Protein Alignment HOXB13 and en

DIOPT Version :10

• Sequence 1: NP_006352.2
• Gene: HOXB13 / 10481
• HGNCID: 5112
• Length: 284
• Species: Homo sapiens
• Sequence 2: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 266
• Identity: 62/266 - (23%)
• Similarity: 92/266 - (34%)
• Gaps: 92/266 - (34%)

Human    37 PAAPTLMPAVNYAPLDLPGS--AEPPKQCHPCPGVPQGTSPAPVPYGYFGGGYYSCRVSRSSLKP 99
            |||||:    ...||....|  |.||    |.......:|.:.|           ...|.||...
  Fly   309 PAAPTM----TQPPLSSSASSLASPP----PASNASTISSTSSV-----------ATSSSSSSSG 354

Human   100 CAQAATLAAYPAETPTAGEEYPSRPTEFAFYPGYPGTYQPMASYLDVSVVQTLGAPG-------- 156
            |:.|                                     ||.|:.|....|||.|
  Fly   355 CSSA-------------------------------------ASSLNSSPSSRLGASGSGVNASSP 382

Human   157 EPRHDSLLPVDSYQSWALAGGWNS---------QMCCQGEQNPPGPFWKAAFADSSGQHPPDACA 212
            :|:     |:....:.:...|..|         ....:|.:|...|.|  .:.......|.....
  Fly   383 QPQ-----PIPPPSAVSRDSGMESSDDTRSETGSTTTEGGKNEMWPAW--VYCTRYSDRPSSGPR 440

Human   213 FRR----------GRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNR 267
            :||          .::.|..:|..||..|:||:..|:::|:.:|:::|:...|:|.||.|||||:
  Fly   441 YRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNK 505

Human   268 RVKEKK 273
            |.|.||
  Fly   506 RAKIKK 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB13	NP_006352.2	HoxA13_N	12..123	CDD:463521	19/87 (22%)
		Homeodomain	217..273	CDD:459649	22/55 (40%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	217..246		9/28 (32%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	258..269		7/10 (70%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	270..273		1/2 (50%)
en	NP_523700.2	Homeodomain	455..511	CDD:459649	22/55 (40%)
		Engrail_1_C_sig	512..542	CDD:431338	62/266 (23%)