DRSC/TRiP Functional Genomics Resources

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Protein Alignment YAP1 and HERC2

DIOPT Version :9

Sequence 1:XP_005271435.1 Gene:YAP1 / 10413 HGNCID:16262 Length:510 Species:Homo sapiens
Sequence 2:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster


Alignment Length:568 Identity:110/568 - (19%)
Similarity:178/568 - (31%) Gaps:191/568 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    45 PQAPPAGHQI--------VHVRGD------SETDLEALFNAVMNPKTANVPQTVPMRLRKLP--- 92
            |:.|...||:        :|..||      :|.....|..|..:...|.....:..||..||   
  Fly  2140 PRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHTLPSWN 2204

Human    93 ---DSFFKPP--------EPKSHSRQASTD----AGTAGA-----LTPQ------HVRAHSSPAS 131
               :||....        ..:|||....::    .|..||     |.|:      |..:|     
  Fly  2205 PVINSFLAQKLCVAAELLAEQSHSTALDSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSH----- 2264

Human   132 LQLGAVSPG---TLTPTGVVSG--------PAATPTAQHLRQSSFEIPDDVPLPAGW-------- 177
            :.:.:.:|.   .|.|.||.||        ||..|...|...|...:|.:..|...|        
  Fly  2265 MVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPA 2329

Human   178 ----EMAKTSSGQRYFLNHID-QTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPL----- 232
                |:..::.|:      :| .....|..:.|:|....|.......:::.:...|.|.:     
  Fly  2330 PELRELPSSADGR------LDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPD 2388

Human   233 -PDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFGKAMNQRISQSAPVKQ------------- 283
             ||..:....|.||   .:.:..:.|..:|:|   ..:.:..|.:|::|||.             
  Fly  2389 EPDRSDAESQQPGE---QDQQLSSGSGQEPQL---LIQCILLRATQASPVKACYSYMDLATAALN 2447

Human   284 -PPPLAPQSPQ-----GGVMGGS------------------NSNQQQQMRLQQLQMEKE------ 318
             ...||.|:.|     |||....                  |..:::|...:|::.:.:      
  Fly  2448 CIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAAT 2512

Human   319 ------------------RLRLKQQELLRQVRPQAMRNINPSTANSPKCQELALRSQLPTLEQDG 365
                              .|.|||..|..::.|...:.:.....:...|..        |:|:| 
  Fly  2513 DAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWILEHPDVCAN--------TIEED- 2568

Human   366 GTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMD 430
              ..|::|...|.:....:.|.. |..||.|..|....|..|..| :.|.|..|..| .|..:..
  Fly  2569 --TLPLASSASSHDPEADSDNEC-PSSNSTTSSSTSSDTVEGQPM-AVSGPAPPVKF-ESRKDFQ 2628

Human   431 TGDTINQSTLPSQQNRFPDYLEAI--PGTNV------------DLGTL 464
            |.|.            :..|:..:  ||..|            |:||:
  Fly  2629 TADL------------YALYVRGLVRPGMTVRCCRDFEEIKQGDMGTV 2664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
YAP1XP_005271435.1 WW 174..203 CDD:238122 5/41 (12%)
WW 232..261 CDD:366073 6/34 (18%)
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585 6/43 (14%)
Cul7 2624..2699 CDD:288381 9/53 (17%)
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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