Protein Alignment ARIH2 and ari-2

DIOPT Version :10

• Sequence 1: NP_001336142.1
• Gene: ARIH2 / 10425
• HGNCID: 690
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 529
• Identity: 270/529 - (51%)
• Similarity: 347/529 - (65%)
• Gaps: 55/529 - (10%)

Human    14 EEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMT 78
            :.|.:.:.|.:.:.|.||  |.:.|..|...|||:......|||.:::.|||.::.|..|||.:.
  Fly     2 DSDIEMDMESDNDGEYDD--DYDYYNTGEDCDVERLDPKRADPEYFEYECLTVEDIEKLLNERVE 64

Human    79 SLASVLKVSHSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNPS---------------- 127
            .|.::|:::.|:||::|:...|....::::|:.::..|||.||::| ||
  Fly    65 KLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKP-PSVAVTDTASTSAAAASA 128

Human   128 ----------KHVPTSHPPHH---CAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGV 179
                      |...::.|.:.   |.||......:...||||.|.||:.||..:....:..|:..
  Fly   129 QLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQGIST 193

Human   180 GVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRA 244
            .:.||||.|.:|.|||.|..|:....:|:||:::.|:|||:||.:|:.|||.:|.::::..|..|
  Fly   194 QIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISA 258

Human   245 RRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGG 309
            :|..|..|:..|||:|...|||||||..|:||||||||||||||||||||||||||:||||||||
  Fly   259 KRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGG 323

Human   310 CNHMQCSKCKHGEFQAWCVRPSGTFLWLGLRYYLNFCWMCLGDWKTHGSEYYECSRYKENPDIVN 374
            ||||||..|||                       :|||||||||||||||||||||||:||:|.|
  Fly   324 CNHMQCFNCKH-----------------------DFCWMCLGDWKTHGSEYYECSRYKDNPNIAN 365

Human   375 QSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKL 439
            :|...||||||||||.|:||||||:|||:||.||..|:.::|..:|||..|||||||||.|||.|
  Fly   366 ESVHVQAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAAL 430

Human   440 LAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQ 504
            |||||||||||||||||||:|.||.|||||||||||||||||||:|||::.|.|||||||.|||:
  Fly   431 LAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERAETTDLGDLENQMDIAEK 495

Human   505 RRRTLLKDF 513
            ||.||||||
  Fly   496 RRTTLLKDF 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARIH2	NP_001336142.1	RING-HC_RBR_TRIAD1	137..190	CDD:438429	18/55 (33%)
		BRcat_RBR_TRIAD1	217..288	CDD:439005	39/70 (56%)
		Rcat_RBR_TRIAD1	292..370	CDD:439021	49/77 (64%)
		Ariadne	375..>501	CDD:466073	95/125 (76%)
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	152..204	CDD:438429	18/51 (35%)
		BRcat_RBR_TRIAD1	231..302	CDD:439005	39/70 (56%)
		Rcat_RBR_TRIAD1	306..361	CDD:439021	49/77 (64%)
		Ariadne	371..>477	CDD:466073	83/105 (79%)