DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YAP1 and ptr1

DIOPT Version :9

Sequence 1:	XP_005271435.1	Gene:	YAP1 / 10413	HGNCID:	16262	Length:	510	Species:	Homo sapiens
Sequence 2:	NP_594902.1	Gene:	ptr1 / 2542537	PomBaseID:	SPAC19D5.04	Length:	3227	Species:	Schizosaccharomyces pombe

Alignment Length:	254	Identity:	49/254 - (19%)
Similarity:	93/254 - (36%)	Gaps:	60/254 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   302 SNQQQQMRLQQLQME---------------KERLRLKQQELLRQVRPQAMRNINPSTANSPKCQE 351
            ||:||...:.:::.|               .|.|.....:|| .:.....|..:..|.:......
pombe  1677 SNEQQTQAVDEIRREVLTSVLKFYKSSSSFSENLEAYYCKLL-VLAELCYRLCDAQTVSQKAPNH 1740

Human   352 LALRSQ------------LPTLEQDGGTQNPVSSPGMS------------QELRTMT-----TNS 387
            |..|||            :|||      .|.:|...|:            :.|:.:|     .:.
pombe  1741 LLRRSQDQNVKTMIDLGYIPTL------TNAISEIDMNYPVSRKVVRHILKPLQLLTKEAIFLSQ 1799

Human   388 SDPFLNSGTYHSRDESTDSGLSMSSYSV-----PRTPDDFLNSVDEMDTGDTINQSTLPSQQNRF 447
            ::|...||.  ::|...|..||.||...     ...||.:.|||..:..||.:|::....:.:..
pombe  1800 TNPEALSGA--AQDSMGDQSLSSSSEESSDSDREEPPDLYRNSVLGIFQGDIVNENDENYEDSED 1862

Human   448 PDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESF 506
            ....|.:...:...|:.:......:.:::|.|..:.::.:.:.|.:.  |:::.|..||
pombe  1863 DGVYEEMEFEDDQSGSADSVVSEDDADDVMYSDNDDMNIEFMVDEQD--ASSQNDDSSF 1919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
YAP1	XP_005271435.1	WW	174..203	CDD:238122
YAP1	XP_005271435.1	WW	232..261	CDD:366073
ptr1	NP_594902.1	DUF908	96..367	CDD:283630
		DUF913	436..735	CDD:283642
		HARE-HTH	<1930..2018	CDD:294801
		DUF4414	2267..2347	CDD:291075
		HUL4	2314..3227	CDD:227354
		HECTc	2870..3225	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900