DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPON2 and mspo

DIOPT Version :9

Sequence 1:	NP_001121797.2	Gene:	SPON2 / 10417	HGNCID:	11253	Length:	331	Species:	Homo sapiens
Sequence 2:	NP_001286427.1	Gene:	mspo / 36632	FlyBaseID:	FBgn0020269	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	139/508 - (27%)
Similarity:	195/508 - (38%)	Gaps:	185/508 - (36%)

- Green bases have known domain annotations that are detailed below.

Human     2 ENPSPAAALGKALCALLLATLGAAGQPLGGESICSARALAKYSITFTGKWSQTAFPKQYPLFRPP 66
            ::|||.:.|.....   ||| ..|.|| ..::.|:...||.|.:.....|::..|||.||.:||.
  Fly    86 DDPSPVSNLNPTAS---LAT-PPATQP-APQTGCTLDRLAVYKVVLHTYWTRELFPKHYPDWRPT 145

Human    67 AQWSSLLGAAHSSDYSMWRKNQYVSNGLRDFAE----------RGEAWALMKEIEA---AGE--- 115
            |||:..||..|:::|:::...|..:..::.|||          .||...:..::::   ||:
  Fly   146 AQWTKTLGRTHNANYALYHIGQPATAAVKQFAESGRTDLLDSNAGEQQQVQMQLQSQMQAGKSPS 210

Human   116 ----------------------------------------ALQSVHAVFSAPAVPSGTGQTSAEL 140
                                                    |.:||...||.||:|.|.|::.|::
  Fly   211 GGISSGTTSFNATAASTATPTGGSGGSGGSGGSGGTGTTTAERSVFDEFSMPAIPMGAGRSEAKV 275

Human   141 EVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGDRWREQAALDLYPYDAGTDSGFTFSSPNFATI 205
            .|...|||||.:.|||||||||:||||.:||.|..|.:...::|.|.|||||:||||::||:.|.
  Fly   276 FVDSNHSLVSLMTRIVPSPDWFIGVDSFELCVGGSWIDTVTVELDPLDAGTDNGFTFTAPNWPTE 340

Human   206 PQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVRL-------------------------- 244
            ||..:..|||..|.|||.|||||:.|.|||||....::|
  Fly   341 PQGVIYRITSRYPGHPAGSFYYPKSKRLPPIATFQFIKLKEYELSEVFNIAEDDRKYETVQTQTH 405

Human   245 -----------------------------------RQSPRA--------------FIPPAP---- 256
                                               ||..|:              .:.|||
  Fly   406 LDAEHNHVEMNNELSASIERERQTEQQQLQQNDDERQRIRSQLLAKMNPIYGSNNSLQPAPGQVV 470

Human   257 -VLPSRDNEIV---------------DSASVPETP---------------------------LDC 278
             |:|..|...:               |:.:...||                           .||
  Fly   471 SVVPKNDKHAILQSIASSYRRAADASDANASKPTPSAIGGGKAGGAVGGGAATRRRSSAQRRRDC 535

Human   279 EVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPD-NC 330
            .||.||.|..|...|| :|...|.|.|.......|..||.|::...|..: ||
  Fly   536 RVSHWSEWTACSKSCG-VGEMHRYRKVIKHGKRGGRQCPALQQSKWCGTERNC 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPON2	NP_001121797.2	Spond_N	41..228	CDD:399462	85/242 (35%)
SPON2	NP_001121797.2	TSP1_spondin	278..330	CDD:408798	18/52 (35%)
mspo	NP_001286427.1	Spond_N	120..363	CDD:283999	85/242 (35%)
mspo	NP_001286427.1	TSP1	537..588	CDD:214559	19/52 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3931
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40843
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3611
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0007149
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_110191
Panther	1	1.100	-	-	LDO	PTHR11311
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3762
SonicParanoid	1	1.000	-	-		X5251
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860