DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXB13 and exex

DIOPT Version :10

Sequence 1:NP_006352.2 Gene:HOXB13 / 10481 HGNCID:5112 Length:284 Species:Homo sapiens
Sequence 2:NP_648164.1 Gene:exex / 38884 FlyBaseID:FBgn0041156 Length:525 Species:Drosophila melanogaster


Alignment Length:450 Identity:91/450 - (20%)
Similarity:126/450 - (28%) Gaps:213/450 - (47%)


- Green bases have known domain annotations that are detailed below.


Human    29 AHSPLTSHPAAPTLMPAVNYAPLDLPGSAEPPKQCH------------PCP---GVPQGTSPAPV 78
            |.||  :|.||.|..|...|.|...||.|:...|..            |.|   |.|....|.|.
  Fly    76 AASP--THSAATTGSPVSTYTPALSPGGAQDSSQTESGQSSQMPLLVAPMPVGTGPPHSHPPPPH 138

Human    79 PYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTAGEEYPSRPTEFAFYPGYPG-------- 135
            |..|..|......|      |....| |..||  .|......|:.|      ||.|.        
  Fly   139 PRLYVEGFPPPHHV------PHPHPA-LGTYP--LPRLPLMLPANP------PGVPSGAAAPPPV 188

Human   136 TYQPMASYLDVS----VVQTLGAP--GEPRH----DSLLPVDSYQSW------------------ 172
            :.||.|::|..|    ...||..|  .:|:.    |:||....:||.                  
  Fly   189 SPQPAANHLSHSGATMATTTLLPPAQSQPKKSFCIDALLAKSQHQSGEPQPIIVDDRLAALHYAR 253

Human   173 -----------------------ALAGGWNSQMC------------------------------- 183
                                   :.|||.:.|..                               
  Fly   254 DQAELNHAFVTASNAAAAAQAAASAAGGISEQEALQRIRDSREYDSPSPDGMSRSESPTSSHRSS 318

Human   184 ------CQGEQNPPG--------------------------PFWKAAFADSSGQHP--------- 207
                  |:.:|.|.|                          |.....|...:|.||         
  Fly   319 PPISPGCEDQQQPHGALHPQHLSMRMSDFHDEFKKPIPPHSPIRPQDFPLYAGGHPYQLLAQGGS 383

Human   208 -----------------------------------------PDACAF------RRGRKKRIPYSK 225
                                                     |:..|:      .:.|:.|..::.
  Fly   384 AFHRPLDPSGKPIPIPMGHNFMPSQLQFEFLARAGMLHHRIPELAAYPHHAILGKTRRPRTAFTS 448

Human   226 GQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVK---EKKVLAKVKNSA 282
            .||.|||:::..||::::.||.::::...|||.|:.|||||||:|   .||...:.|..|
  Fly   449 QQLLELEKQFKQNKYLSRPKRFEVASGLMLSETQVKIWFQNRRMKWKRSKKAQQEAKERA 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXB13NP_006352.2 HoxA13_N 12..123 CDD:463521 31/108 (29%)
Homeodomain 217..273 CDD:459649 23/58 (40%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8 217..246 9/28 (32%)
Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536 258..269 7/10 (70%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8 270..273 1/5 (20%)
exexNP_648164.1 Homeodomain 440..496 CDD:459649 23/55 (42%)

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