DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STK25 and SPS1

DIOPT Version :9

Sequence 1:	NP_001258906.1	Gene:	STK25 / 10494	HGNCID:	11404	Length:	426	Species:	Homo sapiens
Sequence 2:	NP_010811.1	Gene:	SPS1 / 852135	SGDID:	S000002931	Length:	490	Species:	Saccharomyces cerevisiae

Alignment Length:	442	Identity:	169/442 - (38%)
Similarity:	234/442 - (52%)	Gaps:	70/442 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    12 SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSP 76
            ||..|.:|::....||:|:||:|||.:|..|:|:||||:::||.::::||.:.|||..|::..||
Yeast    10 SRTPPSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSP 74

Human    77 YITRYFGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIATILREILKGLDYLHSERKIH 138
            .||.|..:.|:...:||:|||.||||..||||   ...|.|..::.|:.|:..||.|||.:||||
Yeast    75 LITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIH 139

Human   139 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--KQSAYDFKADIWSL 201
            |||||||:||:|:|.|||.||||:|.:..| :||:||||||:||||||:  :...|:.|||||||
Yeast   140 RDIKAANILLNEEGMVKLGDFGVSGHIRST-LKRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSL 203

Human   202 GITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLK 266
            |||..||.||.||.|...||:|:..:||..||.|:|..|...|:||..||.|.|..||:|..||.
Yeast   204 GITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSAYNLLS 268

Human   267 HKFI---------------------TRYTKKTSFLTELIDR-YK-----RWKSEGHGEESSSEDS 304
            .:|:                     .||||...:  .|.:| ||     |.|...:.|.:....:
Yeast   269 FEFVKNITITNLKSDVDLIKQKKVQERYTKVPKY--PLQNRLYKNSNTVRGKEFWNFESTRLSTT 331

Human   305 DIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGEL 369
            .|..|    |..||      .:.||.|.|:..:......:...|: ..|.|.......:|||
Yeast   332 QISKE----ELSPI------TQDSPTSSLNMESPYLLHGQTVTPI-TNPSSSSFRKCTQPVF--- 382

Human   370 KEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRNH 421
                           ||::...: :..||....:     .|.|...:||:.|
Yeast   383 ---------------ELDSGMDI-DSGCPNAQAE-----TEIVPLSNHNKKH 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK25	NP_001258906.1	STKc_STK25	15..291	CDD:270810	141/307 (46%)
STK25	NP_001258906.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..355		13/63 (21%)
SPS1	NP_010811.1	STKc_MST3_like	16..291	CDD:270786	131/275 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0201
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I697
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	1	1.000	-	-		otm52723
orthoMCL	1	0.900	-	-		OOG6_100860
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R966
SonicParanoid	1	1.000	-	-		X488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790