Protein Alignment SYNCRIP and Syp

DIOPT Version :10

• Sequence 1: NP_006363.4
• Gene: SYNCRIP / 10492
• HGNCID: 16918
• Length: 623
• Species: Homo sapiens
• Sequence 2: NP_001262777.1
• Gene: Syp / 42460
• FlyBaseID: FBgn0038826
• Length: 761
• Species: Drosophila melanogaster
• Alignment Length: 737
• Identity: 330/737 - (44%)
• Similarity: 412/737 - (55%)
• Gaps: 151/737 - (20%)

Human     8 GNG-----TEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKE 67
            |||     ..:..|.......:|::..||:.||.:|||.||||||..|.:||::|||||::||||
  Fly    46 GNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALKE 110

Human    68 FNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREK---QGTKVADSSKGPDEAKIKALLE 129
            |..||||.||.||.:|:|.||.||||:||||||||||:.:   ||.....:.|||||.|||.:||
  Fly   111 FPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILE 175

Human   130 RTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLM 194
            ||||||||||||||||||||.  :.|..|..|.|:|.||||:|::||||:||||..|.|||||||
  Fly   176 RTGYTLDVTTGQRKYGGPPPH--WEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLM 238

Human   195 MDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQI 259
            |||:||.|||||||||..:|||..||:..|:.|||:||.|||.||..|:|||||:|||::.::::
  Fly   239 MDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRTGKKIGVTISFNNHRLFVGNIPKNRDRDEL 303

Human   260 LEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWAD 324
            :|||||...||.:||:|..||||||||||||||||.||.|:.|:|||.:|::||||....|:|||
  Fly   304 IEEFSKHAPGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWAD 368

Human   325 PIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAME 389
            |.|:||.:.|:|||||:||||...|:|:.|::.|.|:||:|||||:||||||||::||.||:||.
  Fly   369 PQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAMR 433

Human   390 EMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQM--------------YDDYYYYGPPH-- 438
            .:|||::...|||:..||||..|:|:.:..|...:..|              ...|....|.|
  Fly   434 GLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGFETLSPYRNLSPTHPS 498

Human   439 ------MPPPTRGRGRGGRGGYGYP-PDYYGYEDYYDYYGYDYHNYRGG---------YEDPY-- 485
                  |.|       |.|.....| |..|.|  :||::|:.  :||.|         |:|.|
  Fly   499 IMSLTPMRP-------GARMPLRTPIPREYDY--FYDFFGFS--DYRQGGSFGNNVSYYDDMYRW 552

Human   486 ----YGYEDFQVGARGRGG----------------------------RGARG------AAPS--- 509
                |.|.|:..|..|..|                            |.|||      |:||
  Fly   553 IDGDYNYYDYPNGGGGGSGGGGGSVSGGTVLPLSAGGSQNSPMASGQRSARGSASGPSASPSLMG 617

Human   510 --RGRGAAPPRGRAGYSQRGG-----------PGSARGVRGARGGAQQQRGRGVRGARGGRGGNV 561
              ||.|...||||. ..|||.           ...|....|....|..|||...:||....||..
  Fly   618 VGRGHGITVPRGRV-VGQRGSISRLGAQTVPQAAGAAAAAGQAAAAVAQRGATGQGAPAATGGFR 681

Human   562 G-----------------------GKRKADG--YNQPDSKRRQT-----NNQNWGSQPIAQQPLQ 596
            |                       ||||.||  .|..|.|||..     |..:|||.|:.||||
  Fly   682 GVLPTRPSARGTQHVKPLQNLPVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLPLPQQPL- 745

Human   597 GGDHSGNYGYKSENQEFYQDTF 618
                 |..|     :::|.|||
  Fly   746 -----GTNG-----EQWYMDTF 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SYNCRIP	NP_006363.4	NURR_hnRNPQ	23..107	CDD:410954	53/83 (64%)
		hnRNP-R-Q	103..615	CDD:273732	271/632 (43%)
		Interaction with APOBEC1	400..561		64/248 (26%)
		8 X 3 AA repeats of R-G-G	448..559		46/176 (26%)
		3 X 4 AA repeats of Y-Y-G-Y	460..488		12/42 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..623		56/202 (28%)
		Interaction with SMN. /evidence=ECO:0000269|PubMed:11574476	518..549		12/41 (29%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	564..578		8/15 (53%)
Syp	NP_001262777.1	NURR_Syncrip-like	68..150	CDD:410953	53/81 (65%)
		hnRNP-R-Q	153..>563	CDD:273732	216/422 (51%)