DRSC/TRiP Functional Genomics Resources

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Protein Alignment SYNCRIP and PUB1

DIOPT Version :9

Sequence 1:NP_006363.4 Gene:SYNCRIP / 10492 HGNCID:16918 Length:623 Species:Homo sapiens
Sequence 2:NP_014382.1 Gene:PUB1 / 855716 SGDID:S000004961 Length:453 Species:Saccharomyces cerevisiae


Alignment Length:255 Identity:61/255 - (23%)
Similarity:100/255 - (39%) Gaps:50/255 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   245 LFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSG 309
            |:||::.|:.| |.||:::.:|...:.::.:  ..|...||..:.|:||.....|..|.:.| :|
Yeast    77 LYVGNLDKAIT-EDILKQYFQVGGPIANIKI--MIDKNNKNVNYAFVEYHQSHDANIALQTL-NG 137

Human   310 KVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKL--------ER 366
            | ::..|:..:.||...:....:....   |||.:|...|.:|.|..||..|...        .:
Yeast   138 K-QIENNIVKINWAFQSQQSSSDDTFN---LFVGDLNVNVDDETLRNAFKDFPSYLSGHVMWDMQ 198

Human   367 VKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDY 431
            ....:.|.|:.|..:|.|..||:.|.|:||.|..:.|.:|...|........||:...|.....:
Yeast   199 TGSSRGYGFVSFTSQDDAQNAMDSMQGQDLNGRPLRINWAAKRDNNNNNNYQQRRNYGNNNRGGF 263

Human   432 YYYG-------------------------PPH--------MPPPTRGRGRGGRGGYGYPP 458
            ..|.                         ||.        ||.|::|:.:..: ..|.||
Yeast   264 RQYNSNNNNNMNMGMNMNMNMNMNNSRGMPPSSMGMPIGAMPLPSQGQPQQSQ-TIGLPP 322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SYNCRIPNP_006363.4 NURR_hnRNPQ 23..107 CDD:410954
hnRNP-R-Q 103..615 CDD:273732 61/255 (24%)
Interaction with APOBEC1 400..561 16/92 (17%)
8 X 3 AA repeats of R-G-G 448..559 3/11 (27%)
3 X 4 AA repeats of Y-Y-G-Y 460..488
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..623
Interaction with SMN. /evidence=ECO:0000269|PubMed:11574476 518..549
Bipartite nuclear localization signal. /evidence=ECO:0000255 564..578
PUB1NP_014382.1 RRM1_PUB1 77..150 CDD:410026 21/77 (27%)
RRM2_PUB1 161..240 CDD:410031 24/81 (30%)
RRM3_PUB1 341..414 CDD:410033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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