DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YAP1 and ctrip

DIOPT Version :9

Sequence 1:	XP_005271435.1	Gene:	YAP1 / 10413	HGNCID:	16262	Length:	510	Species:	Homo sapiens
Sequence 2:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	99/459 - (21%)
Similarity:	155/459 - (33%)	Gaps:	107/459 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    12 APQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPK 76
            |....|......|.|||...|.|...|.||:::               :|.:....:..::| |.
  Fly   534 ATTSSGYQQRAAPHGQGAAPGAGGGGPRATRSS---------------NSNSSNNVVDYSIM-PH 582

Human    77 TANVPQTVPMRLRKLPDSF---FKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVS 138
            ...|..|.|..|  .|...   .:||:|.||.:|..........|.|.|..||.|
  Fly   583 LTTVATTTPHAL--TPQQHQQQRQPPQPPSHQQQQVHQQQQPPQLLPTHQFAHLS---------- 635

Human   139 PGTLTPTGVVSGPAAT---PTA---------------QHLRQSSFEIPDDVPLPAGWEMAKTSSG 185
             ..:|||...:..||.   |.|               ||..|.........|.|..:..:.....
  Fly   636 -SFVTPTAAAAAAAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLH 699

Human   186 Q---RYFLNHIDQTTTWQDPRKAMLSQM---------NVTAPTS----PPVQQNMMNSASGPLPD 234
            |   .:|      |:|...|..|:..|.         ..||.|:    ||.||.::.:     |.
  Fly   700 QPPPHHF------TSTGAGPPPALFQQQAPPQLTRYTPATATTAATFVPPQQQQVVYN-----PQ 753

Human   235 GWEQAMTQDGEIYYINHKNKTTSWLD--PRLDPRFGKAMNQRISQSAPVKQ---PPPLAPQSPQG 294
            ..:.:..:.      :.:.||.|.:.  .....:......|..|.:|.|:|   |||...|..|
  Fly   754 QQQHSSLRR------SSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAAAVQQQLLPPPGTYQYQQ- 811

Human   295 GVMGGS---------NSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQAMRNINPSTANSPKCQ 350
              :||:         ...||||.:.|||.:..:..:.:.|:..:|.:.|..:....:|...|...
  Fly   812 --VGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQHQQQQRATLVQPGFL 874

Human   351 ELALRSQLPTLEQDGGT---QNP-VSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMS 411
             .:.||..|..:|....   |.| |:....:.:..|.:..:..|  .||..|:..:....|.:.:
  Fly   875 -FSYRSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQP--PSGPPHAGGQQITPGANSA 936

Human   412 SYSV 415
            :.|:
  Fly   937 NLSI 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YAP1	XP_005271435.1	WW	174..203	CDD:238122	5/31 (16%)
YAP1	XP_005271435.1	WW	232..261	CDD:366073	4/30 (13%)
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	8/48 (17%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900