Protein Alignment PPIE and cyp33

DIOPT Version :10

• Sequence 1: NP_001181936.1
• Gene: PPIE / 10450
• HGNCID: 9258
• Length: 314
• Species: Homo sapiens
• Sequence 2: NP_523773.1
• Gene: cyp33 / 36984
• FlyBaseID: FBgn0028382
• Length: 300
• Species: Drosophila melanogaster
• Alignment Length: 281
• Identity: 187/281 - (66%)
• Similarity: 226/281 - (80%)
• Gaps: 5/281 - (1%)

Human     1 MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETEKHRGFAFVEFELAEDAAAAID 65
            |:..||.:||||||:||.:::|:.||||||||.|||:|.|||:::||||||:|:|.:||||||||
  Fly     1 MSNDKRTIYVGGLADEVTERLLNNAFIPFGDIADIQMPADYESQRHRGFAFIEYEQSEDAAAAID 65

Human    66 NMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDDWLKKFSGKTLEENKEEEGSEPPKAETQEGE 130
            |||:|||.|||||||||||:|:||.|.:|:|:|||||:|.:|.||:...|.|..   |.||....
  Fly    66 NMNDSELCGRTIRVNLAKPVRVKEDSFKPIWADDDWLQKHAGATLQPEGEPEAE---KVETPSTG 127

Human   131 P--IAKKARSNPQVYMDIKIGNKPAGRIQMLLRSDVVPMTAENFRCLCTHEKGFGFKGSSFHRII 193
            |  |.|..:.||||:.||:||...||||.||||:||||.||||||.|||||:|:|:||.||||:|
  Fly   128 PAVIEKAEKRNPQVFFDIRIGGNDAGRIVMLLRADVVPKTAENFRQLCTHEQGYGYKGCSFHRVI 192

Human   194 PQFMCQGGDFTNHNGTGGKSIYGKKFDDENFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTDWL 258
            |:||||||||||:|||||||||||||:||||.|||...|.|||||||.||||||||:...|||||
  Fly   193 PEFMCQGGDFTNNNGTGGKSIYGKKFNDENFNLKHNSFGTLSMANSGANTNGSQFFICTTKTDWL 257

Human   259 DGKHVVFGEVTEGLDVLRQIE 279
            |.||||||.|..|.:|:|::|
  Fly   258 DNKHVVFGHVISGAEVVRKME 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPIE	NP_001181936.1	RRM_PPIE	8..82	CDD:409783	53/73 (73%)
		cyclophilin_ABH_like	140..279	CDD:238907	102/138 (74%)
cyp33	NP_523773.1	RRM_PPIE	8..82	CDD:409783	53/73 (73%)
		cyclophilin_ABH_like	139..297	CDD:238907	103/140 (74%)