back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRMT5 and csul

DIOPT Version :9

Sequence 1:	NP_006100.2	Gene:	PRMT5 / 10419	HGNCID:	10894	Length:	637	Species:	Homo sapiens
Sequence 2:	NP_477184.1	Gene:	csul / 36809	FlyBaseID:	FBgn0015925	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	242/592 - (40%)
Similarity:	345/592 - (58%)	Gaps:	34/592 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    57 EPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYL-GLP 120
            ||.::.|   |....:|||.|||:.::..:|. :..||..:|:|.:::...::::.:..:| .:.
  Fly    42 EPHESDP---TYPATILSGSDWNSKVIFTMSD-VNVDSPNDKLREHAKEVFMRDVAWAEHLQNVG 102

Human   121 AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEE-- 183
            ..::.|...:|.|||.::.........|..::::||:..|        |.|...|.::.:.||
  Fly   103 NLMVRLRGPENENLASIVLAKTKDDFPSGNWFIQVPITNP--------ELATFEHRKDATAEEVA 159

Human   184 -----KTWMWWHNFRTLCDYSKRIAVALEIG-ADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKG 242
                 ..|.||:|.|.:..:|.::.|.:|:. ||.||...:.|||||||:|.|:|:|:|:.|:..
  Fly   160 EAESNDPWNWWNNLRMVTKHSTKVKVVIELNDADRPSKETVRRWLGEPIEAIIIPSSLFVRNRSN 224

Human   243 FPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDY 307
            :.||.|..|.::...:.:....||: || .::|..|.|..|:..|..:    |..:.....||:.
  Fly   225 YCVLKKEWQLIVGHFISVRANIIIS-TN-PNDKALCQYADYVNKLIND----NCDKHMLNSYENM 283

Human   308 LQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLV 372
            |:.|||||.|||::.||||||.||:||..||.|:...|||||...|..|.:.|:|:||.|||||.
  Fly   284 LEIPLQPLCDNLDTYTYEVFETDPVKYKLYQDAVQAALLDRVSAAEAKTKLTVVMLLGGGRGPLA 348

Human   373 NASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQ-VTVVSSDMREWVAPEKADIIVSEL 436
            .|...||:...|:::||.:||||||:.||.|.....|..: |.:.|.|||::..||.|||:||||
  Fly   349 RAVFNAAELTKRKVRLYIIEKNPNAIRTLSNMVKTLWADKDVHIFSKDMRDFSPPELADIMVSEL 413

Human   437 LGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMP 501
            ||||.||||||||||||...||.||:|||.:.||::.|:.|:.|:..|  |:.....|  .|:..
  Fly   414 LGSFGDNELSPECLDGALKLLKPDGISIPYKSTSYINPLMSAVLHQNV--CQLLPTYP--AFDYG 474

Human   502 YVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLS 566
            ||..|.|.:.:..||..|.|.||||...|||.|..|:.|.|..:.||||..|||:|.||:||.||
  Fly   475 YVSLLKNIYHIDEPQALFEFVHPNRAENIDNTRCKTVSFKVNKDCVLHGIGGYFDTHLYKDICLS 539

Human   567 IRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEW-AVTAPVCSAIHNPTG 630
            |.|.||:||||||||:.|..: |.|:||||||.::||||.::.|||||| .|.:|.....||..|
  Fly   540 INPLTHTPGMFSWFPMFFATR-PRTLREGQTISIQFWRCVDATKVWYEWQVVNSPDDWEHHNTRG 603

Human   631 RSYTIGL 637
            ..|.:.|
  Fly   604 TGYNMRL 610

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.