DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BAIAP2 and IRSp53

DIOPT Version :9

Sequence 1:	NP_001372058.1	Gene:	BAIAP2 / 10458	HGNCID:	947	Length:	585	Species:	Homo sapiens
Sequence 2:	NP_729679.2	Gene:	IRSp53 / 39258	FlyBaseID:	FBgn0052082	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	143/563 - (25%)
Similarity:	256/563 - (45%)	Gaps:	123/563 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     6 SEEMHRLTENVYKRVEEKYQRNLFPIFSPSALKPESRNFRGESWQGTIMEQFNPSLRNFIAMGKN 70
            :||:.:|.:.||:                                 .|:::|||..|..||.||:
  Fly     3 AEEVTKLVDGVYR---------------------------------NILDRFNPGARQLIAAGKS 34

Human    71 YEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELL 135
            |.|||.|...|::.:.:||.|:...|.:| |:.::|..|..:..|:::||:|...:||:|:.:||
  Fly    35 YLKALHGAATASRLFNEALAKIAMNAQQS-GTGDIGSALMSVVNVNKEIQDQQMNILKAFYVDLL 98

Human   136 TQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDA 200
            ..||..:|.|::.:....||:..:.:.:.::..|..:.:||.|||....:|    ::|||:.:..
  Fly    99 VPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQKAVSTMKKQRKKKATPEN----TEKELRSLQL 159

Human   201 ISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACAD 265
            :.:::.:|:.:....||.|:|:||||:.|::|:||::||:...||:.||.::......||:..|.
  Fly   160 LEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQCSIAKHWMVYHTTGKTVIDNNFENWQEIAAS 224

Human   266 PSKIPERAVQLMQQVAS--NGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQES 328
            ...||..|.:.....::  |...:.|:.|:..:|.                     .|.|...|.
  Fly   225 REIIPPAAYESGYSTSNGHNNNNISSSSSSGNNNT---------------------SGNMRRLER 268

Human   329 TPIMNGVTGPDGED----------------YSPWADRKAAQPKSLSPPQSQSKLSDS----YS-N 372
            .        .||:|                .:|:.|.     ::|...::.|.|..:    |: |
  Fly   269 I--------KDGDDDHLQGHGAQLKKSRSIDAPYGDM-----RTLHERENLSGLGGTGPAHYAQN 320

Human   373 TLPVRKS-----VTPKNSYATTENKTLPRSSSMAAGLERNGRMR--VKAIFSH-AAGDNSTLLSF 429
            :||..||     :......:..::|.:....: ..|.::.|..|  |||:::: .:|:|.  |||
  Fly   321 SLPRAKSDFNLALVGTGQSSANKHKIIEEQLA-TLGDDQRGDQRPLVKALYAYMPSGENQ--LSF 382

Human   430 KEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYT-----RVLDSDGS--DRLHMSLQQ----- 482
            :|||.|.|:..:|: ||.:||:.:|:..||||.:||     .|..|.|.  :.:.||.::
  Fly   383 EEGDRIALVGGKAK-GWQFGENLRTQHFGWFPVAYTNAEVAEVTTSGGRRYENMLMSYERNGGGS 446

Human   483 GKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYS 525
            |..|..|.|.....    ..||.|......:..|:..::|.:|
  Fly   447 GSGSGGGGLRSYQQ----QQDYEAQLELMESHEATYRRRRNHS 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BAIAP2	NP_001372058.1	I-BAR_IMD_IRSp53	5..269	CDD:153330	75/262 (29%)
BAIAP2	NP_001372058.1	SH3_Irsp53	410..468	CDD:212848	26/65 (40%)
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	74/255 (29%)
IRSp53	NP_729679.2	SH3_Irsp53_BAIAP2L	364..419	CDD:212713	25/57 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160097
Domainoid	1	1.000	141	1.000	Domainoid score	I4718
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002273
OrthoInspector	1	1.000	-	-		otm42267
orthoMCL	1	0.900	-	-		OOG6_108785
Panther	1	1.100	-	-	O	PTHR14206
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4928
SonicParanoid	1	1.000	-	-		X1500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.830