Protein Alignment HOXB13 and NK7.1

DIOPT Version :10

• Sequence 1: NP_006352.2
• Gene: HOXB13 / 10481
• HGNCID: 5112
• Length: 284
• Species: Homo sapiens
• Sequence 2: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 271
• Identity: 66/271 - (24%)
• Similarity: 98/271 - (36%)
• Gaps: 66/271 - (24%)

Human     8 TLDGAKDIEGLLGAGGGRNLVAHSPLTSHPA-APTLMPAVNYAPLDLPGSAEPPKQCHPCPGVPQ 71
            ::..|.:.|....||      |.|..|:..| |.|:..|....|||.|.:....|:.......|.
  Fly   241 SMSDASEEESAAVAG------ATSAATAAAAVAATITAATVATPLDQPLNLCVVKKSRDSNNSPM 299

Human    72 GTSPAPVPYGYFGGGYYSCRVSRSSLKPCAQ----AATLAAYPAETPTAGEEYPSRPTEFAFYPG 132
               ||.......|   .|.....||.||.|:    ::|:|..|..:||...:...|
  Fly   300 ---PATKQSQILG---KSATKKESSGKPAAKKKKLSSTVALPPDISPTGSSDSLMR--------- 349

Human   133 YPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNSQMCCQGEQNPPGPFWKA 197
                        |..:.....:||                   ...|:||  |...|..    ..
  Fly   350 ------------DKLMANNSSSPG-------------------SNVNAQM--QSNANST----LE 377

Human   198 AFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITI 262
            ...|.|.....||   ||.:|.|..::..|:.|||:.:...|:::..:|.:::....::|.|:.|
  Fly   378 TTEDDSDSGSTDA---RRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKI 439

Human   263 WFQNRRVKEKK 273
            ||||||.|.||
  Fly   440 WFQNRRTKWKK 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB13	NP_006352.2	HoxA13_N	12..123	CDD:463521	31/115 (27%)
		Homeodomain	217..273	CDD:459649	18/55 (33%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	217..246		7/28 (25%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	258..269		7/10 (70%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	270..273		1/2 (50%)
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	18/55 (33%)