Protein Alignment HOXB13 and C15

DIOPT Version :10

• Sequence 1: NP_006352.2
• Gene: HOXB13 / 10481
• HGNCID: 5112
• Length: 284
• Species: Homo sapiens
• Sequence 2: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Alignment Length: 191
• Identity: 39/191 - (20%)
• Similarity: 69/191 - (36%)
• Gaps: 56/191 - (29%)

Human   108 AYPAETPTAGEEYPSRPTEFAF---YPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSY 169
            ||...|..|...|.|....:::   ||...|.:             .|..|  |:...|
  Fly   131 AYKLATSIANSTYGSAAALYSYPHLYPSAAGGH-------------VLRVP--PQRTPL------ 174

Human   170 QSWALAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQ--------------HPPDACAFRRGRKKR 220
             :|||.                 |...||.|..:.:              ||.......:.:|.|
  Fly   175 -TWALP-----------------PLHHAALAHQAVKDRLAAAFPIARRIGHPYQNRTPPKRKKPR 221

Human   221 IPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKNS 281
            ..:::.|:.|||:.:...|::...:|..::....:::.|:..||||||.|.::..|:.:.:
  Fly   222 TSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREA 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB13	NP_006352.2	HoxA13_N	12..123	CDD:463521	5/14 (36%)
		Homeodomain	217..273	CDD:459649	16/55 (29%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	217..246		7/28 (25%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	258..269		6/10 (60%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	270..273		1/2 (50%)
C15	NP_476873.2	COG5576	<196..315	CDD:227863	19/87 (22%)
		Homeodomain	218..274	CDD:459649	16/55 (29%)