Protein Alignment YAP1 and Ufd4

DIOPT Version :9

• Sequence 1: XP_005271435.1
• Gene: YAP1 / 10413
• HGNCID: 16262
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 101/550 - (18%)
• Similarity: 175/550 - (31%)
• Gaps: 154/550 - (28%)

Human    38 PAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPK 102
            |:.|....|.|.|...||.::   |..:.....:|.:..:.:||........::|.:    .|..
  Fly  1713 PSVTLKPAQQPNAVLSIVDIK---EQPISNENVSVPSQMSISVPNLTTTSASEVPST----SEVA 1770

Human   103 SHSRQASTDAGTAGALTPQHVRAHSSP-ASLQLGAVSPGTLTPTGVVSGPAAT------------ 154
            :|:....|.|..|...|.|......:. .:.:......|....:|...|.:.|
  Fly  1771 THTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFH 1835

Human   155 ----PTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAP 215
                .|||.....|....:::   |....:.||:||: ..:.|:.|.|           |::|:.
  Fly  1836 SGLLSTAQSYPSLSSNNSENI---APSNPSNTSAGQQ-SASTINHTLT-----------MSLTST 1885

Human   216 TSPPVQ---QNMMNSASGP-----LPDGWEQAMTQDGE------------------------IYY 248
            :|...|   ::.:.|...|     |.|  |..|.:|.:                        :.:
  Fly  1886 SSDSEQVSLEDFLESCRAPALLGDLDD--EDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTF 1948

Human   249 INHK---------NKTTSWLDPRLDPRFGKAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQ 304
            ::.:         .|..||     |..|  .:.::.|...|...|.|           |.:|.||
  Fly  1949 MDDEAMENRLVGVTKRKSW-----DDEF--VLKRQFSALIPAFDPRP-----------GRTNVNQ 1995

Human   305 QQQMRLQQLQMEKERLRLKQQELLRQVRPQAMRNINPSTANSPKCQELALRSQ----LPTLEQDG 365
            ...:.:..|..|               .|:..::..|.|...| ...|.||..    :|.:|.|.
  Fly  1996 TSDLEISPLGAE---------------LPKPQQSGGPETIEQP-LLGLKLRGPGIGGIPEVEIDL 2044

Human   366 GTQNPVSSPGMSQELRTMTTNSSDPFLN------SGTYHSRDESTDSGLSMSSYSVPRTPD---- 420
            ...:......:.:.|:....|..|.|..      :..|............:.|...|:|||
  Fly  2045 SNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSK 2109

Human   421 ---DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTN-VDLGTLEGD----GMNIEGEELM 477
               ..|:....|..|..:..:.|.|    ..|.||.:...| ::...::.|    |:::..|:|.
  Fly  2110 SGASTLSPNSPMHIGFNVADNNLCS----VDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLF 2170

Human   478 PSLQEALSSDILNDMES------VLAATKL 501
                  :|..|.|.::.      |||:..|
  Fly  2171 ------ISKKITNKLQQQIQDPLVLASNAL 2194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YAP1	XP_005271435.1	WW	174..203	CDD:238122	8/28 (29%)
		WW	232..261	CDD:366073	8/61 (13%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	4/11 (36%)
		HECTc	2265..2725	CDD:238033

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900