Protein Alignment MERTK and side-V

DIOPT Version :9

• Sequence 1: NP_006334.2
• Gene: MERTK / 10461
• HGNCID: 7027
• Length: 999
• Species: Homo sapiens
• Sequence 2: NP_611765.2
• Gene: side-V / 37679
• FlyBaseID: FBgn0085400
• Length: 1174
• Species: Drosophila melanogaster
• Alignment Length: 486
• Identity: 89/486 - (18%)
• Similarity: 163/486 - (33%)
• Gaps: 155/486 - (31%)

Human    91 LPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDT--------------TISWWKDGKELLGAH 141
            :||.|       :.:.:|.|.:.....:.|.:..|:              .:|||::
  Fly   154 VPPTA-------LTILDHHGAEIRDQTAGPYLEGDSIDLTCLSSGGVPPPRVSWWRE-------- 203

Human   142 HAIT----QFYPDDEVTAIIASFSITSVQRSD----------NGSYICKMKINNEEIVSD----P 188
            ||:.    |..||..|..::   .:.::||.|          ||..:..:   .::::.|    |
  Fly   204 HALIDDSFQVLPDGSVRNVL---RLKNIQRKDLLTMYTCQASNGHVVPAL---TKKVILDMNLPP 262

Human   189 IYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPS------ 247
            :.:.:|||.|        .|...|..::||.|:|...|..|.|.:....|......:.|
  Fly   263 LSLLLQGLNH--------AVIAGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSSTSSDGNTTI 319

Human   248 ----VLTVPGLTEMAVFSCEAHNDKGLT---VSKGVQINIKAIPSPPTEVSIRNS----TAHSIL 301
                ::.||...|..|. |....:.|:|   :.:|....:..:.:..|.:.:::|    ..|:.:
  Fly   320 SELMLIPVPEDNERQVV-CSISLNAGITSQQLHEGHTTVMTTLGNGHTGLYLKDSRVLNVTHAPI 383

Human   302 ISWVPG--------FDGYSPFRNCSIQVKEADP---------------------LSNGSVMIFNT 337
            ::...|        ..|...:..|.:   :|:|                     :||.::::...
  Fly   384 VNLNLGAPLDPDNLLKGTDVYLECDV---KANPAITRVEWYHSDKQLHSSRGIIISNQTLVLQGI 445

Human   338 SALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWIL--ASTTEGAPSVAPLNVTVFLNESS-D 399
            |...|    .|....|:...|....||:......|.:.  .||...|.....:|:|..::.:. |
  Fly   446 SKSSH----GQYFCRASNLQGSVSSNEVYLDVKYPPVCKSESTIIRAALKQTINITCEVDANPVD 506

Human   400 NVDIRW---------------------MKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNG 443
            |::.:|                     |......|.|.   |:.|....|.|:.:.||.  |::|
  Fly   507 NLNYKWHFNNSLESLIELPQLGQGAPVMLASGSDQSGY---YQRSKRKHSHGMQQRLLH--GRHG 566

Human   444 SRARISVQVHNATCTVRIAAVTRGGVGPFSD 474
            ..|           .||.......|.|.|.:
  Fly   567 RMA-----------AVRFEDEDEDGYGEFEE 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MERTK	NP_006334.2	IG	111..193	CDD:214652	18/113 (16%)
		Ig	111..176	CDD:143165	16/92 (17%)
		Ig2_Tyro3_like	199..279	CDD:143226	19/92 (21%)
		IG_like	203..280	CDD:214653	19/89 (21%)
		FN3	284..378	CDD:238020	18/128 (14%)
		FN3	386..478	CDD:238020	22/111 (20%)
		PTKc_Mer	579..862	CDD:271106
		Pkinase_Tyr	587..854	CDD:285015
side-V	NP_611765.2	Ig	42..153	CDD:299845
		IG_like	42..152	CDD:214653
		IGc2	179..245	CDD:197706	14/76 (18%)
		IG_like	179..245	CDD:214653	14/76 (18%)
		Ig	<282..348	CDD:299845	16/66 (24%)
		IGc2	400..459	CDD:197706	10/65 (15%)
		FN3	719..798	CDD:214495

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000