Protein Alignment FST and Fs

DIOPT Version :9

• Sequence 1: XP_005248457.1
• Gene: FST / 10468
• HGNCID: 3971
• Length: 357
• Species: Homo sapiens
• Sequence 2: NP_652376.2
• Gene: Fs / 2768836
• FlyBaseID: FBgn0259878
• Length: 767
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 134/600 - (22%)
• Similarity: 180/600 - (30%)
• Gaps: 295/600 - (49%)

Human     6 HQPGG---LCLLL-LLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWT 66
            ||.||   :.||: |||..|   |.|.||.||.....:|:|..::.|::|:.|||.:.: |.|:|
  Fly   187 HQLGGQPLMALLIGLLLLNF---RLAAAGTCWQTHLGSGKCGQVFSTDISRSECCGSSQ-SFSYT 247

Human    67 EEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDC--------- 122
            :.:::....| :....||...|.||.|:|:...|||.||| :.:|.:|:|||||:|
  Fly   248 DRELSSVEYF-FATAIGGGVECSPCMESCKGFKCGPNKKC-VKRKGRPKCVCAPECGAALRRRTH 310

Human   123 ----------------------------------------------------------------- 122
                                                                             
  Fly   311 QQELELEQEPELEEEQQEMKPPRESRSLSSENTNFNLGLDGGQRQRADNQRKLQPRESKHRRLLI 375

Human   123 ----------------------------------------------------------------- 122
                                                                             
  Fly   376 IDSSSRSSSNLPDQPTSGRRGRVEMTGYERRRHRNNHGKHLTRSMTTGANDSFPADKTPAQSPAA 440

Human   123 ----------------------------------------------------------------- 122
                                                                             
  Fly   441 DSILAQSRLANLANANEPANDINRQSSTRVRHQHARRIEHAPNPDNGLRKRQHKQQQQHQHQHQD 505

Human   123 --------SNITWKG------------------------------------------------PV 131
                    :|.|..|                                                ||
  Fly   506 RMNTEAQSANTTVSGSGSGATNHRRISQLQHGSETAASSDLANTHDLAHLGGIYAPLPPQHSNPV 570

Human   132 CGLDGKTYRNECALLKARCK-EQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI 195
            ||.||:||..||.|.|..|: ...:|||.|:|.||.:|..|.|....|||.||....:|:.|...
  Fly   571 CGTDGRTYNTECQLRKRACRTNNAQLEVAYRGHCKNSCSGVHCLNGLTCVEDQYLMPHCIACRIE 635

Human   196 CP----EPASS----EQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCISRYSGLRKEKEK 252
            ||    :..||    .|.:||.||.||.|||.:.:..|.:||||.:||.|.|            :
  Fly   636 CPWDNLDVDSSGYDERQAVCGVDGKTYRSACDINRMICKIGRSIAVAYPGPC------------R 688

Human   253 TEAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPV---CASDNATYASECAMKEAA 314
            ....||.||:|.....||.|.:..:.||..|...|| .|...||   |..:|.||.|.|.|.:.:
  Fly   689 AGRVSCADIKCGPKDNCLVDLQTRQPRCVTCRYKCP-RKQQRPVHKICGYNNQTYNSWCEMHKHS 752

Human   315 CSSGVLLEVKHSGSC 329
            |.|...:.||..|||
  Fly   753 CESRYFIGVKSQGSC 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FST	XP_005248457.1	FOLN	94..117	CDD:128570	9/22 (41%)
		KAZAL	117..164	CDD:197624	26/307 (8%)
		FOLN	167..190	CDD:128570	8/22 (36%)
		KAZAL	192..239	CDD:197624	23/54 (43%)
		KAZAL	283..329	CDD:197624	18/48 (38%)
Fs	NP_652376.2	KAZAL	564..604	CDD:197624	18/39 (46%)
		KAZAL_FS	654..687	CDD:238052	17/32 (53%)
		KAZAL_FS	723..767	CDD:238052	17/44 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12130
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6413
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1460520at2759
OrthoFinder	1	1.000	-	-		FOG0003390
OrthoInspector	1	1.000	-	-		otm42275
orthoMCL	1	0.900	-	-		OOG6_107565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5159
SonicParanoid	1	1.000	-	-		X2287
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.660