502 (48%)
		C2C_Munc13	1989..2109	CDD:176041	77/119 (65%)