DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPON1 and mspo

DIOPT Version :9

Sequence 1:	NP_006099.2	Gene:	SPON1 / 10418	HGNCID:	11252	Length:	807	Species:	Homo sapiens
Sequence 2:	NP_001286427.1	Gene:	mspo / 36632	FlyBaseID:	FBgn0020269	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	616	Identity:	142/616 - (23%)
Similarity:	215/616 - (34%)	Gaps:	169/616 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   124 FMSNCPV---AVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQD 185
            |:||..:   :|......|.:|......|...|.    |.::....|..|:.|:.|....|....
  Fly    38 FISNPSIYAYSVENQPDERESRDNNIKFAAEHGN----LNSNSNLNRNYYYTDDPSPVSNLNPTA 98

Human   186 S--TFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYP--RRANHWSAIIGGSHSKNYVLW 246
            |  |.......|...|.....|.|::..:..|:.:..||.||  |....|:..:|.:|:.||.|:
  Fly    99 SLATPPATQPAPQTGCTLDRLAVYKVVLHTYWTRELFPKHYPDWRPTAQWTKTLGRTHNANYALY 163

Human   247 EYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQ-----------PLNVRAA 300
            ..|..|:..|||.||.|....::....:|..   ..::.::|..|.:           ..|..||
  Fly   164 HIGQPATAAVKQFAESGRTDLLDSNAGEQQQ---VQMQLQSQMQAGKSPSGGISSGTTSFNATAA 225

Human   301 PSA-----------------------------EFS----------------VDRTRHLMSFLTMM 320
            .:|                             |||                ||....|:|.:|.:
  Fly   226 STATPTGGSGGSGGSGGSGGTGTTTAERSVFDEFSMPAIPMGAGRSEAKVFVDSNHSLVSLMTRI 290

Human   321 GPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSL--D 383
            .|||||.:|:.:.:||... .|:..|..:|.|.|||||:|.|:.:||.||.||..|..:||.  .
  Fly   291 VPSPDWFIGVDSFELCVGG-SWIDTVTVELDPLDAGTDNGFTFTAPNWPTEPQGVIYRITSRYPG 354

Human   384 HPQSPFYDPEGGSITQVARVVIERIA--RKGEQCNIVPD-----------------NVDDIVADL 429
            ||...||.|:...:..:|.....::.  ...|..||..|                 |..::..:|
  Fly   355 HPAGSFYYPKSKRLPPIATFQFIKLKEYELSEVFNIAEDDRKYETVQTQTHLDAEHNHVEMNNEL 419

Human   430 APEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCP---DTQDFQPCMG 491
            :...:.|..|.:..:..|           .|:.:|:|.::| |:::     |   .....||..|
  Fly   420 SASIERERQTEQQQLQQN-----------DDERQRIRSQLL-AKMN-----PIYGSNNSLQPAPG 467

Human   492 -------------------------PGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQF 531
                                     ...||.:.|..|.|. |.......:.|.|..:|.|...|.
  Fly   468 QVVSVVPKNDKHAILQSIASSYRRAADASDANASKPTPSA-IGGGKAGGAVGGGAATRRRSSAQR 531

Human   532 PEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHR-MIKMNPADGSMC 595
            ..|                        |.::.|.||..||.:||:|...|:| :||.....|..|
  Fly   532 RRD------------------------CRVSHWSEWTACSKSCGVGEMHRYRKVIKHGKRGGRQC 572

Human   596 KAETSQAEKC-MMPECHTIPCLLSPWSEWSD 625
            .| ..|::.| ....||.    ...:..|||
  Fly   573 PA-LQQSKWCGTERNCHG----SQTYFNWSD 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPON1	NP_006099.2	Reeler	43..182	CDD:260081	13/60 (22%)
		Spond_N	205..392	CDD:310815	69/246 (28%)
		TSP_1	446..494	CDD:306574	10/75 (13%)
		TSP_1	505..554	CDD:306574	8/48 (17%)
		TSP_1	562..610	CDD:306574	17/49 (35%)
		TSP_1	618..665	CDD:306574	3/8 (38%)
		TSP_1	672..720	CDD:306574
		TSP_1	758..807	CDD:306574
mspo	NP_001286427.1	Spond_N	120..363	CDD:283999	69/246 (28%)
mspo	NP_001286427.1	TSP1	537..588	CDD:214559	17/51 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3762
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850