Protein Alignment SYNCRIP and Sxl

DIOPT Version :10

• Sequence 1: NP_006363.4
• Gene: SYNCRIP / 10492
• HGNCID: 16918
• Length: 623
• Species: Homo sapiens
• Sequence 2: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 84/459 - (18%)
• Similarity: 146/459 - (31%)
• Gaps: 158/459 - (34%)

Human    72 ERGTVTYKSKFLQS--DTYKANSAGGRIVISEFGTLALPDPCKSIFERFMSRFEPPTMTDNTNVN 134
            :||.:..|...|||  |.::..|..|:.::.....|......:.:::....|.|..
  Fly    36 QRGGMETKMVELQSRLDQFQMQSESGQTIVELTEQLEKAKADRVLWDEERQRMEAA--------- 91

Human   135 FVQYKGDYYMSTETNFMNKVDIEMLERTEKV-------DWSKFIAVNGATAHPHYDPDGTAYNMG 192
                     ::||.:..|.:|.||....|::       :.|.|  ....:...:.|.|..:....
  Fly    92 ---------LNTERSARNALDAEMAAMREQLMKNVDLFESSTF--QKRPSQKKNRDDDSCSRTTS 145

Human   193 NSYGPRGSCYNIIRVPPKKKEPGETIHGAQ---------VLCSIAST-------EKMKPSYYHSF 241
            |.....||.            ..|||:|..         :|.::|||       ..::....|..
  Fly   146 NLSQLTGSF------------TAETINGVHSTSRGSPEVLLDNMASTFEQLRMINDLRQRNEHCQ 198

Human   242 GMTKNYIIFVEQPVKMKLWKIITSKIRGKPFADGISWEPQYNTRFHVVDKHTGQLLPGMYYSMPF 306
            ..|:.....:|.                             :|....:||.|.           .
  Fly   199 RETERMKAIIEA-----------------------------STLIETLDKKTS-----------L 223

Human   307 LTYHQINAFEDQGCI------VIDLCCQDDGRSLDLYQLQNLRKAGEGL-DQVYELK---AKSFP 361
            ..:..|...|.:|..      :..|...::|.:..::  :.:.:..|.| ::..||:   :..|.
  Fly   224 KAFESIRVGELEGAYNRLKNDMERLVSGENGATHSVF--ERIMEENERLREEAVELRSMLSSHFE 286

Human   362 RRFVLPLDVSVDAAEGKNLSPLSYSS-ASAVKQGDGEIWCSPENLHHEDLEEEGGIEFPQINYGR 425
            ::       ||..:.|...||...|. .|.....||.        ...||||:..||
  Fly   287 KQ-------SVAGSSGYRRSPRPDSGHCSGADSEDGS--------SGADLEEDLCIE-------- 328

Human   426 FNGKKYSFFYGCGFRHL--VGDSLIKVDVTNKTL---RVWREEGFYPSEPVFVP--------VPG 477
                     ..|  |||  :.::|.|: :||:.|   |:.::..|..|:.||.|        |.|
  Fly   329 ---------RQC--RHLKNLAENLTKM-LTNQNLEIERLQQQLRFSESQTVFRPSDCSLDEAVRG 381

Human   478 ADEE 481
            |.::
  Fly   382 AHKQ 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SYNCRIP	NP_006363.4	NURR_hnRNPQ	23..107	CDD:410954	10/36 (28%)
		hnRNP-R-Q	103..615	CDD:273732	75/426 (18%)
		Interaction with APOBEC1	400..561		24/95 (25%)
		8 X 3 AA repeats of R-G-G	448..559		13/45 (29%)
		3 X 4 AA repeats of Y-Y-G-Y	460..488		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..623
		Interaction with SMN. /evidence=ECO:0000269|PubMed:11574476	518..549
		Bipartite nuclear localization signal. /evidence=ECO:0000255	564..578
Sxl	NP_001259303.1	sex-lethal	16..297	CDD:273740	54/341 (16%)