Protein Alignment TACC3 and tacc3

DIOPT Version :10

• Sequence 1: NP_001428233.1
• Gene: TACC3 / 10460
• HGNCID: 11524
• Length: 849
• Species: Homo sapiens
• Sequence 2: NP_997746.1
• Gene: tacc3 / 321283
• ZFINID: ZDB-GENE-050522-327
• Length: 942
• Species: Danio rerio
• Alignment Length: 1007
• Identity: 319/1007 - (31%)
• Similarity: 481/1007 - (47%)
• Gaps: 227/1007 - (22%)

Human     1 MSLQVLNDKNVSNEKNTEN---CD-FLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTPL 61
            ||...|.:...:...|:.:   || |:...|  |||.|:||.||.:|: .:...:|.||.||||.
Zfish     1 MSSDALKENQGAVRMNSNSEFACDIFMLDQP--TGRPSILRQSQADNI-NRTAPRAAKVCFQTPR 62

Human    62 RDPQTHRILSPSMASKLEAPFTQDD------TL-GL-------ENSHPVWTQKE-NQQLIKEVDA 111
            |||.|.:|:|||..|:   |.:|||      || ||       .|:|......| |...:.:.|
Zfish    63 RDPVTKKIMSPSRTSR---PISQDDHKNALETLTGLSDQSSLMNNTHTTPIDIECNSVALPDDD- 123

Human   112 KTTHGILQKPVEA------DTDLLGDASPAFGSGSSSESGP-------GALADLDCSSSSQSPGS 163
                    .||::      |.|.:...:|..||...:.|.|       .|.::|..|:::.:|.|
Zfish   124 --------MPVQSRGAYSFDLDNIDAINPFQGSNKMANSPPKSSAFTEAATSELVESNTTIAPVS 180

Human   164 S-ENQMVSPGKVSGSP-EQA---VEENLSS-----YSLDRRVTPA-SETLEDPCRTESQHKAETP 217
            : :.::.:..:|:.|. |:|   ||.:|:.     .|.:..|.|. :...|.|..|||......|
Zfish   181 APQVEVETEAEVTDSAFEEAVPSVENSLAECSANISSTEGNVAPVLAPQAEVPEVTESALDETLP 245

Human   218 -----HGAEEEC-------------KAETPHGAEEECRHGGVCAPAAVATSPPGAIPKEACGGAP 264
                 ..:..||             |.|....:..|.....:..|.|    .|..||  ...|.|
Zfish   246 FVPSVENSLAECSANLSSAEGTVILKTENIENSTNETEETEITDPVA----EPQQIP--VFEGQP 304

Human   265 -LQGLPGEALGC--------------PAGVGTPVP-ADGTQTLT---------------CAHTSA 298
             .|.||..:.|.              ..| |:.:| :..|:|.|               ...|..
Zfish   305 EAQDLPLPSAGSYKLDFDNLEMLNPFQTG-GSKIPNSPPTKTSTVFDPPLLSHEPEQELSVQTDI 368

Human   299 PESTAPTNHLVAGRAMTLSPQEEVAAGQMASSS---RSGPVKLEFDVSDGATSKRAPPPRRLGER 360
            |.|:.|          :::|||...|.:.:||:   :...:.|||:..|||..||.|||:|||.:
Zfish   369 PTSSDP----------SITPQENSTATESSSSTTAPKESQMLLEFNFDDGAEVKRKPPPKRLGVK 423

Human   361 S--GLKPPLRK--AAVRQQK----------APQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMD 411
            .  |.||..:|  |.|.::|          :|:|.:..|          :|:::|||..|:::.|
Zfish   424 RTVGAKPVPKKTDALVTEKKDAEPKQMSPTSPEETQPVD----------IPSAKGSYTFDFEQFD 478

Human   412 DPNFIPFGGDTKSGCSEAQPPE----SPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDT 472
            :|||.|||.....|.|   ||.    ||..:..|...:||...||.::.....|.|:.|.|.|:
Zfish   479 NPNFNPFGTKAMMGNS---PPRGVQTSPVLKKAQSPVKQLETLPAQDDQPEQRSPQVVSESKEN- 539

Human   473 PVVQLAAETPTAESKERALN-SASTSLP-TSCPGSEPVPTHQQGQPALELKEESFRD-------- 527
               .:.|..|  |:||.|.: .:|.::| |..|.:..||     :|......||..|
Zfish   540 ---MVEANLP--ETKELAEDVESSMAVPHTDKPQNPAVP-----EPDFMAVPESIADIQNQTCDL 594

Human   528 -----------PAEVLGTG----AEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGR---- 573
                       |..:...|    .::|||||||:|:|||||||||||||||||||::||.:
Zfish   595 GVAASNEDEFVPGALFMPGGDFDGQIDYLEQFGSSNFKESALRKQSLYLKFDPLLKESPKKNGGE 659

Human   574 --------PVPVATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPG-----VPAPGG 625
                    |.| :.....|..|......:.:...:...|.|..|.:....|.|.     |||...
Zfish   660 GSNFGFCMPRP-SLAIRMMEAAKSEVKQKSQCDSVKLLDDLPPLAVETVVPDPTVLDLLVPALKP 723

Human   626 PPLSTGPIVDLLQYSQKDLDAVV----KATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQA 686
            |..:...|:::|:|||||:||.:    :.::|..:||:|:.|:|..:|.::..||..||..:.|.
Zfish   724 PVRTEDSIIEVLKYSQKDMDAALQKADRQSEERQQELKSQIEKLQLENQQMLFIMSEFETTITQI 788

Human   687 MEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVE 751
            .:|.::::.|:|.|:::||:|||||..|||.:|:|||.:.||.::.||||||::||||:||:..:
Zfish   789 TDEHKQKEALAKMEMERVLEEKDQLAKDLNELERSFSSVVKRLDRCKEVIEGFKKNEETLKQYAK 853

Human   752 DYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQ 816
            :.:.|:.:|.:|||||||||||||:.||:.||:||:|..||..|||..|::||:::|||||.:||
Zfish   854 NCMDRLQKEEKRYQALKAHAEEKLEQANKAIAEVRTKQGAEVAALQVQLKREQLKVQSLEKDLEQ 918

Human   817 KGEAPQLIFLLQTKENEELTRICDDLISKMEK 848
            |           .||.:::|.:||:|:.|::|
Zfish   919 K-----------AKEVKDVTELCDELLLKVQK 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TACC3	NP_001428233.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	123..227		31/145 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..527		73/238 (31%)
		Necessary but not sufficient for spindle localization. /evidence=ECO:0000269|PubMed:23918938	522..577		35/89 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	569..594		6/36 (17%)
tacc3	NP_997746.1	SDP repeat 1	316..347		5/31 (16%)
		SDP repeat 2	469..502		14/35 (40%)
		TACC_C	737..934	CDD:461517	94/207 (45%)
		TACC domain	746..942		90/205 (44%)