DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARIH2 and ari-2

DIOPT Version :9

Sequence 1:	NP_001336142.1	Gene:	ARIH2 / 10425	HGNCID:	690	Length:	516	Species:	Homo sapiens
Sequence 2:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	270/529 - (51%)
Similarity:	347/529 - (65%)	Gaps:	55/529 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    14 EEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMT 78
            :.|.:.:.|.:.:.|.||  |.:.|..|...|||:......|||.:::.|||.::.|..|||.:.
  Fly     2 DSDIEMDMESDNDGEYDD--DYDYYNTGEDCDVERLDPKRADPEYFEYECLTVEDIEKLLNERVE 64

Human    79 SLASVLKVSHSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNPS---------------- 127
            .|.::|:::.|:||::|:...|....::::|:.::..|||.||::| ||
  Fly    65 KLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKP-PSVAVTDTASTSAAAASA 128

Human   128 ----------KHVPTSHPPHH---CAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGV 179
                      |...::.|.:.   |.||......:...||||.|.||:.||..:....:..|:..
  Fly   129 QLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQGIST 193

Human   180 GVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRA 244
            .:.||||.|.:|.|||.|..|:....:|:||:::.|:|||:||.:|:.|||.:|.::::..|..|
  Fly   194 QIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISA 258

Human   245 RRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGG 309
            :|..|..|:..|||:|...|||||||..|:||||||||||||||||||||||||||:||||||||
  Fly   259 KRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGG 323

Human   310 CNHMQCSKCKHGEFQAWCVRPSGTFLWLGLRYYLNFCWMCLGDWKTHGSEYYECSRYKENPDIVN 374
            ||||||..|||                       :|||||||||||||||||||||||:||:|.|
  Fly   324 CNHMQCFNCKH-----------------------DFCWMCLGDWKTHGSEYYECSRYKDNPNIAN 365

Human   375 QSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKL 439
            :|...||||||||||.|:||||||:|||:||.||..|:.::|..:|||..|||||||||.|||.|
  Fly   366 ESVHVQAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAAL 430

Human   440 LAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQ 504
            |||||||||||||||||||:|.||.|||||||||||||||||||:|||::.|.|||||||.|||:
  Fly   431 LAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERAETTDLGDLENQMDIAEK 495

Human   505 RRRTLLKDF 513
            ||.||||||
  Fly   496 RRTTLLKDF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARIH2	NP_001336142.1	RING-HC_RBR_TRIAD1	137..190	CDD:319687	18/55 (33%)
		RING-HC finger (C3HC4-type)	139..188	CDD:319687	17/48 (35%)
		IBR	208..270	CDD:214763	27/61 (44%)
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	18/52 (35%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	27/61 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151489
Domainoid	1	1.000	259	1.000	Domainoid score	I1999
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48424
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1037
Isobase	1	0.950	-	0	Normalized mean entropy	S1372
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		oto90082
orthoMCL	1	0.900	-	-		OOG6_107754
Panther	1	1.100	-	-	LDO	PTHR11685
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2404
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750