Protein Alignment YAP1 and yap-1

DIOPT Version :10

• Sequence 1: XP_005271435.1
• Gene: YAP1 / 10413
• HGNCID: 16262
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_001369894.1
• Gene: yap-1 / 181267
• WormBaseID: WBGene00008748
• Length: 442
• Species: Caenorhabditis elegans
• Alignment Length: 516
• Identity: 112/516 - (21%)
• Similarity: 165/516 - (31%)
• Gaps: 176/516 - (34%)

Human     2 DPGQQPPPQPAPQGQGQPPSQP------PQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD 60
            :..|.....|.|.........|      |.|....|.....:||....:.|||      :|.|..
 Worm    45 EKNQNQKKNPLPSSYYHQKRNPGSSAHSPYGSVDESSRTAVSPAMDMVSNQAP------IHTRQV 103

Human    61 SETDLEALFN------AVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAG-AL 118
            |..:|....|      .|.:|...||..                    .||:..|....|.| :.
 Worm   104 SAPNLHTSVNNGQSSATVPHPSHHNVHH--------------------QHSKSVSALPMTIGYSP 148

Human   119 TPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSS---------FEIPDDV--- 171
            .|.||::.|..|:...          .|:...|......|..|:.|         |..|.||
 Worm   149 VPSHVKSVSHEANYSY----------AGLSEIPQQQGMMQQNREKSLSLDPMRRPFMTPQDVEQL 203

Human   172 PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTA-PTSPPVQQNMMNSASGPLPDG 235
            |:|.||||...|.|.|||.:|..:||||.|||   |.|...|. .....:.||..|:.
 Worm   204 PMPQGWEMCYDSDGVRYFKDHNSKTTTWDDPR---LKQQEQTGFGLGENIGQNRYNNC------- 258

Human   236 WEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFGKAMNQRISQSAP-VKQPPPLAPQSPQGGVMGG 299
                       |...|.                       |:|.| :.|...:.|..||     .
 Worm   259 -----------YDNGHS-----------------------SRSLPSIHQHQQMIPNHPQ-----P 284

Human   300 SNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQAMRNINPSTANSPKCQELALRSQLPTLEQD 364
            ..|:|||...:||||.|:..::.|..:|           ||....:||:....|:
 Worm   285 QYSSQQQMDYIQQLQNERMMIQEKNAQL-----------INSGLVDSPQPPYQAI---------- 328

Human   365 GGTQNPVSSPGMSQELRTMTTNSSDP-FLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDE 428
                :|:||..|         :|.|| |:    |..:.::.:|....:.:::.:.|:.:.||...
 Worm   329 ----SPMSSTMM---------HSHDPNFM----YQQQQQAQNSQQQQTPHTLHQIPNQYQNSQMN 376

Human   429 MDTGDTINQSTL-----------PSQQNRFP--------------DYLEAIPGTNVDLGTL 464
            .|:...::.|.:           |...|..|              .||:.....|..:|::
 Worm   377 DDSAMEVDYSMVSHPQQLQHQHQPHMHNNMPSNYVIDDINPHEFDQYLQISNDNNRGVGSM 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YAP1	XP_005271435.1	WW	174..203	CDD:238122	16/28 (57%)
		WW	231..263	CDD:197736	2/31 (6%)
yap-1	NP_001369894.1	WW	206..236	CDD:238122	18/32 (56%)