Protein Alignment TACC3 and Rok

DIOPT Version :9

• Sequence 1: XP_005247986.1
• Gene: TACC3 / 10460
• HGNCID: 11524
• Length: 842
• Species: Homo sapiens
• Sequence 2: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 123/607 - (20%)
• Similarity: 200/607 - (32%)
• Gaps: 221/607 - (36%)

Human   365 PPLRKAAVRQQKAPQEVEEDDGRS----GAGEDP----PMPASRGSYHLDWDKMDDPNFIPFGGD 421
            ||:         .|:...:||.|:    ...|.|    |:|           |..|.|.:||.|.
  Fly   364 PPV---------VPELSSDDDTRNFEDIERDEKPEEVFPVP-----------KGFDGNHLPFIGF 408

Human   422 TKSG-----CSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAET 481
            |.:|     .|:....||.|       |...::|.|:...|       |..:....|
  Fly   409 TYTGDYQLLSSDTVDAESKE-------ANVANSGAASNNHG-------HGHNHRHRP-------- 451

Human   482 PTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDYLEQFGT 546
                |....|......|......||          |||.::...|...|:: |..|.: |::..:
  Fly   452 ----SNSNELKRLEALLERERGRSE----------ALEQQDAGLRQQIELI-TKREAE-LQRIAS 500

Human   547 SSFKESALRKQSLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPR-----------EAKL 600
            ...|:.|||:.:..:....:.::...|....|....:..........|.|           |.:|
  Fly   501 EYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQL 565

Human   601 VEFD---------------FLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQK-------- 642
            :|.:               ....||..|......|          ..:||::...||
  Fly   566 LEMEQSYKTETENTQKLKKHNAELDFTVKSQEEKV----------RDMVDMIDTLQKHKEELGQE 620

Human   643 --DLDAVV------RTQVK-------------------------ATQEENRELRSRCEELH---- 670
              :|.|:|      |:|:|                         ..||:||.|..:..:|.
  Fly   621 NAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHA 685

Human   671 GKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAE--------IQKVLKEKD--QLTTDLNSMEKS 725
            |.:.||.....|:::.| :|.:|.:|.:.:|:.|        :|..|.|:.  ::..|.:|.||
  Fly   686 GLDFELKAAQGRYQQEV-KAHQETEKSRLVSREEANLQEVKALQSKLNEEKSARIKADQHSQEK- 748

Human   726 FSDLFKRFEKQKEVIE-GYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEE----------KL 779
                    |:|..::. .||:.:..|:|..    ....||.::..||::..::          :|
  Fly   749 --------ERQLSMLSVDYRQIQLRLQKLE----GECRQESEKVAALQSQLDQEHSKRNALLSEL 801

Human   780 QLANEEIAQVRSK---------------------------AQAEALA----LQASLRKEQMRIQS 813
            .|.:.|:|.:||:                           ...||||    |||.|..||. ...
  Fly   802 SLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALANNRELQAQLEAEQC-FSR 865

Human   814 LEKTVEQKTKEN--EELTRICD 833
            |.||...:.:|.  |.|::|.|
  Fly   866 LYKTQANENREESAERLSKIED 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TACC3	XP_005247986.1	TACC	639..836	CDD:282818	65/294 (22%)
		iSH2_PI3K_IA_R	656..>757	CDD:304922	29/115 (25%)
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	17/66 (26%)
		S_TKc	87..349	CDD:214567
		SbcC	484..1088	CDD:223496	86/431 (20%)
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000