DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDS1 and Cds

DIOPT Version :9

Sequence 1:	NP_001254.2	Gene:	CDS1 / 1040	HGNCID:	1800	Length:	461	Species:	Homo sapiens
Sequence 2:	NP_001286976.1	Gene:	Cds / 43950	FlyBaseID:	FBgn0010350	Length:	447	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	260/461 - (56%)
Similarity:	324/461 - (70%)	Gaps:	31/461 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLELRHRGSCPGPREAVSPPHREGEAAGGD--HETESTSDKETDIDDRYGDLDSRTDSDIPE--- 60
            |.|:|.       |:....|..:...:|.|  ::..|.:|....:|..        :..|||
  Fly     1 MAEVRR-------RKGEDEPLEDTAISGSDAANKRNSAADSSDHVDSE--------EEKIPEEKF 50

Human    61 -------IPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFLIIYMGSFMLMLLVLGI 118
                   :|..:|:|||||..||..|..|||||.||||.|..||..|.||||.|...||:..|.:
  Fly    51 VDELAKNLPQGTDKTPEILDSALKDLPDRWKNWVIRGIFTWIMICGFALIIYGGPLALMITTLLV 115

Human   119 QVKCFHEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLIRYH 183
            |||||.|||:|||:||..:.|||||:|||||||..|||||||.:.|||...:.|.|.|:||:.||
  Fly   116 QVKCFQEIISIGYQVYRIHGLPWFRSLSWYFLLTSNYFFYGENLVDYFGVVINRVEYLKFLVTYH 180

Human   184 RFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMIWFLVPISS 248
            ||:|||||:.||..||||||||:|..||.:||||||:|||.||||:|:|||:|||:|||:||:|.
  Fly   181 RFLSFALYIIGFVWFVLSLVKKYYIKQFSLFAWTHVSLLIVVTQSYLIIQNIFEGLIWFIVPVSM 245

Human   249 VICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVVFGFIAAYVLSKYQYFVCPVEYRSD 313
            ::|||:.||:|||||||||||||||||||||||||.|:||:||.:.:|||..||||:||::|..:
  Fly   246 IVCNDVMAYVFGFFFGRTPLIKLSPKKTWEGFIGGGFATVLFGILFSYVLCNYQYFICPIQYSEE 310

Human   314 VNSFVTECEPSELFQLQTYSLPPFLKAVLRQERVSLYPFQIHSIALSTFASLIGPFGGFFASGFK 378
            .......|.||.||..|.|||..|...    :.::||||..|||:||.|:|:|||||||||||||
  Fly   311 QGRMTMSCVPSYLFTPQEYSLKLFGIG----KTLNLYPFIWHSISLSLFSSIIGPFGGFFASGFK 371

Human   379 RAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYK 443
            ||||||||.:.||||||||||||||:||||||:|||:||||.|:|:|:|.|:..|:|:||..||:
  Fly   372 RAFKIKDFGDMIPGHGGIMDRFDCQFLMATFVNVYISSFIRTPSPAKLLTQIYNLKPDQQYQIYQ 436

Human   444 TLKTHL 449
            :||.:|
  Fly   437 SLKDNL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDS1	NP_001254.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		14/77 (18%)
CDS1	NP_001254.2	CTP_transf_1	123..457	CDD:304393	212/327 (65%)
Cds	NP_001286976.1	CTP_transf_1	120..438	CDD:304393	209/321 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155355
Domainoid	1	1.000	462	1.000	Domainoid score	I482
eggNOG	1	0.900	-	-		E1_COG0575
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68173
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1216
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54574
OrthoDB	1	1.010	-	-		D1072976at2759
OrthoFinder	1	1.000	-	-		FOG0001281
OrthoInspector	1	1.000	-	-		otm41620
orthoMCL	1	0.900	-	-		OOG6_101561
Panther	1	1.100	-	-	LDO	PTHR13773
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2065
SonicParanoid	1	1.000	-	-		X636
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800