DRSC/TRiP Functional Genomics Resources

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Protein Alignment RAPGEF3 and Sos

DIOPT Version :10

Sequence 1:XP_011536054.1 Gene:RAPGEF3 / 10411 HGNCID:16629 Length:938 Species:Homo sapiens
Sequence 2:NP_476597.2 Gene:Sos / 34790 FlyBaseID:FBgn0001965 Length:1596 Species:Drosophila melanogaster


Alignment Length:649 Identity:132/649 - (20%)
Similarity:234/649 - (36%) Gaps:204/649 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   334 APR-AATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEH-GKVVLVLERASQGAGPSRPPTP 396
            ||| ...|:|...|..    .|.|:...:..|..|:| |:.| ..::..:||..    |.|.|:|
  Fly   559 APRMQPPIVLTAKNAQ----HKHDWMADLLMVITKSM-LDRHLDSILQDIERKH----PLRMPSP 614

Human   397 GRNRYTVMSGTPEKILE----------------LLLEAMGPDSSAH---DPTETFLSDFLLTHRV 442
            ...::.|.......:||                .|:|.:    :.|   ||  ||:..||.|:|.
  Fly   615 EIYKFAVPDSGDNIVLEERESAGVPMIKGATLCKLIERL----TYHIYADP--TFVRTFLTTYRY 673

Human   443 FMPSAQLCAALLHHFHV-EP-----------AGG------------SEQE-----RSTYVCNKRQ 478
            |....||...|:..|:: :|           |||            |.:|     |..||...:.
  Fly   674 FCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQF 738

Human   479 QILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNAS 543
            ::|.::..||..:......||:   .|:||.:.                       ||:      
  Fly   739 RVLNVLRHWVDHHFYDFEKDPM---LLEKLLNF-----------------------LEH------ 771

Human   544 PQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQED 608
              :..:::..|:.                                       ||.:::....:::
  Fly   772 --VNGKSMRKWVD---------------------------------------SVLKIVQRKNEQE 795

Human   609 GWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGL 673
            ...|..|.        |.|..|..        :...|.|.| .|:..|..||             
  Fly   796 KSNKKIVY--------AYGHDPPP--------IEHHLSVPN-DEITLLTLHP------------- 830

Human   674 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRD--VTTANLERFMRRFNELQYWVATE 736
                 .:||.|||..::.::.::...||:.   .|...:|  |.:.||.:.|:....:..|:...
  Fly   831 -----LELARQLTLLEFEMYKNVKPSELVG---SPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKS 887

Human   737 LCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSA 801
            :........|..::::.|::...:.|..|.|...:::..:..:::.||..|::.||.:.||.   
  Fly   888 ITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKF--- 949

Human   802 LERLLDPSWNH-RVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVEN--LINFEKMRMMARA 863
            ||...:.|.:| :.|:..|..::||.:||....|.::..:.|||..|:.|  ||||.|.|   :.
  Fly   950 LEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKRR---KV 1011

Human   864 ARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQ-----SLSTRSPASTWAYVQQLKV 922
            |.::...:.:...|..        |:|:|.:.:.   .||     .||.:. .|.:.|.:.|::
  Fly  1012 AEIIGEIQQYQNQPYC--------LNEESTIRQF---FEQLDPFNGLSDKQ-MSDYLYNESLRI 1063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RAPGEF3XP_011536054.1 DEP_Epac 100..238 CDD:239884
CAP_ED 262..371 CDD:237999 11/37 (30%)
REM 407..526 CDD:100121 35/166 (21%)
RasGEF 673..905 CDD:238087 55/241 (23%)
SosNP_476597.2 HFD_SOS1_rpt1 68..145 CDD:467039
HFD_SOS1_rpt2 153..227 CDD:467040
RhoGEF 249..432 CDD:238091
PH_SOS 476..586 CDD:269963 8/30 (27%)
RasGEFN 637..791 CDD:214571 38/232 (16%)
RasGEF 825..1062 CDD:238087 62/275 (23%)
PHA03247 <1197..1502 CDD:223021
Blue background indicates that the domain is not in the aligned region.

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