DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TESK2 and cdi

DIOPT Version :9

Sequence 1:	NP_009101.2	Gene:	TESK2 / 10420	HGNCID:	11732	Length:	571	Species:	Homo sapiens
Sequence 2:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	244/688 - (35%)
Similarity:	311/688 - (45%)	Gaps:	188/688 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    24 GGGGGEG--------NVSQVGRVWPSSYRALISAFSRLTRLDDFTCEKIGSGFFSEVFKVRHRAS 80
            ||..|.|        .:|....|..||.|||.:|.|.|..:|||..|||||||||||:||.||.:
  Fly    68 GGWIGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDFVKEKIGSGFFSEVYKVTHRTT 132

Human    81 GQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLL-DS 144
            ||||.||||.|.:||.|||:||||:|:|||.|||.||||||.:|||||||||||.|:||||| :.
  Fly   133 GQVMVLKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHALTEYINGGSLEQLLANK 197

Human   145 NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENG-YSAVVADFGLAEKIPDVS 208
            .:.|..|.:::||..||.|:||:|..|||||||||||.||:...|. |.|||.|||||.||| |.
  Fly   198 EVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQYEAVVGDFGLAAKIP-VK 261

Human   209 MGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF 273
            ....:|..||||:|::||.|:.:.|::.:||||:|||.|||||||:||||.:|||.:|||||.||
  Fly   262 SRKSRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASFGLDYLAF 326

Human   274 QHMVG-DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEE------------------ 319
            ..:.. |.||.||:|.|.||..|.|.||:|.:..|.|..:|.:.:.|
  Fly   327 VELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYEHESSAGASPLSSLELINCSP 391

Human   320 ------------------------------------EQERDRKLQPTARGLLEKAPGVKR----L 344
                                                |.:.|....|:.:......||...    .
  Fly   392 GGSDSENVTLTPRASVPTVATICTAPAGTLTPRHLQEVDEDGFRFPSKKSASAALPGTPNGSAGS 456

Human   345 SSLDDKI-------------------------------PHKSPCPR-RTIWLSRSQSDIFSRKPP 377
            |..||.|                               .|.||..: |...:.|.:|...|..||
  Fly   457 SGFDDHILKSRVRRATQKLEAEILLHRRSLSENIIHFPMHTSPSDKARCHQMQRQRSSTHSPTPP 521

Human   378 RTVS---------------------------VLDPYYRP-----RDGAARTPKVNPFSARQDLMG 410
            |.:|                           |.||.|:|     .:|:    |.|||.|...|.|
  Fly   522 RQLSSVQLPATSIPDPPPLPKPVPAVLTLRKVGDPQYKPTSEKDHNGS----KPNPFEALAQLRG 582

Human   411 GKIKFFDLPSKS-------VISLVFDLDAP---------------GPGTMP-------LADWQEP 446
            .| |..|...|:       :.|..|::.||               |.||..       .|....|
  Fly   583 VK-KILDANPKTYAAGVGDLFSSCFEMLAPFFKELAAMQSKAGAQGGGTSTEETSTGNKASAATP 646

Human   447 LAPPIRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVKEIPPFRASALPAAQAHE 511
            ..|     :|||.||....:.:...:...:.:|:..||.::|..      ||  :.|||..: .:
  Fly   647 SEP-----KSLPVSPHMTRKYSAIELRLPQRISNAAPPAVTSAP------PP--SIALPTDE-DD 697

Human   512 AMDCSILQEENGFGSRPQGTSPCPAGASEEMEVEERPA 549
            ..||      |..|..|.|...|....|...:...||:
  Fly   698 CDDC------NSEGEDPDGGGNCADAESSSDDSAVRPS 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TESK2	NP_009101.2	PKc_TESK	64..316	CDD:271057	153/254 (60%)
TESK2	NP_009101.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..571		8/29 (28%)
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	153/250 (61%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	153/254 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I1493
eggNOG	1	0.900	-	-		E2759_2QTCP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3848
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003575
OrthoInspector	1	1.000	-	-		otm42019
orthoMCL	1	0.900	-	-		OOG6_104336
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5384
SonicParanoid	1	1.000	-	-		X2054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760