Protein Alignment CREB3 and CrebB

DIOPT Version :10

• Sequence 1: NP_006359.3
• Gene: CREB3 / 10488
• HGNCID: 2347
• Length: 371
• Species: Homo sapiens
• Sequence 2: NP_001334685.1
• Gene: CrebB / 32817
• FlyBaseID: FBgn0265784
• Length: 331
• Species: Drosophila melanogaster
• Alignment Length: 195
• Identity: 43/195 - (22%)
• Similarity: 74/195 - (37%)
• Gaps: 60/195 - (30%)

Human    65 NILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTD----- 124
            |.:..:.||.:..:.....|.::      .||...:.:|   .|..||..:.....:.|:
  Fly   159 NKIPPTFPCKIKPEPNTQHPEDS------DESLSDDDSQ---HHRSELTRRPSYNKIFTEISGPD 214

Human   125 -EEKSLLEKEGLI--------------------LPETLPLTK-----------TEEQILKRVRRK 157
             ...||...:|::                    |..|..|:.           .|:|..||..|.
  Fly   215 MSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREIRL 279

Human   158 IRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISN 222
            .:|:.:|:|.|||||.|:..||              |:|.:||.||.:|:::|:.|:.:..:..|
  Fly   280 QKNREAARECRRKKKEYIKCLE--------------NRVAVLENQNKALIEELKSLKELYCQTKN 330

Human   223  222
              Fly   331  330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREB3	NP_006359.3	Transcription activation (acidic). /evidence=ECO:0000269|PubMed:10984507	1..92		4/26 (15%)
		LXXLL motif 1	13..17
		LXXLL motif 2	54..58
		HCFC1-binding-motif (HBM)	78..81		0/2 (0%)
		bZIP_CREB3	151..211	CDD:269837	21/59 (36%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	152..184		14/31 (45%)
		coiled coil	153..204	CDD:269837	18/50 (36%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	192..213		8/20 (40%)
CrebB	NP_001334685.1	pKID	<191..>214	CDD:396650	5/25 (20%)
		bZIP_CREB1	274..327	CDD:269838	23/66 (35%)
		coiled coil	275..327	CDD:269838	22/65 (34%)