Protein Alignment YAP1 and CG42797

DIOPT Version :9

• Sequence 1: XP_005271435.1
• Gene: YAP1 / 10413
• HGNCID: 16262
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_572574.2
• Gene: CG42797 / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 881
• Identity: 161/881 - (18%)
• Similarity: 233/881 - (26%)
• Gaps: 442/881 - (50%)

Human     5 QQPPPQPAPQGQGQPPSQ-------PPQGQGPPSG-PGQP---APAATQ---------------- 42
            |...|...|...||.|.|       ...|.|...| .|.|   .|..|.
  Fly   483 QDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSS 547

Human    43 -----AAPQAPPA-GHQIVHV--------RGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPD 93
                 |.|..||| ..|:.::        :|..::|           :..::..|   ||..:|:
  Fly   548 LASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSD-----------EVVHISST---RLPSIPE 598

Human    94 SFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQ 158
                    :|.:..|:..|..|||                 ..:.||    ||.|||.:....|
  Fly   599 --------RSAAAAAAAAAAAAGA-----------------ALMEPG----TGTVSGSSGAGAA- 633

Human   159 HLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP--------------------- 202
                      .:.|||..||....|.|:.::::|..:||:||.|
  Fly   634 ----------GEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDR 688

Human   203 -------------RKAML--------SQMNVTAPTSPP--------------------------- 219
                         |.|.|        |..|.|||.:||
  Fly   689 RYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAA 753

Human   220 --------------------------VQQN-----MMNS---ASGPLPDGWEQAMTQDGEIYYIN 250
                                      .|.|     ::|:   .|..||..||..:.|.|:.::|:
  Fly   754 LAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFID 818

Human   251 HKNKTTSWLDPRLD---PRFGKAMNQRISQ----------------------------SAPVKQP 284
            |:::.||::||||.   ||..:...|...|                            ::.|...
  Fly   819 HQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGV 883

Human   285 PPLAPQSPQGGVMG-------GSNSN--------------------------------------- 303
            |||.|..|......       |.|.|
  Fly   884 PPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYN 948

Human   304 -------------------QQQQMRLQQLQMEK------------ER----------LRLKQQEL 327
                               |.|....:||: ||            ||          |.|.:||:
  Fly   949 EKVIAFLRQPNILEILRERQGQHTMSRQLR-EKINILRVEGVPALERLGHDLQLTILLSLFEQEI 1012

Human   328 -----LRQVRPQAMRNIN---PSTANSP--KCQELALRSQLPTLEQDGGTQNP------VSSPGM 376
                 :.:..||....:|   |..|..|  :..|..|||....||..|..|.|      :....:
  Fly  1013 MGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHL 1077

Human   377 SQEL--RTMTTNSSD-----------------------------------PFLNSGTYHSRDEST 404
            .::.  |.|:.|..|                                   |:.....|.:.|..|
  Fly  1078 LEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYT 1142

Human   405 DSGLSMSSYSVPRTPDDFLNS-------------VDEMDTGD--------TINQSTLPSQQNRFP 448
            .....:|:: |....|.|..|             :|...|..        .:..|.|.|..|.|.
  Fly  1143 VQVSPLSAF-VDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFH 1206

Human   449 DYLEAIP----GTNVDLG----------------TLEGDGMNI---------------------- 471
            ..|:.|.    ||.||||                .|:..|.||
  Fly  1207 QSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERG 1271

Human   472 ---EGEELMPSLQEALSSDILN-----DMESVLAAT 499
               :.|.|:....|.:.|.:::     ::|.|:|.|
  Fly  1272 VQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGT 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YAP1	XP_005271435.1	WW	174..203	CDD:238122	11/62 (18%)
		WW	232..261	CDD:366073	10/28 (36%)
CG42797	NP_572574.2	WW	638..667	CDD:278809	11/28 (39%)
		HECTc	1068..1424	CDD:238033	40/241 (17%)
		HECTc	1092..1423	CDD:214523	37/217 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900