Protein Alignment STK25 and GckIII

DIOPT Version :10

• Sequence 1: NP_006365.2
• Gene: STK25 / 10494
• HGNCID: 11404
• Length: 426
• Species: Homo sapiens
• Sequence 2: NP_650596.1
• Gene: GckIII / 42064
• FlyBaseID: FBgn0266465
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 275/626 - (43%)
• Similarity: 325/626 - (51%)
• Gaps: 221/626 - (35%)

Human    13 RVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPY 77
            :||||.:|||.:||||||||||:|||||.|::||||||||||||||||:||||||.|||||||||
  Fly     6 KVDPELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPY 70

Human    78 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIK 142
            :|:|:||:||.||||||||||||||||||:|.|..||.:|..||||:||||||||||||:|||||
  Fly    71 VTKYYGSFLKGTKLWIIMEYLGGGSALDLMKAGSFEEMHIGIILREVLKGLDYLHSERKLHRDIK 135

Human   143 AANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIE 207
            ||||||||||||||||||||||||:|..||||||||||||||||||||.||.|||||||||||||
  Fly   136 AANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIE 200

Human   208 LAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
            |||||||||:|||||||||||||:||.|.|.::|.||:||||||||||..|||||||||:.||.:
  Fly   201 LAKGEPPNSELHPMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIKK 265

Human   273 YTKKTSFLTELIDRYKRWK-SEGHGEESSSEDSDIDGEAEDG--EQGPIW--------------- 319
             .||.::|.:||||:|:|| |:|...|:.||:||.|.:|:.|  .|...|
  Fly   266 -AKKNAYLIDLIDRFKKWKVSKGDESETESENSDSDSDAKQGGSSQDEPWIMTVKGLHINSAPRA 329

Human   320 ----------------------------------------------------------------- 319
                                                                             
  Fly   330 GVNSFQLQEHELTMQKLMQTTHSPAGGGGVQASPAANALSSSVSAVAASASSVSVITANEGVSSA 394

Human   320 -TFPP----------------TIR---------------PSPHSKLHKGTALHSSQK--PAEPVK 350
             ..||                .||               |.|.|.....:|....||  .::|..
  Fly   395 SALPPQNSHVHNHNHNNINNNNIRNLSNKHATTTMLNAAPPPSSVTSSSSASELQQKRSSSKPEL 459

Human   351 RQPR------------------------------------------------------------- 354
            ||.|
  Fly   460 RQSRSAAPLDQVEDRRASLGLPLQSSVPTPSTAEQQQQRRSSQRESFHANNAALVASCSSSSNNH 524

Human   355 ---------------------------SQCLSTLVRPVFGELKEKHKQSGGSVGA---------- 382
                                       |.||:..:.||..:::.|: ..|||.|:
  Fly   525 SHEEHVATNHASHVKHSGAGQRLVQTNSACLNNFLFPVLSDIQRKY-SGGGSAGSGGSGGRNIGV 588

Human   383 ---LEELENAFSLAEESCPGISDKLMVHLVER-VQRFSHNR 419
               :.:|::.|.|||.|.||:||..|..|:.. |..:|..|
  Fly   589 GSDIGDLKSVFELAERSSPGVSDLFMKELIHMLVPGYSETR 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK25	NP_006365.2	STKc_STK25	15..291	CDD:270810	221/275 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..355		27/268 (10%)
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	218/271 (80%)