Protein Alignment HOXB13 and ems

DIOPT Version :10

• Sequence 1: NP_006352.2
• Gene: HOXB13 / 10481
• HGNCID: 5112
• Length: 284
• Species: Homo sapiens
• Sequence 2: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Alignment Length: 283
• Identity: 73/283 - (25%)
• Similarity: 106/283 - (37%)
• Gaps: 84/283 - (29%)

Human    31 SPLTSHP-AAPTLM---------------PAVNYAPLDL--PGSAEPPKQCHPCPGV-------- 69
            ||.:|.| ::|||:               |..||....:  ||.|.|...    ||:
  Fly   209 SPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMMHPGGAGPMMM----PGMPPAGLVRP 269

Human    70 -PQGTSPAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTAGEEYPSRPTEF----AF 129
             |.|....|:|.|..|      .....:|.|...|      |.|.|.....:.....:|    |.
  Fly   270 FPMGPGGPPMPQGQPG------LPDIKALPPYINA------PPELPPQHNPHLIAAAQFQMAAAL 322

Human   130 YPGY---PGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQ--SWALAGGWNSQMCCQGEQN 189
            ..|:   |......|:.|.....|.:..||..|       ||||  .|.|:.        .|...
  Fly   323 QAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMAR-------DSYQLYPWLLSR--------HGRIF 372

Human   190 P---PGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISA 251
            |   ||.|..          ||    ||:.::.|..:|..||.:||..:.:|:::...:|:.::.
  Fly   373 PHRFPGSFLV----------PP----FRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQ 423

Human   252 ATSLSERQITIWFQNRRVKEKKV 274
            ..:|||.|:.:||||||.|.|::
  Fly   424 NLNLSETQVKVWFQNRRTKHKRM 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB13	NP_006352.2	HoxA13_N	12..123	CDD:463521	28/118 (24%)
		Homeodomain	217..273	CDD:459649	19/55 (35%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	217..246		7/28 (25%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	258..269		6/10 (60%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	270..273		1/2 (50%)
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	19/55 (35%)