DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment UBE2E3 and Ubc2

DIOPT Version :9

Sequence 1:	NP_001265483.1	Gene:	UBE2E3 / 10477	HGNCID:	12479	Length:	207	Species:	Homo sapiens
Sequence 2:	NP_001260362.1	Gene:	Ubc2 / 34487	FlyBaseID:	FBgn0015320	Length:	232	Species:	Drosophila melanogaster

Alignment Length:	236	Identity:	156/236 - (66%)
Similarity:	170/236 - (72%)	Gaps:	33/236 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSDRQRSDDESPSTSSGSSDADQRDPAAPE-----------------PEEQEERKPSAT----- 43
            |||..........:|||.:|:|    |:||.                 |:.:..|..:|.
  Fly     1 MSSTPAAGSAAEVATSSATSNA----PSAPSTTASNVSNTSQPTTAGTPQARGGRGSNANGGASG 61

Human    44 -------QQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPP 101
                   :.:|..|.:.:.:..|.|||||||||||||||||||||||||||||:|||.|||||||
  Fly    62 SNAGGGDEPRKEAKTTPRISRALGTSAKRIQKELAEITLDPPPNCSAGPKGDNLYEWVSTILGPP 126

Human   102 GSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSI 166
            |||||||||||||.||.:|||||||||||||||||||||||||||||||||||||||||||||||
  Fly   127 GSVYEGGVFFLDIHFSPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSI 191

Human   167 CSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT 207
            ||||||||||||||||||||||.||.|||||||.|||||||
  Fly   192 CSLLTDCNPADPLVGSIATQYLQNREEHDRIARLWTKRYAT 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UBE2E3	NP_001265483.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		18/90 (20%)
UBE2E3	NP_001265483.1	UQ_con	65..202	CDD:395127	128/136 (94%)
Ubc2	NP_001260362.1	COG5078	86..231	CDD:227410	136/144 (94%)
Ubc2	NP_001260362.1	UQ_con	90..227	CDD:278603	128/136 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	271	1.000	Domainoid score	I1821
eggNOG	1	0.900	-	-		E2759_KOG0417
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2691
Isobase	1	0.950	-	0	Normalized mean entropy	S139
OMA	1	1.010	-	-		QHG53976
OrthoDB	1	1.010	-	-		D1337945at2759
OrthoFinder	1	1.000	-	-		FOG0002573
OrthoInspector	1	1.000	-	-		otm40329
orthoMCL	1	0.900	-	-		OOG6_103488
Panther	1	1.100	-	-	O	PTHR24068
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4811
SonicParanoid	1	1.000	-	-		X1929
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820