DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MERTK and side-VI

DIOPT Version :9

Sequence 1:	NP_006334.2	Gene:	MERTK / 10461	HGNCID:	7027	Length:	999	Species:	Homo sapiens
Sequence 2:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster

Alignment Length:	801	Identity:	155/801 - (19%)
Similarity:	258/801 - (32%)	Gaps:	302/801 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    15 PALWR-------RAITEAREEAKPYPLFPGPF----PGSLQTDHTPLLSLPHASGYQPALMFSPT 68
            |:.||       ||:....:|  |..|...|.    .|:.:......||....|.....::..||
  Fly    83 PSHWRDEEVLEDRAVFRTHKE--PAELIINPVKEKDAGNFRCRVDFKLSQTRNSNVNLEVVVPPT 145

Human    69 QPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSI---SVPNIYQDTTISW 130
            ||      .:...:...::|:..|            ..|...::..|.:   |.|     .|:.|
  Fly   146 QP------IIFNERRLRIDSRAGP------------YEEGGSLEVTCVVYGGSPP-----PTVIW 187

Human   131 WKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQG 195
            ..:|:    ..:::..:..|..:.:.:...:::.:.:  :..|.|:....:::.|:..|.|::..
  Fly   188 LMNGQ----LQNSVVDYTYDGAINSKLVVRNLSRIHQ--HAVYTCQASNFHKKYVATNITIDLYL 246

Human   196 LP-----HFTKQPESMNVTRNTAFNLTCQAVGPPEPVNI-FWVQN------SSRVNEQPEKSPSV 248
            .|     .|..||  |:..|.  :.:.|||:|...|..| :|:.|      |.:|:|....|.||
  Fly   247 RPLLVEISFNNQP--MSADRK--YEIECQAIGSRPPAKITWWMGNLELHGHSQKVSEDGNVSTSV 307

Human   249 LTVP---------------------GLTEMAV------------------------------FSC 262
            |::.                     |:.|.|:                              |.|
  Fly   308 LSITPTREDHGKALSCRATNELVRNGIRETAMKLNVFFIPTLQLDLGSNLNPEDIEEGDDVYFEC 372

Human   263 EA-------------------HNDK-GLTVSKGVQINIKAIPSPPTEVSIRNSTAH-----SILI 302
            :.                   ||.: |:.||.|             :::::..|.|     :...
  Fly   373 KVHANPAAYKVVWKHNHQIIQHNQRAGVIVSSG-------------DLALQGVTRHQAGNYTCTA 424

Human   303 SWVPGFDG----------YSPF------------RN------CSIQVKEADPLSNGSVMIFNTSA 339
            |.|.| ||          |.|.            ||      |.:   :|.|........||.:|
  Fly   425 SNVEG-DGDSNVVELKVMYKPICRPDQKKIYGVARNEAAEIVCEV---DAFPPPENFKWSFNNTA 485

Human   340 ----------LPHLYQ--------IKQLQALANYSIG-VSCM--NEIGWSAVSPWILASTTEGAP 383
                      .||..|        :|::      ..| :.|.  |.:| ....|.:......|.|
  Fly   486 ETFDMPQSGFRPHSAQGSTLTYTPVKEM------DFGTIMCWADNNVG-QQKEPCVFHLIAAGKP 543

Human   384 SVAPLNVTVFLNESSDNVDI-----------RW-MKPPTKQQDGELVGYRISHVWQSAGISKELL 436
            . ||.|.|| :|::||::::           :| :.....|..|:|          .|.||.:.
  Fly   544 E-APTNCTV-VNQTSDSLEVYCIEGFDGGMRQWFLMEIFDQHSGQL----------QANISAKF- 595

Human   437 EEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYA-----------P 490
                     |.:||...:|....||......|.|. ||.:.:    .|:...|           .
  Fly   596 ---------AALSVTGLDAGRLFRIYVYAVNGRGR-SDAIAL----DGYTLKAAEKQTVALTSYK 646

Human   491 SSTPAPGNAD--PVLIIFGCFCGFIL------IGLILYISLAIRKRVQETKF--GNAFTEEDSEL 545
            .|..:|.|.:  |:|.| |.|.|.::      ||.|..:.|...|..|:.||  .||.......|
  Fly   647 GSAQSPDNFELTPILSI-GIFVGILVAIVCIGIGTIAALKLRSHKHQQQQKFVHPNAKFSRPGNL 710

Human   546 VVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQED 610
            .:         :..|.|.|..   |||:.::....|:..|               .::|..||:.
  Fly   711 QI---------KDKISLPLSH---SEEMYDEKNPDVVPYN---------------EVDGEYKQKS 748

Human   611 GTSLKVAVKTMKLDNSSQREI 631
            .|.    ..:..|..:|:.||
  Fly   749 ATQ----TPSGHLSTTSEVEI 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MERTK	NP_006334.2	IG	111..193	CDD:214652	12/84 (14%)
		Ig	111..176	CDD:143165	8/67 (12%)
		Ig2_Tyro3_like	199..279	CDD:143226	31/157 (20%)
		IG_like	203..280	CDD:214653	29/154 (19%)
		FN3	284..378	CDD:238020	26/147 (18%)
		FN3	386..478	CDD:238020	25/103 (24%)
		PTKc_Mer	579..862	CDD:271106	10/53 (19%)
		Pkinase_Tyr	587..854	CDD:285015	8/45 (18%)
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	13/58 (22%)
		Ig_3	157..230	CDD:290638	12/95 (13%)
		IG_like	165..242	CDD:214653	12/87 (14%)
		Ig	265..343	CDD:299845	18/79 (23%)
		IG_like	267..343	CDD:214653	18/75 (24%)
		IG_like	363..440	CDD:214653	15/90 (17%)
		IGc2	364..429	CDD:197706	12/77 (16%)
		IG_like	456..532	CDD:214653	16/85 (19%)
		Ig_3	456..524	CDD:290638	14/76 (18%)
		fn3	545..622	CDD:278470	23/98 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000