Protein Alignment HOXB13 and zen

DIOPT Version :10

• Sequence 1: NP_006352.2
• Gene: HOXB13 / 10481
• HGNCID: 5112
• Length: 284
• Species: Homo sapiens
• Sequence 2: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 177
• Identity: 47/177 - (26%)
• Similarity: 66/177 - (37%)
• Gaps: 49/177 - (27%)

Human   109 YPAETPTAGEEYPSRPTEFAFYP------------GYPGTYQPMASYLDVSVVQTLGAPGEPRHD 161
            ||......| .|.:.|:|..:..            |.|..|..|.|.     ..||.....|:|.
  Fly     8 YPVHQAKVG-SYSADPSEVKYSDLIYGHHHDVNPIGLPPNYNQMNSN-----PTTLNDHCSPQHV 66

Human   162 SLLPVDSYQSWALAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKG 226
            ....|.|                  ::|.|          |...|.......:|   .|..::..
  Fly    67 HQQHVSS------------------DENLP----------SQPNHDSQRVKLKR---SRTAFTSV 100

Human   227 QLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKK 273
            ||.|||.|:.:|.::.:.:|.:|:...||.|||:.|||||||:|.||
  Fly   101 QLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKK 147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB13	NP_006352.2	HoxA13_N	12..123	CDD:463521	4/13 (31%)
		Homeodomain	217..273	CDD:459649	23/55 (42%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	217..246		8/28 (29%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	258..269		8/10 (80%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	270..273		1/2 (50%)
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	24/58 (41%)