DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAP1 and capt

DIOPT Version :9

Sequence 1:	NP_001099000.2	Gene:	CAP1 / 10487	HGNCID:	20040	Length:	475	Species:	Homo sapiens
Sequence 2:	NP_001033870.1	Gene:	capt / 45233	FlyBaseID:	FBgn0261458	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	233/507 - (45%)
Similarity:	316/507 - (62%)	Gaps:	56/507 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     4 MQNLVERLERAVGRLEAV--------SHTSDMHRGYADS----------------PSKAGAAPYV 44
            ::::.||||..|.|||..        ..|..:....|:.                ||...:...|
  Fly   298 LESICERLETLVDRLERTLTAPQPIELPTPTLPPPPAEEEEALPVFEKAETPPPPPSPPSSNMSV 362

Human    45 QAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAENKLSDLLAPIS 109
            ..|:.::|||:::||.:|.:|||||.:|||:|.:....:...:..|:|..|||:.|.::||.|.|
  Fly   363 AGFEDIVAGPLSQYLTLSAKIGGDVAQHAELVKSAFGSQLQYVTLATQIAQPAQPKQAELLKPTS 427

Human   110 EQIKEVITFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKD 174
            .||..:..||||:|.|..||||||:||||.|||||.:...|||||||||||..|||||||||:|:
  Fly   428 TQISAIQDFREKHRSSPFFNHLSAISESIPALGWVCVEKTPGPYVKEMNDAGQFYTNRVLKEWKE 492

Human   175 VDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSAGSCPPPPPP--CP 237
            .|..||:|.:|::...|||||||:::|||||.||..|          :.| ||..||||||  .|
  Fly   493 KDVTHVEWARAWVQTLTELQAYIRQYHTTGLVWSGKG----------AAP-AGGAPPPPPPGGLP 546

Human   238 PPPPVSTISC-SYESA--SRSSLFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKP 299
            ||||:..:|. ..:||  .||:||||||||..||..||.|:.||:|||||:|       |:||.|
  Fly   547 PPPPMLDLSALKLDSAGDDRSALFAQINQGADITKGLKKVTGDMQTHKNPSL-------RTGPAP 604

Human   300 FSAP------KPQTSPSPKRATKKEPAVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVN 358
            |.:|      |...:||..:|  |.| |.|.:||||.:|.|:|.:.|::|:.|:..|.|::||..
  Fly   605 FKSPAQSGGSKAVAAPSAAQA--KAP-VFERDGKKWIIEYQKNNTGLLVENAEMNNVVYVFKCEG 666

Human   359 TTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHAYLSKN 423
            :||.:|||:|:|..|:|||..|:||.||..||.:|.:.|::||:|.|||:||:|||||..||||:
  Fly   667 STLTVKGKVNNIVFDSCKKCSLLFDSVVASVEFVNCQSVQMQVLGSVPTVSIDKTDGCQMYLSKD 731

Human   424 SLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG 475
            ||..|||::||||||:|:|.:.||:.|..:|||:||...|:.|.|...:..|
  Fly   732 SLGVEIVNSKSSEMNILLPDDSGDYTELALPEQYKTTIAGKTLKTVCVDSLG 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAP1	NP_001099000.2	CAP_N	5..62	CDD:395969	19/80 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..237		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..319		18/46 (39%)
		CAP_C	319..473	CDD:400772	78/153 (51%)
capt	NP_001033870.1	CAP_N	299..604	CDD:279545	146/322 (45%)
		CAP_C	633..781	CDD:285769	75/147 (51%)
		CARP	664..701	CDD:197827	19/36 (53%)
		CARP	702..739	CDD:197827	22/36 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157045
Domainoid	1	1.000	256	1.000	Domainoid score	I2044
eggNOG	1	0.900	-	-		E1_KOG2675
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74572
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1748
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1098760at2759
OrthoFinder	1	1.000	-	-		FOG0001959
OrthoInspector	1	1.000	-	-		otm42204
orthoMCL	1	0.900	-	-		OOG6_101374
Panther	1	1.100	-	-	O	PTHR10652
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R167
SonicParanoid	1	1.000	-	-		X1462
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790