DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YAP1 and Yap1

DIOPT Version :9

Sequence 1:	XP_005271435.1	Gene:	YAP1 / 10413	HGNCID:	16262	Length:	510	Species:	Homo sapiens
Sequence 2:	XP_006509915.1	Gene:	Yap1 / 22601	MGIID:	103262	Length:	494	Species:	Mus musculus

Alignment Length:	510	Identity:	453/510 - (88%)
Similarity:	473/510 - (92%)	Gaps:	16/510 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDL 65
            |:|.||||||||           |||..|||    .:||.|.|||.|||||||:|||||||||||
Mouse     1 MEPAQQPPPQPA-----------PQGPAPPS----VSPAGTPAAPPAPPAGHQVVHVRGDSETDL 50

Human    66 EALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPA 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    51 EALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPA 115

Human   131 SLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
            |||||||||||||.:||||||||.|.||||||||||||||||||||||||||||||||||||.||
Mouse   116 SLQLGAVSPGTLTASGVVSGPAAAPAAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHNDQ 180

Human   196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLD 260
            ||||||||||||||:||.||.||.|.|.:|||||||||||||||||||||:||||||||||||||
Mouse   181 TTTWQDPRKAMLSQLNVPAPASPAVPQTLMNSASGPLPDGWEQAMTQDGEVYYINHKNKTTSWLD 245

Human   261 PRLDPRFGKAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQ 325
            |||||||||||||||:||||||||||||||||||||:||.:||||||::||||||||||||||||
Mouse   246 PRLDPRFGKAMNQRITQSAPVKQPPPLAPQSPQGGVLGGGSSNQQQQIQLQQLQMEKERLRLKQQ 310

Human   326 ELLRQVRPQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDP 390
            ||.|||||||:|||||||||:|||||||||||||||||||||.|.||||||||||||||||||||
Mouse   311 ELFRQVRPQAIRNINPSTANAPKCQELALRSQLPTLEQDGGTPNAVSSPGMSQELRTMTTNSSDP 375

Human   391 FLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIP 455
            ||||||||||||||||||||||||:||||||||||||||||||||:||||||||:||||||||:|
Mouse   376 FLNSGTYHSRDESTDSGLSMSSYSIPRTPDDFLNSVDEMDTGDTISQSTLPSQQSRFPDYLEALP 440

Human   456 GTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL 510
            ||||||||||||.||||||||||||||||||:|| |:||||||||||||||||||
Mouse   441 GTNVDLGTLEGDAMNIEGEELMPSLQEALSSEIL-DVESVLAATKLDKESFLTWL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YAP1	XP_005271435.1	WW	174..203	CDD:238122	27/28 (96%)
YAP1	XP_005271435.1	WW	232..261	CDD:366073	27/28 (96%)
Yap1	XP_006509915.1	FAM181	<61..>141	CDD:373671	76/79 (96%)
		WW	159..188	CDD:238122	27/28 (96%)
		WW	217..246	CDD:366073	27/28 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83969581
Domainoid	1	1.000	448	1.000	Domainoid score	I9617
eggNOG	1	0.900	-	-		E1_COG5021
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4452
Inparanoid	1	1.050	896	1.000	Inparanoid score	I6850
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51295
OrthoDB	1	1.010	-	-		D1006566at2759
OrthoFinder	1	1.000	-	-		FOG0003509
OrthoInspector	1	1.000	-	-		oto121851
orthoMCL	1	0.900	-	-		OOG6_107951
Panther	1	1.100	-	-	LDO	PTHR17616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4834
SonicParanoid	1	1.000	-	-		X2881
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300