Protein Alignment YAP1 and RSP5

DIOPT Version :10

• Sequence 1: XP_005271435.1
• Gene: YAP1 / 10413
• HGNCID: 16262
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_011051.3
• Gene: RSP5 / 856862
• SGDID: S000000927
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 562
• Identity: 122/562 - (21%)
• Similarity: 207/562 - (36%)
• Gaps: 173/562 - (30%)

Human    20 PSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDS------------ETDLEALFNAV 72
            ||..|..|.|   .|..|.::|..:......||.....|..|            |:.|::...|.
Yeast   139 PSSSPHSQAP---SGHTASSSTNTSSTTRTNGHSTSSTRNHSTSHPSRGTAQAVESTLQSGTTAA 200

Human    73 MNPKTANVPQT-------------------VPMRLRKLPDSFFKPPEPKSHSR----------QA 108
            .|..|.:...|                   :|....:..|:|.:......::|          |.
Yeast   201 TNTATTSHRSTNSTSSATRQYSSFEDQYGRLPPGWERRTDNFGRTYYVDHNTRTTTWKRPTLDQT 265

Human   109 STDAGT-AGALTPQHVRAH-----------SSPASLQLGAVSPGTLTPTGVVSGPAATP------ 155
            ..:.|. ..|.|....|.|           :|..::|:|.   |:..|.  |:|.||..
Yeast   266 EAERGNQLNANTELERRQHRGRTLPGGSSDNSSVTVQVGG---GSNIPP--VNGAAAAAFAATGG 325

Human   156 TAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPV 220
            |...|.:          ||:|||...|..|:.||::|..:||||.|||:.  ..:....||:..:
Yeast   326 TTSGLGE----------LPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQ--QYIRTYGPTNTTI 378

Human   221 QQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLD-------PRFGKAMNQRISQS 278
            ||..: |..||||.|||..:|....:|:::|..|||:|.||||.       |::.:...:::..
Yeast   379 QQQPV-SQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKVIY- 441

Human   279 APVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQAMRNINPST 343
              .:..|.|.       ::.|     |..:::::..:.::    ..||::||
Yeast   442 --FRSQPALR-------ILPG-----QCHIKVRRKNIFED----AYQEIMRQ------------- 475

Human   344 ANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSS-DPFLNSGTYHSRDESTDSG 407
              :|:    .|:.:| .::.||  :..:...|:|:|...:.::.. :||.....|.:.|
Yeast   476 --TPE----DLKKRL-MIKFDG--EEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYD------ 525

Human   408 LSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMN-- 470
                :|::...|:..:|                |...|    |.:.| |..|.||......::
Yeast   526 ----NYTIQINPNSGIN----------------PEHLN----YFKFI-GRVVGLGVFHRRFLDAF 565

Human   471 IEGEELMPSLQEALSSDILNDMESVLAATKLDKESF--LTWL 510
            ..|......|::.:   :|.|||.|      |.|.:  |.|:
Yeast   566 FVGALYKMMLRKKV---VLQDMEGV------DAEVYNSLNWM 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YAP1	XP_005271435.1	WW	174..203	CDD:238122	14/28 (50%)
		WW	231..263	CDD:197736	15/31 (48%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	122/562 (22%)