Protein Alignment HOXB13 and lbe

DIOPT Version :10

• Sequence 1: NP_006352.2
• Gene: HOXB13 / 10481
• HGNCID: 5112
• Length: 284
• Species: Homo sapiens
• Sequence 2: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Alignment Length: 330
• Identity: 71/330 - (21%)
• Similarity: 112/330 - (33%)
• Gaps: 99/330 - (30%)

Human    32 PLTSHPAAPTLMP--------------AVNYAPLDLPGSAEPPKQ--CHPCPGVPQGTSPAPVPY 80
            |....|:.|:.:|              ..:::..|:.|.:|..::  ..|.|.......||..|.
  Fly   104 PRDHTPSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPPPNANLLAPPASRPI 168

Human    81 GYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTA----------GEEYPSRPTEFAFYPGYPG 135
            .. .||....|.....:.|.|.||.|      .|:.          |...|.||    |.|....
  Fly   169 AP-SGGLLQPRTEPLDVHPAAAAAML------LPSGQIVRPWDHLLGPTMPVRP----FIPSALL 222

Human   136 TY-QPMASYLDVSVVQTLGAPGE-PRHDSLLPV-------DSYQSWALAGGWNSQMCC------- 184
            .| |.:|......:.:...|..: .||..:.|.       .|.:|...:....|..||
  Fly   223 HYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEK 287

Human   185 ----------------QGEQNPPGPFWKAAFADSSGQHPPDAC------------------AF-- 213
                            :.|:.|.|.      ..|:|..|.||.                  .|
  Fly   288 LEKLTTQEGSEEAQKKKSEEQPTGS------GKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSN 346

Human   214 ----RRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKV 274
                ::.||.|..::..|:.|||:.:...|:::...|.:|:|:..||..|:..||||||.|:|:.
  Fly   347 RPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRD 411

Human   275 LAKVK 279
            :.::|
  Fly   412 IEELK 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB13	NP_006352.2	HoxA13_N	12..123	CDD:463521	23/116 (20%)
		Homeodomain	217..273	CDD:459649	21/55 (38%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	217..246		8/28 (29%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	258..269		6/10 (60%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	270..273		1/2 (50%)
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	21/55 (38%)