DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NXF1 and sbr

DIOPT Version :9

Sequence 1:NP_006353.2 Gene:NXF1 / 10482 HGNCID:8071 Length:619 Species:Homo sapiens
Sequence 2:NP_524660.1 Gene:sbr / 43944 FlyBaseID:FBgn0003321 Length:672 Species:Drosophila melanogaster


Alignment Length:703 Identity:220/703 - (31%)
Similarity:338/703 - (48%) Gaps:139/703 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    23 KKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVAMSDAQ-----DGPRVRYNP-------- 74
            |:|.|..: :|   |...|.||....:   .||..|..:.|.|     :..||.:.|        
  Fly     3 KRGGGSSQ-RY---NNNVGNGGGRYNA---PEDFDDFDVEDRQRRKDRNKRRVSFKPSQCLHNKK 60

Human    75 -YTTRPN--RRGDTWHD--------RDRIHVTVRRDRAPPERGGAGTSQDGTSKNWFKITIPYGR 128
             ...||.  ||.|...|        :||  .|.||..:|..||..|.... .|..|:::|:...:
  Fly    61 DIKLRPEDLRRWDEDDDMSDMTTAVKDR--PTSRRRGSPIPRGKFGKLMP-NSFGWYQVTLQNAQ 122

Human   129 KYDKAWLLSMIQSKCSVP--FTPIEFHYENTRAQFFVEDASTASALKAV--------NYKILDRE 183
            .|:|..|||.:.:..| |  |.|..:..|.....||.:|...|..::.:        .|:::.| 
  Fly   123 IYEKETLLSALLAAMS-PHVFIPQYWRVERNCVIFFTDDYEAAERIQHLGKNGHLPDGYRLMPR- 185

Human   184 NRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLN 248
                   :.|..|...|.:..|    |::|:.|:|||:...:||||....:||||  :.:...|.
  Fly   186 -------VRSGIPLVAIDDAFK----EKMKVTMAKRYNIQTKALDLSRFHADPDL--KQVFCPLF 237

Human   249 RRSCMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIK 313
            |::.|.|.:.|:.:|||:|.:|||::|.:..::....:.::.||||||.|..|::.|...|..::
  Fly   238 RQNVMGAAIDIMCDNIPDLEALNLNDNSISSMEAFKGVEKRLPNLKILYLGDNKIPSLAHLVVLR 302

Human   314 GLKLEELWLDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYF 378
            .|.:.||.|..|.....::|...:||.:|.:||||::|||..|.|.|.||:.....|...|.||.
  Fly   303 NLSILELVLKNNPCRSRYKDSQQFISEVRRKFPKLVKLDGETLEPQITFDLSEQGRLLETKASYL 367

Human   379 ----GTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSIPFIPQNPARSSLAEYFKDS 439
                |.|    :|..||.||:.|:|||:||.||||||:.|..|:|:|...|   ...|..::|.:
  Fly   368 CDVAGAE----VVRQFLDQYFRIFDSGNRQALLDAYHEKAMLSISMPSASQ---AGRLNSFWKFN 425

Human   440 RNVKK-LKDPTLRFRLLKHTRLNVVAFLNELPKTQHDVNSFVVDISAQTSTLLCFSVNGVFKEVD 503
            ||::: |.....|.|.||:.||..|:.|:|.||||||..:|.||::...::::.|:|.|:|||::
  Fly   426 RNLRRLLNGEENRTRNLKYGRLACVSTLDEWPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFKELN 490

Human   504 GKSRD-------SLRAFTRTFIAVPASNSGLCIVNDELFVRNASSE---EIQRAFAMPAP--TPS 556
            .::.:       .:|.|.||::.|| .|:|.||.|:.:|:.||:.|   |.:|:...|||  .||
  Fly   491 DETNNPASMELYDVRHFARTYVVVP-QNNGFCIRNETIFITNATHEQVREFKRSQHQPAPGAMPS 554

Human   557 SS--------------------------PVPTLSPE----------------------------- 566
            :|                          ||..||.:                             
  Fly   555 TSSAVTSPQAGAAAGLQGRLNALGVATGPVAILSGDPLAATAPVNSGSAAISTTAVAPGAQDEST 619

Human   567 QQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFMK 619
            :.:|::|.|.||.||:.||:|||::.|||:..:|..|..|..:.:||..||||
  Fly   620 KMQMIEAMSAQSQMNVIWSRKCLEETNWDFNHAAFVFEKLFKENKIPPEAFMK 672

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NXF1NP_006353.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..85 20/77 (26%)
RNA-binding (RBD) 2..118 32/118 (27%)
Minor non-specific RNA-binding 2..60 11/36 (31%)
Major non-specific RNA-binding 61..118 21/80 (26%)
Nuclear localization signal 67..100 14/51 (27%)
Nuclear export signal 83..110 10/34 (29%)
Tap-RNA_bind 116..198 CDD:401194 21/91 (23%)
noncanonical RNP-type RNA-binding (RBD) domain 121..198 19/86 (22%)
leucine-rich repeat (LRR) domains 199..371 60/171 (35%)
LRR <200..>327 CDD:227223 44/126 (35%)
leucine-rich repeat 224..266 CDD:275382 15/41 (37%)
LRR_8 265..327 CDD:404697 21/61 (34%)
leucine-rich repeat 267..292 CDD:275382 5/24 (21%)
leucine-rich repeat 293..316 CDD:275382 8/22 (36%)
leucine-rich repeat 317..347 CDD:275382 9/29 (31%)
NTF2 382..538 CDD:238403 63/163 (39%)
TAP_C 556..618 CDD:197882 27/116 (23%)
sbrNP_524660.1 Tap-RNA_bind 112..191 CDD:286271 19/87 (22%)
leucine-rich repeat 215..255 CDD:275382 15/41 (37%)
LRR_RI <223..341 CDD:238064 40/119 (34%)
LRR_8 256..315 CDD:290566 19/58 (33%)
LRR_4 256..298 CDD:289563 14/41 (34%)
leucine-rich repeat 256..281 CDD:275382 5/24 (21%)
leucine-rich repeat 282..305 CDD:275382 8/22 (36%)
leucine-rich repeat 306..336 CDD:275382 9/29 (31%)
NTF2 372..531 CDD:238403 65/166 (39%)
Big_3_5 <578..>614 CDD:293246 4/35 (11%)
TAP_C 609..671 CDD:197882 21/61 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 114 1.000 Domainoid score I6066
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H38176
Inparanoid 1 1.050 277 1.000 Inparanoid score I2942
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1051093at2759
OrthoFinder 1 1.000 - - FOG0000862
OrthoInspector 1 1.000 - - otm41330
orthoMCL 1 0.900 - - OOG6_102057
Panther 1 1.100 - - LDO PTHR10662
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R710
SonicParanoid 1 1.000 - - X1267
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.960

Return to query results.
Submit another query.