Protein Alignment YAP1 and yap1

DIOPT Version :10

• Sequence 1: XP_005271435.1
• Gene: YAP1 / 10413
• HGNCID: 16262
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_001132952.1
• Gene: yap1 / 561411
• ZFINID: ZDB-GENE-030131-9710
• Length: 442
• Species: Danio rerio
• Alignment Length: 467
• Identity: 364/467 - (77%)
• Similarity: 392/467 - (83%)
• Gaps: 36/467 - (7%)

Human    48 PPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDA 112
            |||||||||||||||||||||||||||||...||.:|||||||||||||.|||||||||||||||
Zfish     8 PPAGHQIVHVRGDSETDLEALFNAVMNPKNTIVPPSVPMRLRKLPDSFFTPPEPKSHSRQASTDA 72

Human   113 GTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGW 177
            ||||.:||.|||||||||||||||||||.||.    .|||..| .|||||||:|||||:|||.||
Zfish    73 GTAGTVTPHHVRAHSSPASLQLGAVSPGALTS----MGPANAP-PQHLRQSSYEIPDDMPLPPGW 132

Human   178 EMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSP-PV-QQNMMNSASGPLPDGWEQAM 240
            |||||.|||||||||.||||||||||||:| |||..||.|| || |||:||.||||||||||||:
Zfish   133 EMAKTPSGQRYFLNHNDQTTTWQDPRKALL-QMNQAAPASPVPVQQQNIMNPASGPLPDGWEQAI 196

Human   241 TQDGEIYYINHKNKTTSWLDPRLDPRFGKAMN-QRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQ 304
            |.:||||||||||||||||||||||||  ||| |||||||||||...| |.|||.|||.|:|
Zfish   197 TSEGEIYYINHKNKTTSWLDPRLDPRF--AMNQQRISQSAPVKQGSQL-PSSPQSGVMSGNN--- 255

Human   305 QQQMRLQQLQMEKERLRLKQQELLRQVRPQAMRNINPSTANSPKCQELALRSQLPT-LEQDGGTQ 368
              .:||||:.:||||||:| |||||| ||                ||||||:|||| :|||||||
Zfish   256 --PIRLQQIHIEKERLRIK-QELLRQ-RP----------------QELALRNQLPTSMEQDGGTQ 300

Human   369 NPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGD 433
            ||||||||.|:.|.|||||||||||||||||||||||||||||||||||||||||||||||:|||
Zfish   301 NPVSSPGMGQDARNMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMETGD 365

Human   434 TINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAA 498
            |:...::.:|.:||||||:|||||:||||||||:.|.:|||||||||||||||||||||||||||
Zfish   366 TLGPGSMATQPSRFPDYLDAIPGTDVDLGTLEGESMAVEGEELMPSLQEALSSDILNDMESVLAA 430

Human   499 TKLDKESFLTWL 510
            ||:|||:|||||
Zfish   431 TKIDKENFLTWL 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YAP1	XP_005271435.1	WW	174..203	CDD:238122	25/28 (89%)
		WW	231..263	CDD:197736	28/31 (90%)
yap1	NP_001132952.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..89		33/37 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	97..116		12/23 (52%)
		HUL4	<106..>232	CDD:227354	105/129 (81%)
		WW	127..158	CDD:197736	27/30 (90%)
		WW	188..217	CDD:459800	25/28 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..254		17/24 (71%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:P46937	247..442		159/217 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..374		73/87 (84%)