DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXB13 and Scr

DIOPT Version :10

Sequence 1:NP_006352.2 Gene:HOXB13 / 10481 HGNCID:5112 Length:284 Species:Homo sapiens
Sequence 2:NP_001368995.1 Gene:Scr / 40833 FlyBaseID:FBgn0003339 Length:564 Species:Drosophila melanogaster


Alignment Length:360 Identity:87/360 - (24%)
Similarity:125/360 - (34%) Gaps:129/360 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    20 GAG--------GGRNLVAHSPLTSHPAAPTLMP-AVNYAPLDLPGSAEPPKQCHPCPGVPQGTSP 75
            |||        ||.|....|...:.|.|....| |..|.|             :..|..||....
  Fly    45 GAGGSGGVVPSGGTNGGQGSAGAATPGANDYFPAAAAYTP-------------NLYPNTPQAHYA 96

Human    76 APVPYGYFGG----GYYSCRVSRSSL--------KPCAQAATLAAYPAETPTAGEEYPSRPTE-- 126
            ....||..|.    .|...:..|..|        :..|.||...|...:...|.:::|.:..:  
  Fly    97 NQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQHPQQQQQQQ 161

Human   127 -------FAFYPGYPG----------------------TYQPMASYLDV------------SVVQ 150
                   :|..|..||                      ..|.:||..|:            |||:
  Fly   162 QANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVE 226

Human   151 TL--------------------------------GAPGE---PRH-----DSLLPVDSYQSWALA 175
            ::                                |.||.   |.|     ||....||...   |
  Fly   227 SVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNE---A 288

Human   176 GGWNSQMCCQGEQNPPG--PFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAAN 238
            |  :||....|::|||.  |:.|.....:|..:     |....:::|..|::.|..|||:|:..|
  Fly   289 G--SSQNSGNGKKNPPQIYPWMKRVHLGTSTVN-----ANGETKRQRTSYTRYQTLELEKEFHFN 346

Human   239 KFITKDKRRKISAATSLSERQITIWFQNRRVKEKK 273
            :::|:.:|.:|:.|..|:||||.|||||||:|.||
  Fly   347 RYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKK 381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXB13NP_006352.2 HoxA13_N 12..123 CDD:463521 28/123 (23%)
Homeodomain 217..273 CDD:459649 25/55 (45%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8 217..246 9/28 (32%)
Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536 258..269 9/10 (90%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8 270..273 1/2 (50%)
ScrNP_001368995.1 Homeodomain 325..381 CDD:459649 25/55 (45%)

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