DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SYNCRIP and MRD1

DIOPT Version :9

Sequence 1:NP_006363.4 Gene:SYNCRIP / 10492 HGNCID:16918 Length:623 Species:Homo sapiens
Sequence 2:NP_015437.1 Gene:MRD1 / 856228 SGDID:S000006316 Length:887 Species:Saccharomyces cerevisiae


Alignment Length:531 Identity:110/531 - (20%)
Similarity:181/531 - (34%) Gaps:179/531 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    16 DTTSAV-----IHSENFQTLLDAGLP--QKVAEKLDEIYVAG--LVAHSDLDERAIEALKEF--- 68
            |:.:||     :..:.||..|...||  :|.:.:|||..:..  |....:|..:|..:.:.|   
Yeast   395 DSKNAVNAYVELDKQIFQGRLLHILPGEEKKSHRLDEFDLKNMPLKKQKELKRKAAASRQTFSWN 459

Human    69 ----NED---GALAVLQQFKDSDLSHVQNKS---------AFLCGVMKTYRQREKQGTKVADSSK 117
                |:|   |::|.....:.|.|...:|.|         |.:.|.::.|.:           ||
Yeast   460 SLYMNQDAVLGSVAAKLGLEKSQLIDAENSSSAVKQALAEAHVIGDVRKYFE-----------SK 513

Human   118 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLF 182
            |.|..|...|         .:|.||      .|.|           |.|...|.....:||..:|
Yeast   514 GVDLTKFSQL---------KSTNQR------DDKV-----------ILVKNFPFGTTREELGEMF 552

Human   183 EKAGPIWDLRLMMDP-----------LTGLNRGYAFVTF----------------C-TKEAAQEA 219
            ...|.:  .||:|.|           .|.....:..:::                | ||.|  ||
Yeast   553 LPYGKL--ERLLMPPAGTIAIVQFRDTTSARAAFTKLSYKRFKDGIIYLERGPKDCFTKPA--EA 613

Human   220 VKLYNNHEIR--------------------------SGKHIGVCISVANNRLFVGSIPKSKTKEQ 258
            ..|.||...:                          |..|....|......:|:.::..|.|.:.
Yeast   614 DDLINNTSAKEEENPVEVKPSSNDLMEANKDVTEGSSNAHDEDVIDGPTVSIFIKNLNFSTTNQN 678

Human   259 ILEEFSKVTEGLTDVILYHQPDDKKKNR----GFCFLEY------------------EDHKTAAQ 301
            :.:.| ||..|.....:..:||.|.:.:    ||.|:|:                  :.||...:
Yeast   679 LTDRF-KVFTGFVVAQVKTKPDPKHQGKTLSMGFGFVEFRTKEQANAVIAAMDGTVIDGHKIQLK 742

Human   302 A--RRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKL 364
            .  |:...||..|...|                  .|...:.|:||....|.:.:.:.|:.||:|
Yeast   743 LSHRQASQSGNTKTKSN------------------KKSGKIIVKNLPFEATRKDVFELFNSFGQL 789

Human   365 ERV-------KKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAK------PPDQKRKER 416
            :.|       |..:.:||:.|.....|..||::::|..|.|..:.:.:|:      ..:..|..:
Yeast   790 KSVRVPKKFDKSARGFAFVEFLLPKEAENAMDQLHGVHLLGRRLVMQYAEEDAVDAEEEIARMTK 854

Human   417 KAQRQAAKNQM 427
            |.::|.|.|:|
Yeast   855 KVRKQVATNEM 865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SYNCRIPNP_006363.4 NURR_hnRNPQ 23..107 CDD:410954 24/106 (23%)
hnRNP-R-Q 103..615 CDD:273732 83/416 (20%)
Interaction with APOBEC1 400..561 7/34 (21%)
8 X 3 AA repeats of R-G-G 448..559
3 X 4 AA repeats of Y-Y-G-Y 460..488
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..623
Interaction with SMN. /evidence=ECO:0000269|PubMed:11574476 518..549
Bipartite nuclear localization signal. /evidence=ECO:0000255 564..578
MRD1NP_015437.1 RRM4_MRD1 663..746 CDD:409758 16/83 (19%)
RRM5_MRD1 763..837 CDD:241014 19/73 (26%)
RRM1_RBM19_MRD1 2..92 CDD:409754
RRM 222..612 CDD:223796 54/257 (21%)
RRM2_MRD1 343..421 CDD:409982 7/25 (28%)
RRM3_MRD1 532..603 CDD:241012 13/83 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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